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Fusion gene ID: 36595 |
FusionGeneSummary for STRN3_EGLN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRN3_EGLN3 | Fusion gene ID: 36595 | Hgene | Tgene | Gene symbol | STRN3 | EGLN3 | Gene ID | 29966 | 112399 |
| Gene name | striatin 3 | egl-9 family hypoxia inducible factor 3 | |
| Synonyms | PPP2R6B|S/G2NA|SG2NA | HIFP4H3|HIFPH3|PHD3 | |
| Cytomap | 14q12 | 14q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | striatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3 | egl nine homolog 3HIF-PH3HIF-prolyl hydroxylase 3HPH-1HPH-3egl nine-like protein 3 isoformhypoxia-inducible factor prolyl hydroxylase 3prolyl hydroxylase domain-containing protein 3 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q13033 | Q9H6Z9 | |
| Ensembl transtripts involved in fusion gene | ENST00000355683, ENST00000357479, ENST00000366206, | ENST00000250457, ENST00000553215, ENST00000547327, ENST00000557521, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 4 X 3 X 4=48 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/350*10)=-1.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STRN3 [Title/Abstract] AND EGLN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EGLN3 | GO:0018126 | protein hydroxylation | 19584355 |
| Tgene | EGLN3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 11598268 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-78-8660-01A | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355683 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000355683 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000355683 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000355683 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000357479 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000357479 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000357479 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000357479 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-3CDS | ENST00000366206 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-3CDS | ENST00000366206 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-intron | ENST00000366206 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-intron | ENST00000366206 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
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FusionProtFeatures for STRN3_EGLN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRN3 | EGLN3 |
| Binds calmodulin in a calcium dependent manner. Mayfunction as scaffolding or signaling protein. | Cellular oxygen sensor that catalyzes, under normoxicconditions, the post-translational formation of 4-hydroxyprolinein hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates aspecific proline found in each of the oxygen-dependent degradation(ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A.Also hydroxylates HIF2A. Has a preference for the CODD site forboth HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3appears to require prior hydroxylation on the CODD site.Hydroxylated HIFs are then targeted for proteasomal degradationvia the von Hippel-Lindau ubiquitination complex. Under hypoxicconditions, the hydroxylation reaction is attenuated allowing HIFsto escape degradation resulting in their translocation to thenucleus, heterodimerization with HIF1B, and increased expressionof hypoxy-inducible genes. EGLN3 is the most important isozyme inlimiting physiological activation of HIFs (particularly HIF2A) inhypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis.Under normoxia, hydroxylates and regulates the stability of ADRB2.Regulator of cardiomyocyte and neuronal apoptosis. Incardiomyocytes, inhibits the anti-apoptotic effect of BCL2 bydisrupting the BAX-BCL2 complex. In neurons, has a NGF-inducedproapoptotic effect, probably through regulating CASP3 activity.Also essential for hypoxic regulation of neutrophilicinflammation. Plays a crucial role in DNA damage response (DDR) byhydroxylating TELO2, promoting its interaction with ATR which isrequired for activation of the ATR/CHK1/p53 pathway. Targetproteins are preferentially recognized via a LXXLAP motif.{ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324,ECO:0000269|PubMed:16098468, ECO:0000269|PubMed:19584355,ECO:0000269|PubMed:20849813, ECO:0000269|PubMed:20978507,ECO:0000269|PubMed:21317538, ECO:0000269|PubMed:21483450,ECO:0000269|PubMed:21575608, ECO:0000269|PubMed:21620138,ECO:0000269|PubMed:22797300}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 6_13 | 94 | 714 | Compositional bias | Note=Poly-Gly |
| Hgene | STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 6_13 | 94 | 798 | Compositional bias | Note=Poly-Gly |
| Hgene | STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 71_79 | 94 | 714 | Region | Caveolin-binding |
| Hgene | STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 71_79 | 94 | 798 | Region | Caveolin-binding |
| Tgene | >EGLN3 | chr14:31495110 | chr14:34400421 | ENST00000250457 | - | 0 | 5 | 116_214 | 119 | 240 | Domain | Fe2OG dioxygenase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 77_136 | 94 | 714 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 77_136 | 94 | 798 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 166_183 | 94 | 714 | Region | Calmodulin-binding |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 166_183 | 94 | 798 | Region | Calmodulin-binding |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 478_517 | 94 | 714 | Repeat | Note=WD 1 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 531_570 | 94 | 714 | Repeat | Note=WD 2 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 584_623 | 94 | 714 | Repeat | Note=WD 3 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 679_718 | 94 | 714 | Repeat | Note=WD 4 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 721_760 | 94 | 714 | Repeat | Note=WD 5 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000355683 | - | 1 | 16 | 767_796 | 94 | 714 | Repeat | Note=WD 6 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 478_517 | 94 | 798 | Repeat | Note=WD 1 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 531_570 | 94 | 798 | Repeat | Note=WD 2 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 584_623 | 94 | 798 | Repeat | Note=WD 3 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 679_718 | 94 | 798 | Repeat | Note=WD 4 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 721_760 | 94 | 798 | Repeat | Note=WD 5 |
| Hgene | >STRN3 | chr14:31495110 | chr14:34400421 | ENST00000357479 | - | 1 | 18 | 767_796 | 94 | 798 | Repeat | Note=WD 6 |
| Tgene | EGLN3 | chr14:31495110 | chr14:34400421 | ENST00000250457 | - | 0 | 5 | 62_73 | 119 | 240 | Region | Beta(2)beta(3) 'finger-like' loop |
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FusionGeneSequence for STRN3_EGLN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_215aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATR >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_215aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATR >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_215aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATR >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_215aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_645nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGC ATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATA GCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGA TATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCC >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_645nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGC ATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATA GCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGA TATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCC >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_645nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGC ATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATA GCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGA TATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCC >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_645nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGC ATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATA GCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGA TATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_2521nt AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTT CGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGG ATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGG AACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAG AAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAA CGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACAT CCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAAC TCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCG AGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCAC AGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTG GGGTTTCTGGAGAATTATCACAACCTAATGACATTAATACCTCTAGAAAGGGCTGCTGTCATAGTGAACAATTTATAAGTGTCCCATGGG GCAGACACTCCTTTTTTCCCAGTCCTGCAACCTGGATTTTCTGCCTCAGCCCCATTTTGCTGAAAATAATGACTTTCTGAATAAAGATGG CAACACAATTTTTTCTCCATTTTCAGTTCTTACCTGGGAACCTAATTCCCCAGAAGCTAAAAAACTAGACATTAGTTGTTTTGGTTGCTT TGTTGGAATGGAATTTAAATTTAAATGAAAGGAAAAATATATCCCTGGTAGTTTTGTGTTAACCACTGATAACTGTGGAAAGAGCTAGGT CTACTGATATACAATAAACATGTGTGCATCTTGAACAATTTGAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTCCTGTTTTTTTTTTTT TTTTTTTTTTAGTTTTCCTTTTTAATGAGCTCACCCTTTAACACAAAAAAAGCAAGGTGATGTATTTTAAAAAAGGAAGTGGAAATAAAA AAATCTCAAAGCTATTTGAGTTCTCGTCTGTCCCTAGCAGTCTTTCTTCAGCTCACTTGGCTCTCTAGATCCACTGTGGTTGGCAGTATG ACCAGAATCATGGAATTTGCTAGAACTGTGGAAGCTTCTACTCCTGCAGTAAGCACAGATCGCACTGCCTCAATAACTTGGTATTGAGCA CGTATTTTGCAAAAGCTACTTTTCCTAGTTTTCAGTATTACTTTCATGTTTTAAAAATCCCTTTAATTTCTTGCTTGAAAATCCCATGAA CATTAAAGAGCCAGAAATATTTTCCTTTGTTATGTACGGATATATATATATATAGTCTTCCAAGATAGAAGTTTACTTTTTCCTCTTCTG GTTTTGGAAAATTTCCAGATAAGACATGTCACCATTAATTCTCAACGACTGCTCTATTTTGTTGTACGGTAATAGTTATCACCTTCTAAA TTACTATGTAATTTATTCACTTATTATGTTTATTGTCTTGTATCCTTTCTCTGGAGTGTAAGCACAATGAAGACAGGAATTTTGTATATT TTTAACCAATGCAACATACTCTCAGCACCTAAAATAGTGCCGGGAACATAGTAAGGGCTCAGTAAATACTTGTTGAATAAACTCAGTCTC >In-frame_STRN3_ENST00000355683_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_1353nt AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTT CGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGG ATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGG AACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAG AAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAA CGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACAT CCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAAC TCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCG AGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCAC AGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTG >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000250457_chr14_34400421_-_2502nt GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC ACTGGGAGGTGGAACGGGCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCA ACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAG AGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGC CCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTA GGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGTTCCTGAATTCTCTTA AATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCTGTCTTGTGTGTGGTA CTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCAGAAATTCCTGCAGAC ATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGGAATGAACCTTACTTG CACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAGAGGCATCACGGAAGC CTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTGGGGTTTCTGGAGAATTATC ACAACCTAATGACATTAATACCTCTAGAAAGGGCTGCTGTCATAGTGAACAATTTATAAGTGTCCCATGGGGCAGACACTCCTTTTTTCC CAGTCCTGCAACCTGGATTTTCTGCCTCAGCCCCATTTTGCTGAAAATAATGACTTTCTGAATAAAGATGGCAACACAATTTTTTCTCCA TTTTCAGTTCTTACCTGGGAACCTAATTCCCCAGAAGCTAAAAAACTAGACATTAGTTGTTTTGGTTGCTTTGTTGGAATGGAATTTAAA TTTAAATGAAAGGAAAAATATATCCCTGGTAGTTTTGTGTTAACCACTGATAACTGTGGAAAGAGCTAGGTCTACTGATATACAATAAAC ATGTGTGCATCTTGAACAATTTGAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTCCTGTTTTTTTTTTTTTTTTTTTTTTAGTTTTCCT TTTTAATGAGCTCACCCTTTAACACAAAAAAAGCAAGGTGATGTATTTTAAAAAAGGAAGTGGAAATAAAAAAATCTCAAAGCTATTTGA GTTCTCGTCTGTCCCTAGCAGTCTTTCTTCAGCTCACTTGGCTCTCTAGATCCACTGTGGTTGGCAGTATGACCAGAATCATGGAATTTG CTAGAACTGTGGAAGCTTCTACTCCTGCAGTAAGCACAGATCGCACTGCCTCAATAACTTGGTATTGAGCACGTATTTTGCAAAAGCTAC TTTTCCTAGTTTTCAGTATTACTTTCATGTTTTAAAAATCCCTTTAATTTCTTGCTTGAAAATCCCATGAACATTAAAGAGCCAGAAATA TTTTCCTTTGTTATGTACGGATATATATATATATAGTCTTCCAAGATAGAAGTTTACTTTTTCCTCTTCTGGTTTTGGAAAATTTCCAGA TAAGACATGTCACCATTAATTCTCAACGACTGCTCTATTTTGTTGTACGGTAATAGTTATCACCTTCTAAATTACTATGTAATTTATTCA CTTATTATGTTTATTGTCTTGTATCCTTTCTCTGGAGTGTAAGCACAATGAAGACAGGAATTTTGTATATTTTTAACCAATGCAACATAC >In-frame_STRN3_ENST00000357479_chr14_31495110_-_EGLN3_ENST00000553215_chr14_34400421_-_1334nt GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC ACTGGGAGGTGGAACGGGCCGAACTGCAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCA ACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAG AGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGC CCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTA GGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGTTCCTGAATTCTCTTA AATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCTGTCTTGTGTGTGGTA CTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCAGAAATTCCTGCAGAC ATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGGAATGAACCTTACTTG CACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAGAGGCATCACGGAAGC |
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FusionGenePPI for STRN3_EGLN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STRN3 | STK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, TRAF3IP3, PPP2CB, ZRANB1, PPP2R1B, ELAVL1, SLC2A4, APC, PRPF31, LIG4, STK3, STK4, CTNNB1, FKBP15, FMNL1, KIAA1671, NACC1, PARVG, PBK, PSMD13, ZNF219, PCOLCE2, MAGEA1, SNAI3, NR1H3, ZNF444, PPP2R2C, RASSF3, COL4A5, DNAJA2, PGAM5, RUVBL2, NTRK1, XPO1, HSPE1, PON2, TCF12, MAP4K4, PKN3, DYNLL1, TMEM126A, LAMA1, PRDM14, TNFRSF1A, ZNF550, TPTE2, NHSL2, EXOC1, B4GALT4, SPINK2, ACOX2, ZNF331, YPEL1, TRIM25 | EGLN3 | OS9, HIF1A, SIAH2, EGLN1, EGLN3, EGLN2, PRPF19, ADRB2, SPRY2, LIMD1, AJUBA, WTIP, EPAS1, ATF4, IKBKB, MAGEA11, PKM, IKBKG, CHUK, MAPK1, MAPK6, MAPK7, HEXIM1, SQSTM1, REL, ABI2, NCAPH2, SERTAD1, FOXJ2, EFHC2, TTC23L, BIRC2, BIRC3, RIPK1, EPOR, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STRN3_EGLN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | EGLN3 | Q9H6Z9 | DB00126 | Vitamin C | Egl nine homolog 3 | small molecule | approved|nutraceutical |
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RelatedDiseases for STRN3_EGLN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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