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Fusion gene ID: 36720 |
FusionGeneSummary for SUFU_ADK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SUFU_ADK | Fusion gene ID: 36720 | Hgene | Tgene | Gene symbol | SUFU | ADK | Gene ID | 51684 | 132 |
| Gene name | SUFU negative regulator of hedgehog signaling | adenosine kinase | |
| Synonyms | JBTS32|PRO1280|SUFUH|SUFUXL | AK | |
| Cytomap | 10q24.32 | 10q22.2|10q11-q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | suppressor of fused homolog | adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UMX1 | P55263 | |
| Ensembl transtripts involved in fusion gene | ENST00000369902, ENST00000369899, ENST00000423559, ENST00000471000, | ENST00000539909, ENST00000286621, ENST00000372734, ENST00000541550, ENST00000467840, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 18 X 8 X 11=1584 |
| # samples | 8 | 21 | |
| ** MAII score | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/1584*10)=-2.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SUFU [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SUFU | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10564661 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-4P-AA8J-01A | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369902 | ENST00000539909 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369902 | ENST00000286621 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369902 | ENST00000372734 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369902 | ENST00000541550 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| 5CDS-intron | ENST00000369902 | ENST00000467840 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| In-frame | ENST00000369899 | ENST00000539909 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369899 | ENST00000286621 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369899 | ENST00000372734 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000369899 | ENST00000541550 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| 5CDS-intron | ENST00000369899 | ENST00000467840 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| In-frame | ENST00000423559 | ENST00000539909 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000423559 | ENST00000286621 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000423559 | ENST00000372734 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| Frame-shift | ENST00000423559 | ENST00000541550 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| 5CDS-intron | ENST00000423559 | ENST00000467840 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| intron-3CDS | ENST00000471000 | ENST00000539909 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| intron-3CDS | ENST00000471000 | ENST00000286621 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| intron-3CDS | ENST00000471000 | ENST00000372734 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| intron-3CDS | ENST00000471000 | ENST00000541550 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
| intron-intron | ENST00000471000 | ENST00000467840 | SUFU | chr10 | 104309863 | + | ADK | chr10 | 76468079 | + |
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FusionProtFeatures for SUFU_ADK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SUFU | ADK |
| Negative regulator in the hedgehog/smoothened signalingpathway. Down-regulates GLI1-mediated transactivation of targetgenes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes(PubMed:24311597, PubMed:24217340). Part of a corepressor complexthat acts on DNA-bound GLI1. May also act by linking GLI1 to BTRCand thereby targeting GLI1 to degradation by the proteasome.Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect isovercome by binding of STK36 to both SUFU and a GLI protein(PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressorform (GLI3R) or the activator form (GLI3A) of the full-length formof GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasmand is maintained in a neutral state. Without the Hh signal, theSUFU-GLI3 complex is recruited to cilia, leading to the efficientprocessing of GLI3FL into GLI3R. When Hh signaling is initiated,SUFU dissociates from GLI3FL and the latter translocates to thenucleus, where it is phosphorylated, destabilized, and convertedto a transcriptional activator (GLI3A). Required for normalembryonic development. Required for the proper formation of hairfollicles and the control of epidermal differentiation (Bysimilarity). {ECO:0000250|UniProtKB:Q9Z0P7,ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:10564661,ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:12068298,ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:15367681,ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:24217340,ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28965847}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SUFU | chr10:104309863 | chr10:76468079 | ENST00000369899 | + | 3 | 11 | 279_360 | 151 | 434 | Region | Intrinsically disordered |
| Hgene | >SUFU | chr10:104309863 | chr10:76468079 | ENST00000369902 | + | 3 | 12 | 279_360 | 151 | 485 | Region | Intrinsically disordered |
| Hgene | >SUFU | chr10:104309863 | chr10:76468079 | ENST00000423559 | + | 3 | 10 | 279_360 | 151 | 482 | Region | Intrinsically disordered |
| Tgene | ADK | chr10:104309863 | chr10:76468079 | ENST00000286621 | + | 9 | 11 | 8_16 | 321 | 363 | Motif | Nuclear localization signal |
| Tgene | ADK | chr10:104309863 | chr10:76468079 | ENST00000372734 | + | 9 | 11 | 8_16 | 304 | 346 | Motif | Nuclear localization signal |
| Tgene | ADK | chr10:104309863 | chr10:76468079 | ENST00000539909 | + | 8 | 10 | 8_16 | 264 | 306 | Motif | Nuclear localization signal |
| Tgene | ADK | chr10:104309863 | chr10:76468079 | ENST00000541550 | + | 8 | 10 | 8_16 | 286 | 328 | Motif | Nuclear localization signal |
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FusionGeneSequence for SUFU_ADK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SUFU_ENST00000369902_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_193aa MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHY ISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSGFLSQLVSDKPLTECIRAGHYAASIIIRR >In-frame_SUFU_ENST00000369899_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_193aa MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHY ISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSGFLSQLVSDKPLTECIRAGHYAASIIIRR >In-frame_SUFU_ENST00000423559_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_193aa MAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNVGSPSANIPEHWHY ISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSGFLSQLVSDKPLTECIRAGHYAASIIIRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SUFU_ENST00000369902_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_579nt ATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTT CCCCCGGGACTGCACGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTAC TGGTTGGGTGGCCCAGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTAC ATCAGCTTCGGCCTGAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTG ACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAG TCAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGG >In-frame_SUFU_ENST00000369899_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_579nt ATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTT CCCCCGGGACTGCACGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTAC TGGTTGGGTGGCCCAGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTAC ATCAGCTTCGGCCTGAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTG ACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAG TCAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGG >In-frame_SUFU_ENST00000423559_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_579nt ATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTT CCCCCGGGACTGCACGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTAC TGGTTGGGTGGCCCAGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTAC ATCAGCTTCGGCCTGAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTG ACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAG TCAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SUFU_ENST00000369902_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_999nt GACAGCCTGGGCGGACAGTGCGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGT CCGCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCG GCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCA CGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCC AGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCT GAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAA GAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGGTTTTCTGTC TCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTT TCCTGAGAAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCC ATATTAATAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCT TGTAGAATCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATA >In-frame_SUFU_ENST00000369899_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_979nt CGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGTCCGCCCGCTGGCCCGTCAGT GCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCC CCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAGTGCC GCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAGACCCCTTGGACTATGTTA GCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGTGACA ACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTG CCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGGTTTTCTGTCTCAACTGGTCTCTGACAAGC CTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCC ACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAAAGAAGAAAAT TATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCTTTATTATCTC >In-frame_SUFU_ENST00000423559_chr10_104309863_+_ADK_ENST00000539909_chr10_76468079_+_907nt GCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGC CTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACG CCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAG ACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGA GTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGA GAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGGTTTTCTGTCTC AACTGGTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTC CTGAGAAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCAT ATTAATAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTG TAGAATCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATA |
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FusionGenePPI for SUFU_ADK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SUFU | QPRT, GLIS3, RCN3, ZNF446, ZNF764, MID1IP1, ZNF263, PEX26, GLI1, SUFU, GLI2, GLI3, ZNF747, HDX, SAP18, FBXL17, NXPH3, NFATC3, LIPT1, NR2E1, TTLL3, FAM90A1, ALDH1B1, ZBTB46, LDLRAD4, EDEM1, STK36, CDC25C, BFSP2, ZNF785, ZFC3H1, UBE3D, LRRC36, LOXL3, OVOL1, PEX11A, PRPF31, PCK2, BMP4 | ADK | FICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUFU_ADK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ADK | P55263 | DB00811 | Ribavirin | Adenosine kinase | small molecule | approved |
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RelatedDiseases for SUFU_ADK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SUFU | C0007117 | Basal cell carcinoma | 1 | CTD_human;HPO |
| Tgene | ADK | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | ADK | C0242184 | Hypoxia | 1 | CTD_human |
| Tgene | ADK | C3280381 | HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | ADK | C3714756 | Intellectual Disability | 1 | CTD_human |
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