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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36539

FusionGeneSummary for STK3_PAQR3

check button Fusion gene summary
Fusion gene informationFusion gene name: STK3_PAQR3
Fusion gene ID: 36539
HgeneTgene
Gene symbol

STK3

PAQR3

Gene ID

8428

152559

Gene nameserine/threonine kinase 24progestin and adipoQ receptor family member 3
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3RKTG
Cytomap

13q32.2

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3progestin and adipoQ receptor family member 3Raf kinase trapping to Golgiprogestin and adipoQ receptor family member III
Modification date2018052320180520
UniProtAcc

Q13188

Q6TCH7

Ensembl transtripts involved in fusion geneENST00000419617, ENST00000523601, 
ENST00000521768, 
ENST00000295462, 
ENST00000512733, ENST00000515541, 
ENST00000380645, 
Fusion gene scores* DoF score15 X 8 X 8=9603 X 3 X 3=27
# samples 133
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STK3 [Title/Abstract] AND PAQR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK3

GO:0006468

protein phosphorylation

19604147

HgeneSTK3

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK3

GO:0046777

protein autophosphorylation

17046825|17657516

TgenePAQR3

GO:0001933

negative regulation of protein phosphorylation

17724343

TgenePAQR3

GO:0010977

negative regulation of neuron projection development

17724343

TgenePAQR3

GO:0033137

negative regulation of peptidyl-serine phosphorylation

17724343

TgenePAQR3

GO:0043407

negative regulation of MAP kinase activity

17724343


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-1512-01ASTK3chr8

99538970

-PAQR3chr4

79827315

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000419617ENST00000295462STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000419617ENST00000512733STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000419617ENST00000515541STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000419617ENST00000380645STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-3UTRENST00000523601ENST00000295462STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000523601ENST00000512733STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000523601ENST00000515541STK3chr8

99538970

-PAQR3chr4

79827315

-
5CDS-intronENST00000523601ENST00000380645STK3chr8

99538970

-PAQR3chr4

79827315

-
intron-3UTRENST00000521768ENST00000295462STK3chr8

99538970

-PAQR3chr4

79827315

-
intron-intronENST00000521768ENST00000512733STK3chr8

99538970

-PAQR3chr4

79827315

-
intron-intronENST00000521768ENST00000515541STK3chr8

99538970

-PAQR3chr4

79827315

-
intron-intronENST00000521768ENST00000380645STK3chr8

99538970

-PAQR3chr4

79827315

-

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FusionProtFeatures for STK3_PAQR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK3

Q13188

PAQR3

Q6TCH7

Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation.Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 andplays a role in centrosome disjunction by regulating thelocalization of NEK2 to centrosome, and its ability tophosphorylate CROCC and CEP250. In conjunction with SAV1,activates the transcriptional activity of ESR1 through themodulation of its phosphorylation. Positively regulates RAF1activation via suppression of the inhibitory phosphorylation ofRAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2.Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively withMOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10,ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043,ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395,ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796,ECO:0000269|PubMed:8816758}. Functions as a spatial regulator of RAF1 kinase bysequestrating it to the Golgi. {ECO:0000269|PubMed:18547165}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK3_PAQR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK3_PAQR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK3CNKSR1, MAP1LC3A, MAP1LC3B, RASSF5, STK4, SAV1, ATG4B, PLK1, CACYBP, RASSF2, FREM1, KHSRP, DDAH2, PHAX, QARS, MPP1, GBP2, LATS1, RASSF6, MOB4, NRD1, MOB1A, RASSF1, RAF1, MBP, MOB1B, LATS2, PTPN14, LRRK2, EIF4EBP1, TAZ, STK3, AKT1, ORM2, CPNE1, PEX19, ZC3H7A, HSPE1, SULT2A1, SLMAP, CTTNBP2NL, RASSF3, AURKB, ERLIN2, STRIP1, FGFR1OP2, KIF2C, MAP1S, PRKRIR, RAE1, RASSF4, RUNDC3B, STRN, STRN3, STRN4, TSPYL1, YWHAB, CSNK1E, NEB, MAP1B, CDK3, DST, ACACA, VAPA, FBXW11, GAD1, TRAF1, TFPT, GMCL1, FAM9B, BTRC, ADCYAP1, MRPL40, NSUN5, IFI16, FGFR1OP, CEP128, XPO1, C21orf59, CENPO, CASP3, MTMR7, KIF2B, ZNF133, VAPB, ZIM2, ZNF420, ZNF695, SKP2, KIF3B, CDK1PAQR3DDB2, BTRC, TWIST1, NFE2L2, KEAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK3_PAQR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK3_PAQR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource