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Fusion gene ID: 36589 |
FusionGeneSummary for STRIP1_CSF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRIP1_CSF1 | Fusion gene ID: 36589 | Hgene | Tgene | Gene symbol | STRIP1 | CSF1 | Gene ID | 85369 | 1435 |
| Gene name | striatin interacting protein 1 | colony stimulating factor 1 | |
| Synonyms | FAM40A|FAR11A | CSF-1|MCSF | |
| Cytomap | 1p13.3 | 1p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | striatin-interacting protein 1FAR11 factor arrest 11 homolog Afamily with sequence similarity 40, member Ahomolog of yeast FAR11 protein 1protein FAM40A | macrophage colony-stimulating factor 1colony stimulating factor 1 (macrophage)lanimostimmacrophage colony stimulating factor 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q5VSL9 | P09603 | |
| Ensembl transtripts involved in fusion gene | ENST00000369796, ENST00000369795, ENST00000369794, ENST00000461054, | ENST00000344188, ENST00000329608, ENST00000369802, ENST00000420111, ENST00000369801, ENST00000526001, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: STRIP1 [Title/Abstract] AND CSF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CSF1 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 19100238 |
| Tgene | CSF1 | GO:0008284 | positive regulation of cell proliferation | 10652277 |
| Tgene | CSF1 | GO:0010628 | positive regulation of gene expression | 1739124|10666185 |
| Tgene | CSF1 | GO:0010744 | positive regulation of macrophage derived foam cell differentiation | 17244792 |
| Tgene | CSF1 | GO:0010759 | positive regulation of macrophage chemotaxis | 19100238 |
| Tgene | CSF1 | GO:0030316 | osteoclast differentiation | 18606301 |
| Tgene | CSF1 | GO:0032270 | positive regulation of cellular protein metabolic process | 1739124 |
| Tgene | CSF1 | GO:0032946 | positive regulation of mononuclear cell proliferation | 2460758 |
| Tgene | CSF1 | GO:0045651 | positive regulation of macrophage differentiation | 2460758 |
| Tgene | CSF1 | GO:0045672 | positive regulation of osteoclast differentiation | 15304486 |
| Tgene | CSF1 | GO:1902228 | positive regulation of macrophage colony-stimulating factor signaling pathway | 19100238 |
| Tgene | CSF1 | GO:1904141 | positive regulation of microglial cell migration | 19100238 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1470-01A | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000369796 | ENST00000344188 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-3UTR | ENST00000369796 | ENST00000329608 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369796 | ENST00000369802 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369796 | ENST00000420111 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369796 | ENST00000369801 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369796 | ENST00000526001 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-3UTR | ENST00000369795 | ENST00000344188 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-3UTR | ENST00000369795 | ENST00000329608 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369795 | ENST00000369802 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369795 | ENST00000420111 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369795 | ENST00000369801 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| 5CDS-intron | ENST00000369795 | ENST00000526001 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-3UTR | ENST00000369794 | ENST00000344188 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-3UTR | ENST00000369794 | ENST00000329608 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000369794 | ENST00000369802 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000369794 | ENST00000420111 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000369794 | ENST00000369801 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000369794 | ENST00000526001 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-3UTR | ENST00000461054 | ENST00000344188 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-3UTR | ENST00000461054 | ENST00000329608 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000461054 | ENST00000369802 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000461054 | ENST00000420111 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000461054 | ENST00000369801 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
| intron-intron | ENST00000461054 | ENST00000526001 | STRIP1 | chr1 | 110585892 | + | CSF1 | chr1 | 110472203 | + |
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FusionProtFeatures for STRIP1_CSF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRIP1 | CSF1 |
| Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the cortical actin filamentdynamics and cell shape. {ECO:0000269|PubMed:21834987}. | Cytokine that plays an essential role in the regulationof survival, proliferation and differentiation of hematopoieticprecursor cells, especially mononuclear phagocytes, such asmacrophages and monocytes. Promotes the release of proinflammatorychemokines, and thereby plays an important role in innate immunityand in inflammatory processes. Plays an important role in theregulation of osteoclast proliferation and differentiation, theregulation of bone resorption, and is required for normal bonedevelopment. Required for normal male and female fertility.Promotes reorganization of the actin cytoskeleton, regulatesformation of membrane ruffles, cell adhesion and cell migration.Plays a role in lipoprotein clearance.{ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330,ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STRIP1_CSF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STRIP1_CSF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STRIP1 | STK24, MCC, CTTNBP2, CTTNBP2NL, PPP2R1A, PPP2CA, STRN, STRN3, STK26, STRN4, MOB4, PDCD10, SIKE1, STRIP2, SLMAP, FGFR1OP2, STK25, TRAF3IP3, PPP2CB, ZRANB1, EEF1B2, DDB1, POP1, COLGALT1, KATNAL2, SPTAN1, DDX1, KHSRP, NUP214, RBM4, EEF1G, STK3, STK4, ENO1, SHMT2, MOV10, NXF1, SNAI3, RASSF3, NTRK1, PRDM14, TNFRSF1A, TRPT1, ZNF550, SPINK2, LRRCC1, RGS2, PSMC5, ZNF331, PLP1, NHSL2, ZNF223, YPEL1, RAB29 | CSF1 | CSF1R, CBL, SLA2, FHL3, SGTA, NOTCH2NL, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STRIP1_CSF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STRIP1_CSF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CSF1 | C0029401 | Osteitis Deformans | 1 | CTD_human |
| Tgene | CSF1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | CSF1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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