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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36736

FusionGeneSummary for SULF1_PLSCR1

check button Fusion gene summary
Fusion gene informationFusion gene name: SULF1_PLSCR1
Fusion gene ID: 36736
HgeneTgene
Gene symbol

SULF1

PLSCR1

Gene ID

23213

5359

Gene namesulfatase 1phospholipid scramblase 1
SynonymsSULF-1MMTRA1B
Cytomap

8q13.2-q13.3

3q24

Type of geneprotein-codingprotein-coding
Descriptionextracellular sulfatase Sulf-1sulfatase FPphospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase
Modification date2018051920180523
UniProtAcc

Q8IWU6

O15162

Ensembl transtripts involved in fusion geneENST00000260128, ENST00000458141, 
ENST00000402687, ENST00000419716, 
ENST00000521946, 		ENST00000342435, 
ENST00000448205, ENST00000487389, 
ENST00000448787, ENST00000484560, 
Fusion gene scores* DoF score5 X 5 X 5=1255 X 5 X 1=25
# samples 55
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SULF1 [Title/Abstract] AND PLSCR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULF1

GO:0001937

negative regulation of endothelial cell proliferation

16778174

HgeneSULF1

GO:0016525

negative regulation of angiogenesis

16778174

HgeneSULF1

GO:0030177

positive regulation of Wnt signaling pathway

19520866

HgeneSULF1

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675|19666466|19822709

HgeneSULF1

GO:0048010

vascular endothelial growth factor receptor signaling pathway

16778174

TgenePLSCR1

GO:0006915

apoptotic process

10770950

TgenePLSCR1

GO:0017121

phospholipid scrambling

9218461|10770950|18629440

TgenePLSCR1

GO:0045944

positive regulation of transcription by RNA polymerase II

16091359

TgenePLSCR1

GO:2000373

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

17567603


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW934802SULF1chr8

70483724

+PLSCR1chr3

146248391

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000260128ENST00000342435SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000260128ENST00000448205SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000260128ENST00000487389SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000260128ENST00000448787SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000260128ENST00000484560SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000458141ENST00000342435SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000458141ENST00000448205SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000458141ENST00000487389SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000458141ENST00000448787SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000458141ENST00000484560SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000402687ENST00000342435SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000402687ENST00000448205SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000402687ENST00000487389SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000402687ENST00000448787SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000402687ENST00000484560SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000419716ENST00000342435SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000419716ENST00000448205SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000419716ENST00000487389SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000419716ENST00000448787SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000419716ENST00000484560SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000521946ENST00000342435SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000521946ENST00000448205SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000521946ENST00000487389SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000521946ENST00000448787SULF1chr8

70483724

+PLSCR1chr3

146248391

-
intron-intronENST00000521946ENST00000484560SULF1chr8

70483724

+PLSCR1chr3

146248391

-

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FusionProtFeatures for SULF1_PLSCR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SULF1

Q8IWU6

PLSCR1

O15162

Exhibits arylsulfatase activity and highly specificendoglucosamine-6-sulfatase activity. It can remove sulfate fromthe C-6 position of glucosamine within specific subregions ofintact heparin. Diminishes HSPG (heparan sulfate proteoglycans)sulfation, inhibits signaling by heparin-dependent growth factors,diminishes proliferation, and facilitates apoptosis in response toexogenous stimulation. May mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ionsthat results in a loss of phospholipid asymmetry in the plasmamembrane. May play a central role in the initiation of fibrin clotformation, in the activation of mast cells and in the recognitionof apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon(IFN) by amplifying and enhancing the IFN response throughincreased expression of select subset of potent antiviral genes.May contribute to cytokine-regulated cell proliferation anddifferentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SULF1_PLSCR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SULF1_PLSCR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SULF1_PLSCR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SULF1_PLSCR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSULF1C0919267ovarian neoplasm1CTD_human
TgenePLSCR1C0021400Influenza1CTD_human
TgenePLSCR1C0023893Liver Cirrhosis, Experimental1CTD_human