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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3673

FusionGeneSummary for AZGP1_CAPRIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: AZGP1_CAPRIN2
Fusion gene ID: 3673
HgeneTgene
Gene symbol

AZGP1

CAPRIN2

Gene ID

563

65981

Gene namealpha-2-glycoprotein 1, zinc-bindingcaprin family member 2
SynonymsZA2G|ZAGC1QDC1|EEG-1|EEG1|RNG140
Cytomap

7q22.1

12p11.21

Type of geneprotein-codingprotein-coding
Descriptionzinc-alpha-2-glycoproteinAlpha-2-glycoprotein, zincZn-alpha2-glycoproteintesticular tissue protein Li 227zn-alpha-2-GPzn-alpha-2-glycoproteincaprin-2C1q domain-containing protein 1RNA granule protein 140cytoplasmic activation/proliferation-associated protein 2gastric cancer multidrug resistance-associated protein
Modification date2018052720180519
UniProtAcc

P25311

Q6IMN6

Ensembl transtripts involved in fusion geneENST00000483612, ENST00000292401, 
ENST00000411734, 
ENST00000298892, 
ENST00000395805, ENST00000251071, 
ENST00000308433, ENST00000417045, 
ENST00000538387, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 8 X 3=72
# samples 117
** MAII scorelog2(11/50*10)=1.13750352374994
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AZGP1 [Title/Abstract] AND CAPRIN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAZGP1

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

24248522

HgeneAZGP1

GO:0007155

cell adhesion

9813179

TgeneCAPRIN2

GO:0030308

negative regulation of cell growth

14593112

TgeneCAPRIN2

GO:0032092

positive regulation of protein binding

18762581

TgeneCAPRIN2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18762581

TgeneCAPRIN2

GO:0045944

positive regulation of transcription by RNA polymerase II

18762581

TgeneCAPRIN2

GO:0090263

positive regulation of canonical Wnt signaling pathway

18762581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AX795406AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
ChiTaRS3.1AX795404AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
ChiTaRS3.1AX795402AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
ChiTaRS3.1AX795408AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
ChiTaRS3.1AX795410AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863267

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3UTRENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863309

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3UTRENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863313

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573583

-CAPRIN2chr12

30863246

-
intron-3CDSENST00000483612ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000483612ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000483612ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000483612ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3CDSENST00000292401ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000292401ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000292401ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000292401ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3CDSENST00000411734ENST00000298892AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000395805AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000251071AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-3UTRENST00000411734ENST00000308433AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000411734ENST00000417045AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-
intron-intronENST00000411734ENST00000538387AZGP1chr7

99573584

-CAPRIN2chr12

30863228

-

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FusionProtFeatures for AZGP1_CAPRIN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AZGP1

P25311

CAPRIN2

Q6IMN6

Stimulates lipid degradation in adipocytes and causesthe extensive fat losses associated with some advanced cancers.May bind polyunsaturated fatty acids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AZGP1_CAPRIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AZGP1_CAPRIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AZGP1_CAPRIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AZGP1_CAPRIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAZGP1C0001418Adenocarcinoma1CTD_human
HgeneAZGP1C0024121Lung Neoplasms1CTD_human
HgeneAZGP1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneAZGP1C0033578Prostatic Neoplasms1CTD_human
HgeneAZGP1C0037199Sinusitis1CTD_human