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Fusion gene ID: 36555 |
FusionGeneSummary for STMN1_STARD7 |
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Fusion gene information | Fusion gene name: STMN1_STARD7 | Fusion gene ID: 36555 | Hgene | Tgene | Gene symbol | STMN1 | STARD7 | Gene ID | 3925 | 56910 |
Gene name | stathmin 1 | StAR related lipid transfer domain containing 7 | |
Synonyms | C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN | GTT1 | |
Cytomap | 1p36.11 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215 | stAR-related lipid transfer protein 7, mitochondrialSTART domain containing 7START domain-containing protein 7StAR-related lipid transfer (START) domain containing 7gestational trophoblastic tumor protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P16949 | Q9NQZ5 | |
Ensembl transtripts involved in fusion gene | ENST00000426559, ENST00000455785, ENST00000399728, ENST00000465604, ENST00000357865, ENST00000374291, | ENST00000337288, ENST00000462501, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 6 X 2=72 |
# samples | 3 | 6 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STMN1 [Title/Abstract] AND STARD7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STMN1 | GO:0007019 | microtubule depolymerization | 9880330 |
Hgene | STMN1 | GO:0007052 | mitotic spindle organization | 9271428 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ946944 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000426559 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000426559 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-5UTR | ENST00000455785 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000455785 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-5UTR | ENST00000399728 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000399728 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-5UTR | ENST00000465604 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000465604 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-5UTR | ENST00000357865 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000357865 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-5UTR | ENST00000374291 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
intron-intron | ENST00000374291 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
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FusionProtFeatures for STMN1_STARD7 |
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Hgene | Tgene |
STMN1 | STARD7 |
Involved in the regulation of the microtubule (MT)filament system by destabilizing microtubules. Prevents assemblyand promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.Involved in the control of the learned and innate fear (Bysimilarity). {ECO:0000250}. | May play a protective role in mucosal tissues bypreventing exaggerated allergic responses.{ECO:0000250|UniProtKB:Q8R1R3}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STMN1_STARD7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STMN1_STARD7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STMN1_STARD7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STMN1_STARD7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STMN1 | C0011570 | Mental Depression | 3 | PSYGENET |
Hgene | STMN1 | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | STMN1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | STMN1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | STMN1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | STMN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | STMN1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |