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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36739

FusionGeneSummary for SULF2_BCAS1

check button Fusion gene summary
Fusion gene informationFusion gene name: SULF2_BCAS1
Fusion gene ID: 36739
HgeneTgene
Gene symbol

SULF2

BCAS1

Gene ID

55959

8537

Gene namesulfatase 2breast carcinoma amplified sequence 1
SynonymsHSULF-2AIBC1|NABC1
Cytomap

20q13.12

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionextracellular sulfatase Sulf-2breast carcinoma-amplified sequence 1amplified and overexpressed in breast cancernovel amplified in breast cancer 1
Modification date2018051920180519
UniProtAcc

Q8IWU5

O75363

Ensembl transtripts involved in fusion geneENST00000359930, ENST00000484875, 
ENST00000361612, ENST00000467815, 
ENST00000478766, 
ENST00000371440, 
ENST00000371435, ENST00000395961, 
ENST00000434986, ENST00000411563, 
Fusion gene scores* DoF score6 X 4 X 4=9611 X 7 X 8=616
# samples 611
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULF2 [Title/Abstract] AND BCAS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULF2

GO:0030177

positive regulation of Wnt signaling pathway

19520866

HgeneSULF2

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-CC-A8HS-01ASULF2chr20

46305238

-BCAS1chr20

52645511

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000359930ENST00000371440SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000359930ENST00000371435SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000359930ENST00000395961SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-intronENST00000359930ENST00000434986SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-5UTRENST00000359930ENST00000411563SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000484875ENST00000371440SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000484875ENST00000371435SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000484875ENST00000395961SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-intronENST00000484875ENST00000434986SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-5UTRENST00000484875ENST00000411563SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000361612ENST00000371440SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000361612ENST00000371435SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000361612ENST00000395961SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-intronENST00000361612ENST00000434986SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-5UTRENST00000361612ENST00000411563SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000467815ENST00000371440SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000467815ENST00000371435SULF2chr20

46305238

-BCAS1chr20

52645511

-
Frame-shitENST00000467815ENST00000395961SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-intronENST00000467815ENST00000434986SULF2chr20

46305238

-BCAS1chr20

52645511

-
5CDS-5UTRENST00000467815ENST00000411563SULF2chr20

46305238

-BCAS1chr20

52645511

-
intron-3CDSENST00000478766ENST00000371440SULF2chr20

46305238

-BCAS1chr20

52645511

-
intron-3CDSENST00000478766ENST00000371435SULF2chr20

46305238

-BCAS1chr20

52645511

-
intron-3CDSENST00000478766ENST00000395961SULF2chr20

46305238

-BCAS1chr20

52645511

-
intron-intronENST00000478766ENST00000434986SULF2chr20

46305238

-BCAS1chr20

52645511

-
intron-5UTRENST00000478766ENST00000411563SULF2chr20

46305238

-BCAS1chr20

52645511

-

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FusionProtFeatures for SULF2_BCAS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SULF2

Q8IWU5

BCAS1

O75363

Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SULF2_BCAS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SULF2_BCAS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SULF2MYC, PTCH1, CASQ2, NAAA, PON2, CSGALNACT2, APP, LRRC4C, DEFA1, GPR156, OS9, KBTBD7, SDC2, DKK3, DEFA5, TRPC4AP, GNSBCAS1DYNLL1, RUVBL2, BCAS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SULF2_BCAS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SULF2_BCAS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSULF2C0014175Endometriosis2CTD_human
TgeneBCAS1C0033578Prostatic Neoplasms1CTD_human