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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36697

FusionGeneSummary for STYX_MDGA2

check button Fusion gene summary
Fusion gene informationFusion gene name: STYX_MDGA2
Fusion gene ID: 36697
HgeneTgene
Gene symbol

STYX

MDGA2

Gene ID

6815

161357

Gene nameserine/threonine/tyrosine interacting proteinMAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms-MAMDC1|c14_5286
Cytomap

14q22.1

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine/tyrosine-interacting proteinprotein tyrosine phosphatase-like proteinMAM domain-containing glycosylphosphatidylinositol anchor protein 2MAM domain containing 1
Modification date2018052320180522
UniProtAcc

Q8WUJ0

Q7Z553

Ensembl transtripts involved in fusion geneENST00000442123, ENST00000354586, 
ENST00000556861, 		ENST00000426342, 
ENST00000399232, ENST00000399222, 
ENST00000357362, ENST00000439988, 
ENST00000472499, 
Fusion gene scores* DoF score4 X 3 X 4=484 X 4 X 2=32
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STYX [Title/Abstract] AND MDGA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTYX

GO:0032091

negative regulation of protein binding

28007894


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-05-4434-01ASTYXchr14

53197249

+MDGA2chr14

47770753

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000442123ENST00000426342STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000442123ENST00000399232STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-intronENST00000442123ENST00000399222STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000442123ENST00000357362STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000442123ENST00000439988STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000442123ENST00000472499STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000354586ENST00000426342STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000354586ENST00000399232STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-intronENST00000354586ENST00000399222STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000354586ENST00000357362STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000354586ENST00000439988STYXchr14

53197249

+MDGA2chr14

47770753

-
5CDS-5UTRENST00000354586ENST00000472499STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-5UTRENST00000556861ENST00000426342STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-5UTRENST00000556861ENST00000399232STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-intronENST00000556861ENST00000399222STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-5UTRENST00000556861ENST00000357362STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-5UTRENST00000556861ENST00000439988STYXchr14

53197249

+MDGA2chr14

47770753

-
intron-5UTRENST00000556861ENST00000472499STYXchr14

53197249

+MDGA2chr14

47770753

-

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FusionProtFeatures for STYX_MDGA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STYX

Q8WUJ0

MDGA2

Q7Z553

Catalytically inactive phosphatase (PubMed:23847209).Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). Modulates cell-fate decisions and cellmigration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). By binding to the F-box of FBXW7, prevents theassembly of FBXW7 into the SCF E3 ubiquitin-protein ligasecomplex, and thereby inhibits degradation of its substrates(PubMed:28007894). Plays a role in spermatogenesis (Bysimilarity). {ECO:0000250|UniProtKB:Q60969,ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. May be involved in cell-cell interactions.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STYX_MDGA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STYX_MDGA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STYXFBXL12, FAM172A, FBXL14, FBXO33, FBXO38, FBXW7, HDLBP, HSPA6, KPNA1, PAK4, SF3B4, SKP1, USP7, STYX, CAP1, TWF1, CAP2, TWF2, TLR9, FHL3, C17orf75, FAM91A1, CAPZB, CAPZA2, WDR11, ELP2, CAPZA1, CUL1, CFL1, LMTK2, AATK, ERBB4, ERBB2, EGFR, ERBB3, TEK, KIT, KDR, ROR1, ROR2, MUSK, INSRR, IGF1R, INSR, PTK7, EPHA3, EPHA7, EPHA2, EPHB6, PSPC1, ACTBL2, RRBP1, C2orf49, GTF2I, BANF1, AIMP1, COA6, PEBP1, BLVRB, FBXO31, MITD1, KRT80, RPA2, TPR, CPOX, UNG, HRNR, MAPK1MDGA2TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STYX_MDGA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STYX_MDGA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource