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Fusion gene ID: 36576 |
FusionGeneSummary for STRA6_NDUFAF1 |
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Fusion gene information | Fusion gene name: STRA6_NDUFAF1 | Fusion gene ID: 36576 | Hgene | Tgene | Gene symbol | STRA6 | NDUFAF1 | Gene ID | 64220 | 51103 |
Gene name | stimulated by retinoic acid 6 | NADH:ubiquinone oxidoreductase complex assembly factor 1 | |
Synonyms | MCOPCB8|MCOPS9|PP14296 | CGI-65|CGI65|CIA30 | |
Cytomap | 15q24.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor for retinol uptake STRA6retinol binding protein 4 receptorretinol-binding protein receptor STRA6stimulated by retinoic acid 6 homologstimulated by retinoic acid gene 6 homologstimulated by retinoic acid gene 6 protein homolog | complex I intermediate-associated protein 30, mitochondrialNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1NADH dehydrogenase (ubiquinone) complex I, assembly factor 1NADH-ubiquinone oxidoreductase 1 alpha subcomplex, assembly fact | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BX79 | Q9Y375 | |
Ensembl transtripts involved in fusion gene | ENST00000395105, ENST00000423167, ENST00000323940, ENST00000449139, ENST00000416286, ENST00000574439, ENST00000535552, ENST00000563965, ENST00000574278, ENST00000432245, | ENST00000260361, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: STRA6 [Title/Abstract] AND NDUFAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STRA6 | GO:0034633 | retinol transport | 21901792 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-N5-A59F-01A | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000395105 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000423167 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000323940 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000449139 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000416286 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
5UTR-3CDS | ENST00000574439 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000535552 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000563965 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
Frame-shift | ENST00000574278 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
intron-3CDS | ENST00000432245 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
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FusionProtFeatures for STRA6_NDUFAF1 |
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Hgene | Tgene |
STRA6 | NDUFAF1 |
Chaperone protein involved in the assembly of themitochondrial NADH:ubiquinone oxidoreductase complex (complex I).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STRA6_NDUFAF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STRA6_NDUFAF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STRA6 | CLN3, NTRK1 | NDUFAF1 | MAGEA11, ATIC, ECSIT, NDUFS3, TIMMDC1, PPP2CB, FAS, LPAR1, TMEM126B, FAF2, FAM134C, NDUFA8, ACAD9, NDUFS5, NDUFA13, PNN, NDUFAF3, STK26, MRPL1, ATAD3B, NDUFB11, NDUFS1, NDUFA12, PPP1R21, NDUFAF4, PPP2R2D, NDUFS7, ASPH, IPPK, NDUFB5, C3AR1, OCLN, MARVELD2, B4GAT1, GPR21, GRPR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STRA6_NDUFAF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STRA6_NDUFAF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STRA6 | C1832661 | ANOPHTHALMIA AND PULMONARY HYPOPLASIA | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | STRA6 | C0003119 | Anophthalmos | 1 | CTD_human |
Hgene | STRA6 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | STRA6 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Hgene | STRA6 | C0024115 | Lung diseases | 1 | CTD_human |
Hgene | STRA6 | C0026010 | Microphthalmos | 1 | CTD_human |
Hgene | STRA6 | C0243050 | Cardiovascular Abnormalities | 1 | CTD_human |
Hgene | STRA6 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | STRA6 | C2677362 | Alveolar capillary dysplasia | 1 | CTD_human |
Hgene | STRA6 | C3714756 | Intellectual Disability | 1 | CTD_human |