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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36557

FusionGeneSummary for STMN2_FAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: STMN2_FAT1
Fusion gene ID: 36557
HgeneTgene
Gene symbol

STMN2

FAT1

Gene ID

11075

2195

Gene namestathmin 2FAT atypical cadherin 1
SynonymsSCG10|SCGN10CDHF7|CDHR8|FAT|ME5|hFat1
Cytomap

8q21.13

4q35.2

Type of geneprotein-codingprotein-coding
Descriptionstathmin-2neuron-specific growth-associated proteinneuronal growth-associated protein (silencer element)stathmin-like 2superior cervical ganglia, neural specific 10superior cervical ganglion-10 proteinprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homolog
Modification date2018052320180519
UniProtAcc

Q93045

Q14517

Ensembl transtripts involved in fusion geneENST00000220876, ENST00000518111, 
ENST00000518491, 		ENST00000441802, 
ENST00000512347, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 6 X 1=18
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STMN2 [Title/Abstract] AND FAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTMN2

GO:0007026

negative regulation of microtubule depolymerization

18452648

HgeneSTMN2

GO:0010976

positive regulation of neuron projection development

18452648|21215777

HgeneSTMN2

GO:0010977

negative regulation of neuron projection development

18452648

HgeneSTMN2

GO:0031115

negative regulation of microtubule polymerization

18452648|21215777

HgeneSTMN2

GO:0031117

positive regulation of microtubule depolymerization

18452648

HgeneSTMN2

GO:1990090

cellular response to nerve growth factor stimulus

21215777


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF963877STMN2chr8

80567176

-FAT1chr4

187628005

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000220876ENST00000441802STMN2chr8

80567176

-FAT1chr4

187628005

+
5CDS-intronENST00000220876ENST00000512347STMN2chr8

80567176

-FAT1chr4

187628005

+
In-frameENST00000518111ENST00000441802STMN2chr8

80567176

-FAT1chr4

187628005

+
5CDS-intronENST00000518111ENST00000512347STMN2chr8

80567176

-FAT1chr4

187628005

+
In-frameENST00000518491ENST00000441802STMN2chr8

80567176

-FAT1chr4

187628005

+
5CDS-intronENST00000518491ENST00000512347STMN2chr8

80567176

-FAT1chr4

187628005

+

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FusionProtFeatures for STMN2_FAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STMN2

Q93045

FAT1

Q14517

Regulator of microtubule stability. When phosphorylatedby MAPK8, stabilizes microtubules and consequently controlsneurite length in cortical neurons. In the developing brain,negatively regulates the rate of exit from multipolar stage andretards radial migration from the ventricular zone (Bysimilarity). {ECO:0000250}. Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271035_1139-704589DomainCadherin 9
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271140_1245-704589DomainCadherin 10
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271246_1357-704589DomainCadherin 11
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271359_1456-704589DomainCadherin 12
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271457_1562-704589DomainCadherin 13
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027150_257-704589DomainCadherin 2
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271563_1667-704589DomainCadherin 14
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271668_1765-704589DomainCadherin 15
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271766_1879-704589DomainCadherin 16
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271880_1979-704589DomainCadherin 17
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0271980_2081-704589DomainCadherin 18
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272082_2182-704589DomainCadherin 19
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272183_2283-704589DomainCadherin 20
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272284_2390-704589DomainCadherin 21
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272391_2492-704589DomainCadherin 22
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272493_2596-704589DomainCadherin 23
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272597_2703-704589DomainCadherin 24
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272704_2809-704589DomainCadherin 25
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272810_2918-704589DomainCadherin 26
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0272919_3023-704589DomainCadherin 27
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273024_3125-704589DomainCadherin 28
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273126_3230-704589DomainCadherin 29
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273231_3335-704589DomainCadherin 30
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273336_3440-704589DomainCadherin 31
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273441_3545-704589DomainCadherin 32
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273546_3647-704589DomainCadherin 33
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-02735_149-704589DomainCadherin 1
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027368_463-704589DomainCadherin 3
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273790_3827-704589DomainEGF-like 1
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0273829_4009-704589DomainLaminin G-like
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274013_4050-704589DomainEGF-like 2
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274052_4088-704589DomainEGF-like 3
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274089_4125-704589DomainEGF-like 4
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274127_4163-704589DomainEGF-like 5%3B calcium-binding
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027464_569-704589DomainCadherin 4
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027570_673-704589DomainCadherin 5
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027718_822-704589DomainCadherin 6
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027823_927-704589DomainCadherin 7
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-027928_1034-704589DomainCadherin 8
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274204_4214-704589MotifNuclear localization signal
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274378_4382-704589MotifPTB-like motif
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-02722_4181-704589Topological domainExtracellular
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274203_4588-704589Topological domainCytoplasmic
TgeneFAT1chr8:80567176chr4:187628005ENST00000441802-0274182_4202-704589TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STMN2_FAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STMN2_ENST00000220876_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0aa

>In-frame_STMN2_ENST00000518111_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0aa

>In-frame_STMN2_ENST00000518491_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STMN2_ENST00000220876_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt

>In-frame_STMN2_ENST00000518111_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt

>In-frame_STMN2_ENST00000518491_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_STMN2_ENST00000220876_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt

>In-frame_STMN2_ENST00000518111_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt

>In-frame_STMN2_ENST00000518491_chr8_80567176_-_FAT1_ENST00000441802_chr4_187628005_+_0nt


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FusionGenePPI for STMN2_FAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STMN2_FAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STMN2_FAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFAT1C0009404Colorectal Neoplasms1CTD_human
TgeneFAT1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneFAT1C0017636Glioblastoma1CTD_human
TgeneFAT1C0018671Head and Neck Neoplasms1CTD_human
TgeneFAT1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFAT1C0036095Salivary Gland Neoplasms1CTD_human
TgeneFAT1C0279626Squamous cell carcinoma of esophagus1CTD_human