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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36619

FusionGeneSummary for STT3B_ZNF860

check button Fusion gene summary
Fusion gene informationFusion gene name: STT3B_ZNF860
Fusion gene ID: 36619
HgeneTgene
Gene symbol

STT3B

ZNF860

Gene ID

201595

344787

Gene nameSTT3B, catalytic subunit of the oligosaccharyltransferase complexzinc finger protein 860
SynonymsCDG1X|SIMP|STT3-B-
Cytomap

3p23

3p23-p22.3

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog BSTT3B, subunit of the oligosaccharyltransferase complex (catalytic)dolichyl-diphosphooligosaccharide protein glzinc finger protein 860
Modification date2018052320180523
UniProtAcc

Q8TCJ2

A6NHJ4

Ensembl transtripts involved in fusion geneENST00000453168, ENST00000295770, 
ENST00000489408, ENST00000360311, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: STT3B [Title/Abstract] AND ZNF860 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A1AD-01ASTT3Bchr3

31574804

+ZNF860chr3

32030152

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000453168ENST00000489408STT3Bchr3

31574804

+ZNF860chr3

32030152

+
3UTR-5UTRENST00000453168ENST00000360311STT3Bchr3

31574804

+ZNF860chr3

32030152

+
5CDS-3UTRENST00000295770ENST00000489408STT3Bchr3

31574804

+ZNF860chr3

32030152

+
5CDS-5UTRENST00000295770ENST00000360311STT3Bchr3

31574804

+ZNF860chr3

32030152

+

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FusionProtFeatures for STT3B_ZNF860


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STT3B

Q8TCJ2

ZNF860

A6NHJ4

Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. N-glycosylation occurscotranslationally and the complex associates with the Sec61complex at the channel-forming translocon complex that mediatesprotein translocation across the endoplasmic reticulum (ER). STT3Bis present in a small subset of OST complexes and mediates bothcotranslational and post-translational N-glycosylation of targetproteins: STT3B-containing complexes are required for efficientpost-translational glycosylation and while they are less competentthan STT3A-containing complexes for cotranslational glycosylation,they have the ability to mediate glycosylation of some nascentsites that are not accessible for STT3A. STT3B-containingcomplexes also act post-translationally and mediate modificationof skipped glycosylation sites in unfolded proteins. Plays a rolein ER-associated degradation (ERAD) pathway that mediatesubiquitin-dependent degradation of misfolded endoplasmic reticulumproteins by mediating N-glycosylation of unfolded proteins, whichare then recognized by the ERAD pathway and targeted fordegradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.{ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976,ECO:0000305}. May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STT3B_ZNF860


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STT3B_ZNF860


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STT3BTMEM173, UNC93B1, AUP1, FBXO6, RPN1, RPN2, DDOST, MAGT1, RPS19, RPS15, SYNCRIP, PTRH2, SRSF7, CORO1C, HADHA, PLP2, ABCC1, CACNA2D1, OST4, UNK, NTRK1, KRTCAP2, TP53, TCTN2, TCTN3, FBF1, EVC2, TCTN1, TMEM216, TMEM67, RAB7A, VAPA, TMEM258, MLEC, CLPTM1, EDEM3, TRIM25ZNF860SHMT2, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STT3B_ZNF860


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STT3B_ZNF860


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource