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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36618

FusionGeneSummary for STT3B_EMC3

check button Fusion gene summary
Fusion gene informationFusion gene name: STT3B_EMC3
Fusion gene ID: 36618
HgeneTgene
Gene symbol

STT3B

EMC3

Gene ID

201595

55831

Gene nameSTT3B, catalytic subunit of the oligosaccharyltransferase complexER membrane protein complex subunit 3
SynonymsCDG1X|SIMP|STT3-BPOB|TMEM111
Cytomap

3p23

3p25.3

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog BSTT3B, subunit of the oligosaccharyltransferase complex (catalytic)dolichyl-diphosphooligosaccharide protein glER membrane protein complex subunit 330 kDa proteinpartial optokinetic response btransmembrane protein 111
Modification date2018052320180523
UniProtAcc

Q8TCJ2

Q9P0I2

Ensembl transtripts involved in fusion geneENST00000453168, ENST00000295770, 
ENST00000245046, ENST00000497557, 
ENST00000429759, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STT3B [Title/Abstract] AND EMC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-A7TL-01ASTT3Bchr3

31574804

+EMC3chr3

10019130

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000453168ENST00000245046STT3Bchr3

31574804

+EMC3chr3

10019130

-
3UTR-5UTRENST00000453168ENST00000497557STT3Bchr3

31574804

+EMC3chr3

10019130

-
3UTR-5UTRENST00000453168ENST00000429759STT3Bchr3

31574804

+EMC3chr3

10019130

-
In-frameENST00000295770ENST00000245046STT3Bchr3

31574804

+EMC3chr3

10019130

-
5CDS-5UTRENST00000295770ENST00000497557STT3Bchr3

31574804

+EMC3chr3

10019130

-
5CDS-5UTRENST00000295770ENST00000429759STT3Bchr3

31574804

+EMC3chr3

10019130

-

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FusionProtFeatures for STT3B_EMC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STT3B

Q8TCJ2

EMC3

Q9P0I2

Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. N-glycosylation occurscotranslationally and the complex associates with the Sec61complex at the channel-forming translocon complex that mediatesprotein translocation across the endoplasmic reticulum (ER). STT3Bis present in a small subset of OST complexes and mediates bothcotranslational and post-translational N-glycosylation of targetproteins: STT3B-containing complexes are required for efficientpost-translational glycosylation and while they are less competentthan STT3A-containing complexes for cotranslational glycosylation,they have the ability to mediate glycosylation of some nascentsites that are not accessible for STT3A. STT3B-containingcomplexes also act post-translationally and mediate modificationof skipped glycosylation sites in unfolded proteins. Plays a rolein ER-associated degradation (ERAD) pathway that mediatesubiquitin-dependent degradation of misfolded endoplasmic reticulumproteins by mediating N-glycosylation of unfolded proteins, whichare then recognized by the ERAD pathway and targeted fordegradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.{ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STT3B_EMC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STT3B_ENST00000295770_chr3_31574804_+_EMC3_ENST00000245046_chr3_10019130_-_315aa
MAEPSAPESKHKSSLNSSPWSGLMALGNSRHGHHGPGAQCAHKAAGGAAPPKPAPAGLSGGLSQPAGWQSLLSFTILFLAWLAGFSSRLF
AVIRFESIIHEFDPCQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGW
INMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STT3B_ENST00000295770_chr3_31574804_+_EMC3_ENST00000245046_chr3_10019130_-_945nt
ATGGCGGAGCCCTCGGCCCCGGAGAGCAAGCACAAGTCGTCCCTCAACTCGTCCCCGTGGAGTGGCCTCATGGCCCTGGGAAACAGCCGG
CACGGCCACCACGGGCCCGGGGCCCAGTGCGCGCACAAGGCGGCGGGCGGCGCGGCGCCGCCGAAGCCGGCCCCGGCGGGGCTGTCCGGG
GGGCTGTCGCAGCCGGCTGGGTGGCAGTCGCTTCTCTCCTTCACCATCCTCTTCCTGGCCTGGCTTGCCGGCTTCAGCTCGCGCCTCTTC
GCCGTCATCCGCTTCGAAAGCATCATCCACGAGTTCGACCCGTGTCAAGTCCTAATTCGAAGCAGAGTCCTCAGGGAAAATGGAAAATAC
ATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTTTTCAAAAAAACTAAACGGAAGGTAGTGCCA
CCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAATGTCCTCCCTATGATTCTTATTGGTGGATGG
ATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGTTTTAAGCCTATGTTACAGCAAGGAATCGAG
CTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTTGGGCTTCGGAGCATTTACTCTCTGATTCTG
GGCCAAGATAATGCCGCTGACCAATCACGAATGATGCAGGAGCAGATGACGGGAGCAGCCATGGCCATGCCCGCAGACACAAACAAAGCT
TTCAAGACAGAGTGGGAAGCTTTGGAGCTGACGGATCACCAGTGGGCACTAGATGATGTCGAAGAAGAGCTCATGGCCAAAGACCTCCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_STT3B_ENST00000295770_chr3_31574804_+_EMC3_ENST00000245046_chr3_10019130_-_2686nt
GCGGCCGCTGCTGAGGCGGAGACTCCCCGCCGCCGCTTCCTCCACCCCCAGTCCGCCGGCCTCGCGGCGCTGAGGGCGGGAGCGCGCAGA
GCTCTTCCCTCCTCCTTTTTCTTCCTCCTCCTCCTCCTCCTCCGGGTCCCCGCCCAGCACCCCTCGCACCAGGCGGCGGCGGCGGAGGAG
GAGAGCTAGACCCGCCGCCGGGGCACAACATGGCGGAGCCCTCGGCCCCGGAGAGCAAGCACAAGTCGTCCCTCAACTCGTCCCCGTGGA
GTGGCCTCATGGCCCTGGGAAACAGCCGGCACGGCCACCACGGGCCCGGGGCCCAGTGCGCGCACAAGGCGGCGGGCGGCGCGGCGCCGC
CGAAGCCGGCCCCGGCGGGGCTGTCCGGGGGGCTGTCGCAGCCGGCTGGGTGGCAGTCGCTTCTCTCCTTCACCATCCTCTTCCTGGCCT
GGCTTGCCGGCTTCAGCTCGCGCCTCTTCGCCGTCATCCGCTTCGAAAGCATCATCCACGAGTTCGACCCGTGTCAAGTCCTAATTCGAA
GCAGAGTCCTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTTT
TCAAAAAAACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAATG
TCCTCCCTATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGTT
TTAAGCCTATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTTG
GGCTTCGGAGCATTTACTCTCTGATTCTGGGCCAAGATAATGCCGCTGACCAATCACGAATGATGCAGGAGCAGATGACGGGAGCAGCCA
TGGCCATGCCCGCAGACACAAACAAAGCTTTCAAGACAGAGTGGGAAGCTTTGGAGCTGACGGATCACCAGTGGGCACTAGATGATGTCG
AAGAAGAGCTCATGGCCAAAGACCTCCACTTCGAAGGCATGTTCAAAAAGGAATTACAGACCTCTATTTTTTGAAGACCGAGCAGGGATT
AGCTGTGTCAGGAACTTGGAGTTGCACTTAACCTTGTAACTTTGTTTGGAGCTGGCACCTCTTGAAATAAAAAGGAGGATGCACGAGCTG
GCAGGCATGCAGCAAGGCTTGTTCTTGTCTGGGCTGGGTTCCCCTTTATGTTTGAAACTAGAGGAAATAGGAGTATGCTGGGCAACTTGT
TATTTTTAAAATGTTGTAAATGTTCCTTCTGGTGACTCTAGTAATGAAAGTCAGAGAAAGGGGGAAACCTCAGGCTACTGATAATATATA
AAATCTTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGGATTTTGGGAGGCTGAGGCGGGTGGGTCACGAGATCAGGAGTTCAAGAT
CAGCCTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAAAATTAGCCGGGCGTGGTGGTGGGCACCTGTAATCCCAGCT
ACTTGGGAGGCTGAGGCAGAGAACTGCTTAAACCTAGGAGGCGGAGGATGCAGTGAGCTGACATCGTGCCACTGCGCTCCAGCCTGGGCG
ACAGAGCAAAACTCCATCTGAAAAAAAAAAAAAAATATATATATATATATATATATATCTATCTTAGCAGAAGCCCAGTCTTCGAAGGAA
GCATTGTTAATTATAGCTAATGATTATGTGCAGTCAGCCTGACATCTAGCCACAGTAAACTCCTGTTTTCTTGGGATCCAAACACCCTGT
GTTTTACCATTAGTTTTGTTAGTATTGTTAACTTTCTTTACACAAGTAAACCATTTCCACTACCAAAGGTTTAGAAACTATGGATGAACA
AAATGAATCTCCCTGTTCATTTTGAGCCTACATAGACATAGAGACCAAATATGTCAAAACCTTATTCAAATAAACTCTCTTCAGAGTGAA
TACCCAGGGTCAGGACAGACTCAGCAAACCTTCTATATCACTTAATTCTGCCCAGTGAAAATCAGTGACCCTGAGGCACTGCCAGATTCT
AAAGTGCCTTTGGGATCATCAGAGACTGTCTATAAATAATGCAAAATCTTGATCTGGATGTCAGTGTATCAAATCTTATCAAATCCATTG
ACAAATCAGTGGTGCTATACTGGAAATGGCTACTCCTTTGGATGAAGGACCTCATTTCCCAGTTGCTTGGAACAAAAGAGAATTTACATA
TTGCTGTAAGAAGGGAGAGACGGCAGTTGTTGGTAGACACACAGATAAGGGTGCCCAAGAATAATTCTGTCTGGATTAAAGGTCCCAGGG
AAGTGACGGTGCCATTTCTGTACCAAGAGGTGAATATAATTTGCATGTTGAGTGCAGTAATTAAGAACAAACGACTCGACTCCACAAATT
AAACCGTCCTGTTTTCTCTTCTTTGCCTGTGAAAGTGTTGCCTCTGTAAGTCACTAACAACCTTCTGCCAGCAGTTGACTGTCTATCTTG


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FusionGenePPI for STT3B_EMC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STT3BTMEM173, UNC93B1, AUP1, FBXO6, RPN1, RPN2, DDOST, MAGT1, RPS19, RPS15, SYNCRIP, PTRH2, SRSF7, CORO1C, HADHA, PLP2, ABCC1, CACNA2D1, OST4, UNK, NTRK1, KRTCAP2, TP53, TCTN2, TCTN3, FBF1, EVC2, TCTN1, TMEM216, TMEM67, RAB7A, VAPA, TMEM258, MLEC, CLPTM1, EDEM3, TRIM25EMC3UBC, FBXO6, CCDC8, EGFR, EMC7, EMC8, DERL2, EMC1, EMC9, UBQLN2, EMC2, MMGT1, UBAC2, EMC4, EMC10, SDF2L1, ATP1B4, ENPP6, OFD1, TCTN2, TCTN3, RPGRIP1L, DCTN1, TMEM237, TCTN1, TMEM17, TMEM216, TMEM67, CTDNEP1, TPTE, TRDN, IFNA21, SCGB1D1, PDIA4, SLC18A1, SLC4A8, CSGALNACT2, GNRH1, SLC17A2, EDEM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STT3B_EMC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STT3B_EMC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource