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Fusion gene ID: 36666 |
FusionGeneSummary for STX8_MYOCD |
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Fusion gene information | Fusion gene name: STX8_MYOCD | Fusion gene ID: 36666 | Hgene | Tgene | Gene symbol | STX8 | MYOCD | Gene ID | 9482 | 93649 |
Gene name | syntaxin 8 | myocardin | |
Synonyms | CARB | MYCD | |
Cytomap | 17p13.1 | 17p12 | |
Type of gene | protein-coding | protein-coding | |
Description | syntaxin-8CIP-1-associated regulator of cyclin B | myocardin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UNK0 | Q8IZQ8 | |
Ensembl transtripts involved in fusion gene | ENST00000306357, ENST00000574431, ENST00000573373, | ENST00000425538, ENST00000343344, ENST00000395988, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 2=12 |
# samples | 6 | 3 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STX8 [Title/Abstract] AND MYOCD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STX8 | GO:0045022 | early endosome to late endosome transport | 10564279 |
Hgene | STX8 | GO:1903076 | regulation of protein localization to plasma membrane | 18570918 |
Tgene | MYOCD | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation | 15907818 |
Tgene | MYOCD | GO:0008285 | negative regulation of cell proliferation | 18451334 |
Tgene | MYOCD | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 18451334 |
Tgene | MYOCD | GO:0045893 | positive regulation of transcription, DNA-templated | 19797053 |
Tgene | MYOCD | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14970199|17215356|19578358 |
Tgene | MYOCD | GO:0045987 | positive regulation of smooth muscle contraction | 17215356 |
Tgene | MYOCD | GO:0051091 | positive regulation of DNA binding transcription factor activity | 19098903 |
Tgene | MYOCD | GO:0051152 | positive regulation of smooth muscle cell differentiation | 18451334 |
Tgene | MYOCD | GO:2000721 | positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | 15907818 |
Tgene | MYOCD | GO:2000727 | positive regulation of cardiac muscle cell differentiation | 18451334 |
Tgene | MYOCD | GO:2001015 | negative regulation of skeletal muscle cell differentiation | 18451334 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-DK-A3IT-01A | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000306357 | ENST00000425538 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
Frame-shift | ENST00000306357 | ENST00000343344 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
5CDS-intron | ENST00000306357 | ENST00000395988 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
intron-3CDS | ENST00000574431 | ENST00000425538 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
intron-3CDS | ENST00000574431 | ENST00000343344 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
intron-intron | ENST00000574431 | ENST00000395988 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
5UTR-3CDS | ENST00000573373 | ENST00000425538 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
5UTR-3CDS | ENST00000573373 | ENST00000343344 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
5UTR-intron | ENST00000573373 | ENST00000395988 | STX8 | chr17 | 9471688 | - | MYOCD | chr17 | 12608445 | + |
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FusionProtFeatures for STX8_MYOCD |
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Hgene | Tgene |
STX8 | MYOCD |
Vesicle trafficking protein that functions in the earlysecretory pathway, possibly by mediating retrograde transport fromcis-Golgi membranes to the ER. | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single ormultiple CArG boxes DNA sequence. Acts as a cofactor of serumresponse factor (SRF) with the potential to modulate SRF-targetgenes. Plays a crucial role in cardiogenesis and differentiationof the smooth muscle cell lineage (myogenesis) (By similarity).{ECO:0000250, ECO:0000269|PubMed:12640126}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STX8_MYOCD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STX8_MYOCD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STX8 | VTI1B, CREB3, NAPA, VTI1A, STX7, VAMP8, HECTD3, NSF, CALM1, ATP6V1B1, CLN8, STX4, VAMP4, VAMP3, VAMP7, STX6, SRPRB, STX12, CLEC12A, STX3, CEP170, NAPG, TMEM171, STX18, DTNBP1, AP2M1, LPAR1, CEP164, TMEM17, TMEM216, ERRFI1, SEC22B, STX11, STXBP6, CLINT1, STAMBPL1, AP1S2, IPPK, GDPD5, ASPH, MED21, MAP7D2, GPR156, TRDN, LMNA | MYOCD | SRF, MKL1, SMARCA4, SMAD3, SMAD2, KDM3A, MYOD1, PPP2R4, STUB1, HSPA4, HSP90AA1, NCOA3, ARRB2, GOPC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STX8_MYOCD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STX8_MYOCD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MYOCD | C0018800 | Cardiomegaly | 1 | CTD_human |