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Fusion gene ID: 36619 |
FusionGeneSummary for STT3B_ZNF860 |
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Fusion gene information | Fusion gene name: STT3B_ZNF860 | Fusion gene ID: 36619 | Hgene | Tgene | Gene symbol | STT3B | ZNF860 | Gene ID | 201595 | 344787 |
Gene name | STT3B, catalytic subunit of the oligosaccharyltransferase complex | zinc finger protein 860 | |
Synonyms | CDG1X|SIMP|STT3-B | - | |
Cytomap | 3p23 | 3p23-p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog BSTT3B, subunit of the oligosaccharyltransferase complex (catalytic)dolichyl-diphosphooligosaccharide protein gl | zinc finger protein 860 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TCJ2 | A6NHJ4 | |
Ensembl transtripts involved in fusion gene | ENST00000453168, ENST00000295770, | ENST00000489408, ENST00000360311, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: STT3B [Title/Abstract] AND ZNF860 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-DK-A1AD-01A | STT3B | chr3 | 31574804 | + | ZNF860 | chr3 | 32030152 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000453168 | ENST00000489408 | STT3B | chr3 | 31574804 | + | ZNF860 | chr3 | 32030152 | + |
3UTR-5UTR | ENST00000453168 | ENST00000360311 | STT3B | chr3 | 31574804 | + | ZNF860 | chr3 | 32030152 | + |
5CDS-3UTR | ENST00000295770 | ENST00000489408 | STT3B | chr3 | 31574804 | + | ZNF860 | chr3 | 32030152 | + |
5CDS-5UTR | ENST00000295770 | ENST00000360311 | STT3B | chr3 | 31574804 | + | ZNF860 | chr3 | 32030152 | + |
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FusionProtFeatures for STT3B_ZNF860 |
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Hgene | Tgene |
STT3B | ZNF860 |
Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. N-glycosylation occurscotranslationally and the complex associates with the Sec61complex at the channel-forming translocon complex that mediatesprotein translocation across the endoplasmic reticulum (ER). STT3Bis present in a small subset of OST complexes and mediates bothcotranslational and post-translational N-glycosylation of targetproteins: STT3B-containing complexes are required for efficientpost-translational glycosylation and while they are less competentthan STT3A-containing complexes for cotranslational glycosylation,they have the ability to mediate glycosylation of some nascentsites that are not accessible for STT3A. STT3B-containingcomplexes also act post-translationally and mediate modificationof skipped glycosylation sites in unfolded proteins. Plays a rolein ER-associated degradation (ERAD) pathway that mediatesubiquitin-dependent degradation of misfolded endoplasmic reticulumproteins by mediating N-glycosylation of unfolded proteins, whichare then recognized by the ERAD pathway and targeted fordegradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.{ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976,ECO:0000305}. | May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STT3B_ZNF860 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STT3B_ZNF860 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STT3B | TMEM173, UNC93B1, AUP1, FBXO6, RPN1, RPN2, DDOST, MAGT1, RPS19, RPS15, SYNCRIP, PTRH2, SRSF7, CORO1C, HADHA, PLP2, ABCC1, CACNA2D1, OST4, UNK, NTRK1, KRTCAP2, TP53, TCTN2, TCTN3, FBF1, EVC2, TCTN1, TMEM216, TMEM67, RAB7A, VAPA, TMEM258, MLEC, CLPTM1, EDEM3, TRIM25 | ZNF860 | SHMT2, NXF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STT3B_ZNF860 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STT3B_ZNF860 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |