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Fusion gene ID: 36559 |
FusionGeneSummary for STMN3_PTK6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STMN3_PTK6 | Fusion gene ID: 36559 | Hgene | Tgene | Gene symbol | STMN3 | PTK6 | Gene ID | 50861 | 5753 |
| Gene name | stathmin 3 | protein tyrosine kinase 6 | |
| Synonyms | SCLIP | BRK | |
| Cytomap | 20q13.33 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stathmin-3SCG10-like proteinstathmin-like 3 | protein-tyrosine kinase 6PTK6 protein tyrosine kinase 6breast tumor kinaseprotein-tyrosine kinase BRKtyrosine-protein kinase BRK | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NZ72 | Q13882 | |
| Ensembl transtripts involved in fusion gene | ENST00000370053, ENST00000540534, | ENST00000217185, ENST00000542869, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: STMN3 [Title/Abstract] AND PTK6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTK6 | GO:0007260 | tyrosine phosphorylation of STAT protein | 16568091|17997837 |
| Tgene | PTK6 | GO:0016477 | cell migration | 15572663 |
| Tgene | PTK6 | GO:0061099 | negative regulation of protein tyrosine kinase activity | 15539407 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A15A-01A | STMN3 | chr20 | 62288703 | - | PTK6 | chr20 | 62162280 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000370053 | ENST00000217185 | STMN3 | chr20 | 62288703 | - | PTK6 | chr20 | 62162280 | - |
| intron-3CDS | ENST00000370053 | ENST00000542869 | STMN3 | chr20 | 62288703 | - | PTK6 | chr20 | 62162280 | - |
| intron-3CDS | ENST00000540534 | ENST00000217185 | STMN3 | chr20 | 62288703 | - | PTK6 | chr20 | 62162280 | - |
| intron-3CDS | ENST00000540534 | ENST00000542869 | STMN3 | chr20 | 62288703 | - | PTK6 | chr20 | 62162280 | - |
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FusionProtFeatures for STMN3_PTK6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STMN3 | PTK6 |
| Exhibits microtubule-destabilizing activity, which isantagonized by STAT3. {ECO:0000250}. | Non-receptor tyrosine-protein kinase implicated in theregulation of a variety of signaling pathways that control thedifferentiation and maintenance of normal epithelia, as well astumor growth. Function seems to be context dependent and differdepending on cell type, as well as its intracellular localization.A number of potential nuclear and cytoplasmic substrates have beenidentified. These include the RNA-binding proteins: KHDRBS1/SAM68,KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors:STAT3 and STAT5A/B and a variety of signaling molecules:ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associatesalso with a variety of proteins that are likely upstream of PTK6in various signaling pathways, or for which PTK6 may play anadapter-like role. These proteins include ADAM15, EGFR, ERBB2,ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6promotes cellular differentiation and apoptosis. In tumors PTK6contributes to cancer progression by sensitizing cells tomitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association withEGFR, ERBB2, ERBB3 may contribute to mammary tumor development andgrowth through enhancement of EGF-induced signaling via BTK/AKTand PI3 kinase. Contributes to migration and proliferation bycontributing to EGF-mediated phosphorylation ofARHGAP35/p190RhoGAP, which promotes association withRASA1/p120RasGAP, inactivating RhoA while activating RAS. EGFstimulation resulted in phosphorylation of PNX/Paxillin by PTK6and activation of RAC1 via CRK/CrKII, thereby promoting migrationand invasion. PTK6 activates STAT3 and STAT5B to promoteproliferation. Nuclear PTK6 may be important for regulating growthin normal epithelia, while cytoplasmic PTK6 might activateoncogenic signaling pathways. Isoform 2 inhibits PTK6 phosphorylation and PTK6association with other tyrosine-phosphorylated proteins. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STMN3_PTK6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STMN3_PTK6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STMN3 | TRPC5, UBQLN1, NKX3-1, GLP1R | PTK6 | STAP2, EGFR, KHDRBS1, ERBB3, APP, ERBB2, PTK6, FGFR1, DOK1, HSP90AA1, ADAM15, REL, WASL, EXOC5, FCHO1, CCDC33, EFHC2, KHDRBS2, SOCS3, CCT3, CCT4, CCT8, TCP1, TRIM25, LINC01139, HIF1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STMN3_PTK6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PTK6 | Q13882 | DB05294 | Vandetanib | Protein-tyrosine kinase 6 | small molecule | approved |
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RelatedDiseases for STMN3_PTK6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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