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Fusion gene ID: 36640 |
FusionGeneSummary for STX18_LYAR |
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Fusion gene information | Fusion gene name: STX18_LYAR | Fusion gene ID: 36640 | Hgene | Tgene | Gene symbol | STX18 | LYAR | Gene ID | 53407 | 55646 |
Gene name | syntaxin 18 | Ly1 antibody reactive | |
Synonyms | Ufe1 | ZC2HC2|ZLYAR | |
Cytomap | 4p16.3-p16.2 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | syntaxin-18cell growth-inhibiting gene 9 protein | cell growth-regulating nucleolar proteinLy1 antibody reactive homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9P2W9 | Q9NX58 | |
Ensembl transtripts involved in fusion gene | ENST00000505286, ENST00000306200, | ENST00000343470, ENST00000452476, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 4=120 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STX18 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-3P-A9WA-01A | STX18 | chr4 | 4440121 | - | LYAR | chr4 | 4288299 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000505286 | ENST00000343470 | STX18 | chr4 | 4440121 | - | LYAR | chr4 | 4288299 | - |
5CDS-5UTR | ENST00000505286 | ENST00000452476 | STX18 | chr4 | 4440121 | - | LYAR | chr4 | 4288299 | - |
5CDS-5UTR | ENST00000306200 | ENST00000343470 | STX18 | chr4 | 4440121 | - | LYAR | chr4 | 4288299 | - |
5CDS-5UTR | ENST00000306200 | ENST00000452476 | STX18 | chr4 | 4440121 | - | LYAR | chr4 | 4288299 | - |
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FusionProtFeatures for STX18_LYAR |
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Hgene | Tgene |
STX18 | LYAR |
Syntaxin that may be involved in targeting and fusion ofGolgi-derived retrograde transport vesicles with the ER.{ECO:0000269|PubMed:15029241}. | Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STX18_LYAR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STX18_LYAR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STX18 | ZW10, RINT1, SNAP23, SCFD1, SEC22B, DISC1, NUPR1, VTI1B, STX6, SNAP29, STX7, USE1, SRPRB, STX12, CLEC12A, ZWINT, BNIP1, LDOC1L, NBAS, STX5, FUT8, SNAP47, VAMP4, STX8, BET1, VAMP8, IFT57, TMEM216, RACGAP1, HNRNPA1L2, CCDC107, SCFD2, BET1L, TEX28, CHRM3, TPTE, CLUAP1 | LYAR | RPL23A, MYBBP1A, TWF2, KRT85, DHX57, RPL3, TSR1, BRIX1, KRT31, RPS9, GTPBP4, RPL18A, DHX9, RPS3A, RPL21, NAT10, NPM1, GNL2, DDX27, EIF3I, KRT82, EBNA1BP2, RPL31, KPNA1, SRP14, DDX21, ZHX1, ZBTB16, NOP56, OAS3, EIF2AK2, HDGF, TERF1, TERF2, CUL3, CUL1, COPS5, CAND1, GRK5, ESR1, MDC1, PAXIP1, VCP, FGF18, CD2, PHF20L1, ADSSL1, PRKRA, SDCBP2, BEND7, PHF6, RNF2, PRR11, ILF2, EPB41L3, ERCC4, IFI16, CEP152, HNRNPU, NCBP1, RPL10, RFWD3, FAM83H, RNF138, ZNF746, RPL37A, MAGEB10, RPL30, NCL, BRD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STX18_LYAR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STX18_LYAR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |