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Fusion gene ID: 36660 |
FusionGeneSummary for STX6_SMYD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STX6_SMYD3 | Fusion gene ID: 36660 | Hgene | Tgene | Gene symbol | STX6 | SMYD3 | Gene ID | 10228 | 64754 |
| Gene name | syntaxin 6 | SET and MYND domain containing 3 | |
| Synonyms | - | KMT3E|ZMYND1|ZNFN3A1|bA74P14.1 | |
| Cytomap | 1q25.3 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | syntaxin-6 | histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43752 | Q9H7B4 | |
| Ensembl transtripts involved in fusion gene | ENST00000258301, ENST00000469135, ENST00000542060, | ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 17 X 9 X 13=1989 |
| # samples | 4 | 31 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/1989*10)=-2.68170315555951 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STX6 [Title/Abstract] AND SMYD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6Z0-01A | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000258301 | ENST00000541742 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000258301 | ENST00000490107 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| In-frame | ENST00000258301 | ENST00000388985 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-5UTR | ENST00000258301 | ENST00000366517 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5CDS-intron | ENST00000258301 | ENST00000403792 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| intron-3CDS | ENST00000469135 | ENST00000541742 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| intron-3CDS | ENST00000469135 | ENST00000490107 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| intron-3CDS | ENST00000469135 | ENST00000388985 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| intron-5UTR | ENST00000469135 | ENST00000366517 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| intron-intron | ENST00000469135 | ENST00000403792 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000542060 | ENST00000541742 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000542060 | ENST00000490107 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-3CDS | ENST00000542060 | ENST00000388985 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-5UTR | ENST00000542060 | ENST00000366517 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
| 5UTR-intron | ENST00000542060 | ENST00000403792 | STX6 | chr1 | 180991775 | - | SMYD3 | chr1 | 246093239 | - |
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FusionProtFeatures for STX6_SMYD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STX6 | SMYD3 |
| Involved in intracellular vesicle trafficking. | Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but notmonomethylation (PubMed:15235609, PubMed:22419068). Alsomethylates 'Lys-5' of histone H4 (PubMed:22419068). Plays animportant role in transcriptional activation as a member of an RNApolymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).{ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 205_206 | 177 | 429 | Region | S-adenosyl-L-methionine binding |
| Tgene | >SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 205_206 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | >SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 205_206 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STX6 | chr1:180991775 | chr1:246093239 | ENST00000258301 | - | 1 | 8 | 41_74 | 11 | 256 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STX6 | chr1:180991775 | chr1:246093239 | ENST00000258301 | - | 1 | 8 | 163_225 | 11 | 256 | Domain | t-SNARE coiled-coil homology |
| Hgene | >STX6 | chr1:180991775 | chr1:246093239 | ENST00000258301 | - | 1 | 8 | 2_234 | 11 | 256 | Topological domain | Cytoplasmic |
| Hgene | >STX6 | chr1:180991775 | chr1:246093239 | ENST00000258301 | - | 1 | 8 | 235_255 | 11 | 256 | Transmembrane | Helical%3B Anchor for type IV membrane protein |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 4_240 | 177 | 429 | Domain | SET |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 4_240 | 118 | 370 | Domain | SET |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 4_240 | 118 | 370 | Domain | SET |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 14_16 | 177 | 429 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 14_16 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 14_16 | 118 | 370 | Region | S-adenosyl-L-methionine binding |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000388985 | - | 4 | 12 | 49_87 | 177 | 429 | Zinc finger | MYND-type |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000490107 | - | 4 | 12 | 49_87 | 118 | 370 | Zinc finger | MYND-type |
| Tgene | SMYD3 | chr1:180991775 | chr1:246093239 | ENST00000541742 | - | 4 | 12 | 49_87 | 118 | 370 | Zinc finger | MYND-type |
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FusionGeneSequence for STX6_SMYD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000541742_chr1_246093239_-_263aa MSMEDPFFVVKGXSATLSPSVMRRCRKLVLAYIPVSLCSITAVTPTVRLCSMGPTSYCEQSETSRWERSSPSATWICXXPVRSAGSSXGT STALNVTVSVAKPRTRMLICXLVMSKYGRKFKNPXKKLKNXRHTGSGSRFWPCARQSXAAILNGFPISTSTSXRCSTAPWMPASTSACWR >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000490107_chr1_246093239_-_263aa MSMEDPFFVVKGXSATLSPSVMRRCRKLVLAYIPVSLCSITAVTPTVRLCSMGPTSYCEQSETSRWERSSPSATWICXXPVRSAGSSXGT STALNVTVSVAKPRTRMLICXLVMSKYGRKFKNPXKKLKNXRHTGSGSRFWPCARQSXAAILNGFPISTSTSXRCSTAPWMPASTSACWR >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000388985_chr1_246093239_-_263aa MSMEDPFFVVKGXSATLSPSVMRRCRKLVLAYIPVSLCSITAVTPTVRLCSMGPTSYCEQSETSRWERSSPSATWICXXPVRSAGSSXGT STALNVTVSVAKPRTRMLICXLVMSKYGRKFKNPXKKLKNXRHTGSGSRFWPCARQSXAAILNGFPISTSTSXRCSTAPWMPASTSACWR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000541742_chr1_246093239_-_791nt ATGTCCATGGAGGACCCCTTCTTTGTGGTGAAAGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTG GCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAG TCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACC AGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAG TTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCA ATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGG AAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAG TTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCA >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000490107_chr1_246093239_-_791nt ATGTCCATGGAGGACCCCTTCTTTGTGGTGAAAGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTG GCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAG TCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACC AGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAG TTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCA ATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGG AAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAG TTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCA >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000388985_chr1_246093239_-_791nt ATGTCCATGGAGGACCCCTTCTTTGTGGTGAAAGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTG GCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAG TCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACC AGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAG TTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCA ATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGG AAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAG TTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000541742_chr1_246093239_-_1252nt CGGGACTGGAGGCTGCCGAGGGGGCCGGCGCCCGAGTCCGGGATTCGGCCAGTGGTGCTGAGCGAGTGCTGGACCAGCGGCCGTCCTGTG CACCTGGCCTGTGCGCGTGCCCGCTGCTCGGCTTCACCCAGACTAAGGCGCGGGCAGCTGCGGGAACAGGCGGGGTGGGCGGAGGGAGAC CGGGAGGCACGGGCGCCCTGTGCGCGGAGGAGGTGAAGGCGGCCGGGGCCGGGACGCCATGTCCATGGAGGACCCCTTCTTTGTGGTGAA AGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCAC AGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACC ATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGC CAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTG AAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTAC CAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAG CCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTT CCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTA CTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTAT TGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGAC >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000490107_chr1_246093239_-_1250nt CGGGACTGGAGGCTGCCGAGGGGGCCGGCGCCCGAGTCCGGGATTCGGCCAGTGGTGCTGAGCGAGTGCTGGACCAGCGGCCGTCCTGTG CACCTGGCCTGTGCGCGTGCCCGCTGCTCGGCTTCACCCAGACTAAGGCGCGGGCAGCTGCGGGAACAGGCGGGGTGGGCGGAGGGAGAC CGGGAGGCACGGGCGCCCTGTGCGCGGAGGAGGTGAAGGCGGCCGGGGCCGGGACGCCATGTCCATGGAGGACCCCTTCTTTGTGGTGAA AGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCAC AGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACC ATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGC CAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTG AAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTAC CAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAG CCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTT CCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTA CTTTTAGAAGAATGCGACGCCAACATCAGAGCATCCTAAGGGAACGCAGTCAGAGGGAAATACGGCGTGTGTCTTTGTTGAATGCCTTAT TGAGGTCACACACTCTATGCTTTGTTAGCTGTGTGAACCTCTCCTATTGGAAATTCTGTTCCGTGTTTGTGTAGGTAAATAAAGGCAGAC >In-frame_STX6_ENST00000258301_chr1_180991775_-_SMYD3_ENST00000388985_chr1_246093239_-_1029nt CGGGACTGGAGGCTGCCGAGGGGGCCGGCGCCCGAGTCCGGGATTCGGCCAGTGGTGCTGAGCGAGTGCTGGACCAGCGGCCGTCCTGTG CACCTGGCCTGTGCGCGTGCCCGCTGCTCGGCTTCACCCAGACTAAGGCGCGGGCAGCTGCGGGAACAGGCGGGGTGGGCGGAGGGAGAC CGGGAGGCACGGGCGCCCTGTGCGCGGAGGAGGTGAAGGCGGCCGGGGCCGGGACGCCATGTCCATGGAGGACCCCTTCTTTGTGGTGAA AGGGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCAC AGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACC ATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGC CAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTG AAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTAC CAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAG CCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTT CCCCAAGCAATGAAGAATCTGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGCCTGATTGAAGATTTGATTCTA |
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FusionGenePPI for STX6_SMYD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STX6 | VAMP4, VAMP3, VAMP8, STX7, SNAP23, NSF, VPS53, VPS52, VPS51, VPS54, CSGALNACT1, MARCH2, PSMA3, STX4, GOSR2, NAPB, ENO1, MOV10, NXF1, VAMP7, VTI1B, VPS45, NAPA, STX18, GOSR1, GTF3C2, CUX1, STX5, GTF3C1, B3GAT3, STX12, BNIP1, SCFD1, UGT8, SNAP29, STX8, NAPG, GTF3C3, VTI1A, NBAS, STX3, STX10, STXBP5, TSPAN3, CLEC12A, TMEM17, TMEM216, TMEM200A, STX11, MRAP2, FAM171B, STXBP6, SEC22B, TPCN2, COG6, HAUS1, TRIM25, LMNA | SMYD3 | MEST, HELZ, POLR2A, HSP90AA1, HIST3H3, ESR1, EZH2, EED, APP, CAMK2B, NDUFAB1, NFYB, CYP39A1, VANGL1, H3F3C, TRIT1, ZNF557, CDC37, HSP90AB1, HSP90AB4P, HSP90AB3P, HSP90AA5P, MAGED4B, KDM3B, RCAN3, PLCB3, TRMT2A, KMT2E |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STX6_SMYD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STX6_SMYD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STX6 | C0038868 | Progressive supranuclear palsy | 1 | CTD_human |
| Hgene | STX6 | C1866282 | CEROID LIPOFUSCINOSIS, NEURONAL, 6 | 1 | CTD_human |
| Tgene | SMYD3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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