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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 36665

FusionGeneSummary for STX8_HSD17B4

check button Fusion gene summary
Fusion gene informationFusion gene name: STX8_HSD17B4
Fusion gene ID: 36665
HgeneTgene
Gene symbol

STX8

HSD17B4

Gene ID

9482

3295

Gene namesyntaxin 8hydroxysteroid 17-beta dehydrogenase 4
SynonymsCARBDBP|MFE-2|MPF-2|PRLTS1|SDR8C1
Cytomap

17p13.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-8CIP-1-associated regulator of cyclin Bperoxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratase
Modification date2018052320180522
UniProtAcc

Q9UNK0

P51659

Ensembl transtripts involved in fusion geneENST00000306357, ENST00000574431, 
ENST00000573373, 		ENST00000256216, 
ENST00000515320, ENST00000510025, 
ENST00000504811, ENST00000414835, 
ENST00000513628, ENST00000509514, 
ENST00000522415, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 2 X 3=24
# samples 64
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STX8 [Title/Abstract] AND HSD17B4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTX8

GO:0045022

early endosome to late endosome transport

10564279

HgeneSTX8

GO:1903076

regulation of protein localization to plasma membrane

18570918

TgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

TgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

TgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

TgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

TgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A2KD-01ASTX8chr17

9395146

-HSD17B4chr5

118792010

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306357ENST00000256216STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000306357ENST00000515320STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000306357ENST00000510025STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000306357ENST00000504811STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000306357ENST00000414835STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000306357ENST00000513628STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000306357ENST00000509514STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000306357ENST00000522415STX8chr17

9395146

-HSD17B4chr5

118792010

+
Frame-shiftENST00000574431ENST00000256216STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000574431ENST00000515320STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000574431ENST00000510025STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000574431ENST00000504811STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000574431ENST00000414835STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000574431ENST00000513628STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000574431ENST00000509514STX8chr17

9395146

-HSD17B4chr5

118792010

+
5CDS-intronENST00000574431ENST00000522415STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-3CDSENST00000573373ENST00000256216STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-intronENST00000573373ENST00000515320STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-5UTRENST00000573373ENST00000510025STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-5UTRENST00000573373ENST00000504811STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-5UTRENST00000573373ENST00000414835STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-intronENST00000573373ENST00000513628STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-intronENST00000573373ENST00000509514STX8chr17

9395146

-HSD17B4chr5

118792010

+
intron-intronENST00000573373ENST00000522415STX8chr17

9395146

-HSD17B4chr5

118792010

+

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FusionProtFeatures for STX8_HSD17B4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STX8

Q9UNK0

HSD17B4

P51659

Vesicle trafficking protein that functions in the earlysecretory pathway, possibly by mediating retrograde transport fromcis-Golgi membranes to the ER. Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. {ECO:0000269|PubMed:8902629,ECO:0000269|PubMed:9089413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTX8chr17:9395146chr5:118792010ENST00000306357-6842_65180237Coiled coilOntology_term=ECO:0000255
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024484_60019737DomainNote=MaoC-like
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024624_73619737DomainNote=SCP2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025484_60022762DomainNote=MaoC-like
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025624_73622762DomainNote=SCP2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023484_600-27719DomainNote=MaoC-like
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023624_736-27719DomainNote=SCP2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024734_73619737MotifMicrobody targeting signal
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025734_73622762MotifMicrobody targeting signal
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023734_736-27719MotifMicrobody targeting signal
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024164_16819737Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024196_19919737Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+02475_7619737Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025164_16822762Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025196_19922762Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+02575_7622762Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+02313_37-27719Nucleotide bindingNAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023164_168-27719Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023196_199-27719Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+02375_76-27719Nucleotide bindingNote=NAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024322_62219737RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024406_40719737Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+024510_51519737Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025322_62222762RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025406_40722762Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+025510_51522762Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+0231_305-27719RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023322_622-27719RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023406_407-27719Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000515320+023510_515-27719Region(3R)-3-hydroxydecanoyl-CoA binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTX8chr17:9395146chr5:118792010ENST00000306357-68145_207180237Domaint-SNARE coiled-coil homology
HgeneSTX8chr17:9395146chr5:118792010ENST00000306357-681_215180237Topological domainCytoplasmic
HgeneSTX8chr17:9395146chr5:118792010ENST00000306357-68233_236180237Topological domainVesicular
HgeneSTX8chr17:9395146chr5:118792010ENST00000306357-68216_232180237TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+02413_3719737Nucleotide bindingNAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+02513_3722762Nucleotide bindingNAD
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000256216+0241_30519737RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr17:9395146chr5:118792010ENST00000504811+0251_30522762RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase


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FusionGeneSequence for STX8_HSD17B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STX8_ENST00000306357_chr17_9395146_-_HSD17B4_ENST00000256216_chr5_118792010_+_898aa
MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRE
RLLLASFKNEGAEPDLIRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQN
GLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFA
RISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSR
MTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQ
ESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGV
IIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGF
GGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAI
KARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STX8_ENST00000306357_chr17_9395146_-_HSD17B4_ENST00000256216_chr5_118792010_+_2694nt
ATGGCACCGGACCCCTGGTTCTCCACATACGATTCTACTTGTCAAATTGCCCAAGAAATTGCTGAGAAAATTCAACAACGAAATCAATAT
GAAAGAAAAGGTGAAAAGGCACCAAAGCTTACCGTGACAATCAGAGCTTTGTTGCAGAACCTGAAGGAAAAGATCGCCCTTTTGAAGGAC
TTATTGCTAAGAGCTGTGTCAACACATCAGATAACACAGCTTGAAGGGGACCGAAGACAGAACCTCTTGGATGATCTTGTAACTCGAGAG
AGACTACTTCTGGCATCCTTTAAGAATGAGGGTGCCGAACCAGATCTAATCAGGTCCAGCCTGATGAGTGAAGAGGCTAAGCGAGGAGCA
CCCAACCCTTGGCTCTTTGAGGAGCCAGAGGAGACCAGAGGCTTGGGTTTTGATGAAATCCGGCAACAGCAGCAGAAAATTATCCAAGAA
CAGGACGCAGGCCTTGATGCCCTTTCCTCTATCATAAGTCGCCAAAAACAAATGGGGCAGGAAATTGGGAATGAATTGGATGAACAAAAT
GGATTGGGCCGAGCCTATGCCCTGGCTTTTGCAGAAAGAGGAGCGTTAGTTGTTGTGAATGATTTGGGAGGGGACTTCAAAGGAGTTGGT
AAAGGCTCCTTAGCTGCTGATAAGGTTGTTGAAGAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCAGTGGAAGAAGGA
GAGAAGGTTGTGAAGACAGCCCTGGATGCTTTTGGAAGAATAGATGTTGTGGTCAACAATGCTGGAATTCTGAGGGATCGTTCCTTTGCT
AGGATAAGTGATGAAGACTGGGATATAATCCACAGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGGGAACACATGAAG
AAACAGAAGTATGGAAGGATTATTATGACTTCATCAGCTTCAGGAATATATGGCAACTTTGGCCAGGCCAATTATAGTGCTGCAAAGTTG
GGTCTTCTGGGCCTTGCAAATTCTCTTGCAATTGAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAATGCGGGATCACGG
ATGACTCAGACAGTTATGCCTGAAGATCTTGTGGAAGCCCTGAAGCCAGAGTATGTGGCACCTCTTGTCCTTTGGCTTTGTCACGAGAGT
TGTGAGGAGAATGGTGGCTTGTTTGAGGTTGGAGCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCTATTGTAAGACAA
AAGAATCACCCAATGACTCCTGAGGCAGTCAAGGCTAACTGGAAGAAGATCTGTGACTTTGAGAATGCCAGCAAGCCTCAGAGTATCCAA
GAATCAACTGGCAGTATAATTGAAGTTCTGAGTAAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGTGCAACGTCTACA
GCAACATCAGGATTTGCTGGAGCTATTGGCCAGAAACTCCCTCCATTTTCTTATGCTTATACGGAACTGGAAGCTATTATGTATGCCCTT
GGAGTGGGAGCGTCAATCAAGGATCCAAAAGATTTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCCACCTTCGGAGTT
ATCATAGGTCAGAAATCTATGATGGGTGGAGGATTAGCAGAAATTCCTGGACTTTCAATCAACTTTGCAAAGGTTCTTCATGGAGAGCAG
TACTTAGAGTTATATAAACCACTTCCCAGAGCAGGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAAGGATCCGGTGTA
GTGATTATTATGGATGTCTATTCTTATTCTGAGAAGGAACTTATATGCCACAATCAGTTCTCTCTCTTTCTTGTTGGCTCTGGAGGCTTT
GGTGGAAAACGGACATCAGACAAAGTCAAGGTAGCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGATACCACCTCTCTT
AATCAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGTTTTGACAAGCCC
ATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGATTCAAGGCAATT
AAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCATTTTCAAACCAAG
GTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACACCCTCTGAGGGC
GGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAAGTAAATGCTGTA
TTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTGTACCAAGGCCCT
GCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCTCAGAAGGCATTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_STX8_ENST00000306357_chr17_9395146_-_HSD17B4_ENST00000256216_chr5_118792010_+_3461nt
GGTATAATTTACATATCATAAAGTTAACTTAAAGTAGGTTGTAGTGAGTTTACGCAGCGTGCAAGTCTCACCGCAATCTAGTGTTTTGTT
TATTGTTTTGTTTTTGAAGCAGGATAAATTTTTAAGTAACTGCTACAGAGAGGTCTTGCAGCGCTCCCACCTTCCTGGGAAAATGCTTTG
TTTCTATTTAACAATTTTAACTGAGCTTAGCAGTTCGCGTCTCTTGGTGGGAGTAGATTGCTCCAGTGTACTGTCCGCAGGGGAGCGCTT
TGCTTTCTCTGATTATAGTTCTGAGGCCCTAGCTACTCACTTTGCAAACTCCAGGCTCCGGTCGCGCACGGGACGAACTGCGGGGAGTGA
GCCGCGCGGGCCGCCGTAGTCAGCTGCTAAGAGCAGGAAGAGTCCGAGCGGCGGGCGGAGTCTGCAGGATGGCACCGGACCCCTGGTTCT
CCACATACGATTCTACTTGTCAAATTGCCCAAGAAATTGCTGAGAAAATTCAACAACGAAATCAATATGAAAGAAAAGGTGAAAAGGCAC
CAAAGCTTACCGTGACAATCAGAGCTTTGTTGCAGAACCTGAAGGAAAAGATCGCCCTTTTGAAGGACTTATTGCTAAGAGCTGTGTCAA
CACATCAGATAACACAGCTTGAAGGGGACCGAAGACAGAACCTCTTGGATGATCTTGTAACTCGAGAGAGACTACTTCTGGCATCCTTTA
AGAATGAGGGTGCCGAACCAGATCTAATCAGGTCCAGCCTGATGAGTGAAGAGGCTAAGCGAGGAGCACCCAACCCTTGGCTCTTTGAGG
AGCCAGAGGAGACCAGAGGCTTGGGTTTTGATGAAATCCGGCAACAGCAGCAGAAAATTATCCAAGAACAGGACGCAGGCCTTGATGCCC
TTTCCTCTATCATAAGTCGCCAAAAACAAATGGGGCAGGAAATTGGGAATGAATTGGATGAACAAAATGGATTGGGCCGAGCCTATGCCC
TGGCTTTTGCAGAAAGAGGAGCGTTAGTTGTTGTGAATGATTTGGGAGGGGACTTCAAAGGAGTTGGTAAAGGCTCCTTAGCTGCTGATA
AGGTTGTTGAAGAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCAGTGGAAGAAGGAGAGAAGGTTGTGAAGACAGCCC
TGGATGCTTTTGGAAGAATAGATGTTGTGGTCAACAATGCTGGAATTCTGAGGGATCGTTCCTTTGCTAGGATAAGTGATGAAGACTGGG
ATATAATCCACAGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGGGAACACATGAAGAAACAGAAGTATGGAAGGATTA
TTATGACTTCATCAGCTTCAGGAATATATGGCAACTTTGGCCAGGCCAATTATAGTGCTGCAAAGTTGGGTCTTCTGGGCCTTGCAAATT
CTCTTGCAATTGAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAATGCGGGATCACGGATGACTCAGACAGTTATGCCTG
AAGATCTTGTGGAAGCCCTGAAGCCAGAGTATGTGGCACCTCTTGTCCTTTGGCTTTGTCACGAGAGTTGTGAGGAGAATGGTGGCTTGT
TTGAGGTTGGAGCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCTATTGTAAGACAAAAGAATCACCCAATGACTCCTG
AGGCAGTCAAGGCTAACTGGAAGAAGATCTGTGACTTTGAGAATGCCAGCAAGCCTCAGAGTATCCAAGAATCAACTGGCAGTATAATTG
AAGTTCTGAGTAAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGTGCAACGTCTACAGCAACATCAGGATTTGCTGGAG
CTATTGGCCAGAAACTCCCTCCATTTTCTTATGCTTATACGGAACTGGAAGCTATTATGTATGCCCTTGGAGTGGGAGCGTCAATCAAGG
ATCCAAAAGATTTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCCACCTTCGGAGTTATCATAGGTCAGAAATCTATGA
TGGGTGGAGGATTAGCAGAAATTCCTGGACTTTCAATCAACTTTGCAAAGGTTCTTCATGGAGAGCAGTACTTAGAGTTATATAAACCAC
TTCCCAGAGCAGGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAAGGATCCGGTGTAGTGATTATTATGGATGTCTATT
CTTATTCTGAGAAGGAACTTATATGCCACAATCAGTTCTCTCTCTTTCTTGTTGGCTCTGGAGGCTTTGGTGGAAAACGGACATCAGACA
AAGTCAAGGTAGCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGATACCACCTCTCTTAATCAGGCTGCTTTGTACCGCC
TCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGTTTTGACAAGCCCATATTACATGGATTATGTACAT
TTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGATTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAG
TATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCATTTTCAAACCAAGGTCCAAGAAACTGGAGACATTG
TCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACACCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTG
TATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAAGTAAATGCTGTATTTGAGTGGCATATAACCAAAG
GCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTGTACCAAGGCCCTGCAAAAGGTGCTGCTGATACAA
CAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCTCAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCA
GAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAGCTCTGAAGGGCACACTACACTATTAATAAAAATG
GAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATTAGAACTAAGATGCAGGGGAAATTGCTTAACATTT
TCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTATTTTTACAAGGAACTATATATAAGCTAGCACATA
ATTATCCTTCTGTTCTTAGATCTGTATCTTCATAATAAAAAATTTTGCCCAAGTCCTGTTTCCTTAGAATTTGTGATAGCATTGATAAGT


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FusionGenePPI for STX8_HSD17B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STX8VTI1B, CREB3, NAPA, VTI1A, STX7, VAMP8, HECTD3, NSF, CALM1, ATP6V1B1, CLN8, STX4, VAMP4, VAMP3, VAMP7, STX6, SRPRB, STX12, CLEC12A, STX3, CEP170, NAPG, TMEM171, STX18, DTNBP1, AP2M1, LPAR1, CEP164, TMEM17, TMEM216, ERRFI1, SEC22B, STX11, STXBP6, CLINT1, STAMBPL1, AP1S2, IPPK, GDPD5, ASPH, MED21, MAP7D2, GPR156, TRDN, LMNAHSD17B4UBA5, UBC, NDRG1, MYC, GRB2, SNCA, ACAA1, SCP2, CAT, GRHPR, SSBP1, FIS1, GNB2L1, VAMP2, PEX5, PEX14, ADRB2, CASP9, BAK1, CDK7, MAPK8, HECW2, STAU1, CUL7, CCDC8, DECR1, EEF2, IDH1, NTRK1, SCARNA22, RPGRIP1, FOS, HNRNPD, HNRNPU, SORT1, RACGAP1, NF2, CDC73, PPM1A, DUSP22, DUSP4, IKZF1, DLD, DLST, PDHA1, SDHA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STX8_HSD17B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STX8_HSD17B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSD17B4C0342870Bifunctional peroxisomal enzyme deficiency4CTD_human;ORPHANET;UNIPROT
TgeneHSD17B4C0282528Peroxisomal Disorders2CTD_human
TgeneHSD17B4C0685838Gonadal dysgenesis XX type deafness2CTD_human;ORPHANET;UNIPROT
TgeneHSD17B4C0037769West Syndrome1CTD_human
TgeneHSD17B4C0043459Zellweger Syndrome1CTD_human