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Fusion gene ID: 36617 |
FusionGeneSummary for STT3A_UBQLN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STT3A_UBQLN4 | Fusion gene ID: 36617 | Hgene | Tgene | Gene symbol | STT3A | UBQLN4 | Gene ID | 3703 | 56893 |
| Gene name | STT3A, catalytic subunit of the oligosaccharyltransferase complex | ubiquilin 4 | |
| Synonyms | ITM1|STT3-A|TMC | A1U|A1Up|C1orf6|CIP75|UBIN | |
| Cytomap | 11q24.2 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3AB5STT3, subunit of the oligosaccharyltransferase complex, homolog ASTT3A, cataylic subunit of the oligosaccharyltransferase complexSTT3A, subunit of the oligosaccharyltransfer | ubiquilin-4ataxin-1 interacting ubiquitin-like proteinataxin-1 ubiquitin-like interacting proteinataxin-1 ubiquitin-like-interacting protein A1Uconnexin43-interacting protein of 75 kDa | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P46977 | Q9NRR5 | |
| Ensembl transtripts involved in fusion gene | ENST00000392708, ENST00000529196, ENST00000531491, ENST00000526364, | ENST00000368309, ENST00000472638, | |
| Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STT3A [Title/Abstract] AND UBQLN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE837748 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000392708 | ENST00000368309 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| 5CDS-intron | ENST00000392708 | ENST00000472638 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| 5CDS-intron | ENST00000529196 | ENST00000368309 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| 5CDS-intron | ENST00000529196 | ENST00000472638 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| 5CDS-intron | ENST00000531491 | ENST00000368309 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| 5CDS-intron | ENST00000531491 | ENST00000472638 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| intron-intron | ENST00000526364 | ENST00000368309 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
| intron-intron | ENST00000526364 | ENST00000472638 | STT3A | chr11 | 125475574 | + | UBQLN4 | chr1 | 156013479 | - |
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FusionProtFeatures for STT3A_UBQLN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STT3A | UBQLN4 |
| Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. N-glycosylation occurscotranslationally and the complex associates with the Sec61complex at the channel-forming translocon complex that mediatesprotein translocation across the endoplasmic reticulum (ER). SST3Aseems to be involved in complex substrate specificity. STT3A ispresent in the majority of OST complexes and mediatescotranslational N-glycosylation of most sites on target proteins,while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sitesthat have been skipped by STT3A. {ECO:0000250|UniProtKB:F1PJP5,ECO:0000269|PubMed:19167329, ECO:0000305}. | Plays a role in the regulation of protein degradationvia the ubiquitin-proteasome system (UPS). Mediates theproteasomal targeting of misfolded or accumulated proteins fordegradation by binding (via UBA domain) to their polyubiquitinchains and by interacting (via ubiquitin-like domain) with thesubunits of the proteasome (Ref. 6). Plays a role in theregulation of the proteasomal degradation of non-ubiquitinatedGJA1 (By similarity). Acts as an adapter protein that recruitsUBQLN1 to the autophagy machinery. Mediates the association ofUBQLN1 with autophagosomes and the autophagy-related protein LC3(MAP1LC3A/B/C) and may assist in the maturation of autophagosomesto autolysosomes by mediating autophagosome-lysosome fusion(PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8,ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STT3A_UBQLN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STT3A_UBQLN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STT3A_UBQLN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STT3A_UBQLN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STT3A | C3810062 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iw | 1 | ORPHANET;UNIPROT |
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