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Fusion gene ID: 36535 |
FusionGeneSummary for STK3_LRRC69 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK3_LRRC69 | Fusion gene ID: 36535 | Hgene | Tgene | Gene symbol | STK3 | LRRC69 | Gene ID | 8428 | 100130742 |
| Gene name | serine/threonine kinase 24 | leucine rich repeat containing 69 | |
| Synonyms | HEL-S-95|MST3|MST3B|STE20|STK3 | - | |
| Cytomap | 13q32.2 | 8q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3 | leucine-rich repeat-containing protein 69 | |
| Modification date | 20180523 | 20180402 | |
| UniProtAcc | Q13188 | Q6ZNQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000419617, ENST00000523601, ENST00000521768, | ENST00000343709, ENST00000448384, ENST00000521519, | |
| Fusion gene scores | * DoF score | 15 X 8 X 8=960 | 2 X 2 X 2=8 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/960*10)=-2.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: STK3 [Title/Abstract] AND LRRC69 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK3 | GO:0006468 | protein phosphorylation | 19604147 |
| Hgene | STK3 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Hgene | STK3 | GO:0046777 | protein autophosphorylation | 17046825|17657516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-MA-AA43-01A | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| TCGA | LD | CESC | TCGA-MA-AA43-01A | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000419617 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| In-frame | ENST00000419617 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| 5CDS-intron | ENST00000419617 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| Frame-shift | ENST00000523601 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| Frame-shift | ENST00000523601 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| 5CDS-intron | ENST00000523601 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| intron-3CDS | ENST00000521768 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| intron-3CDS | ENST00000521768 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| intron-intron | ENST00000521768 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92212841 | + |
| Frame-shift | ENST00000419617 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000419617 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000419617 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000523601 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000523601 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000523601 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| intron-3CDS | ENST00000521768 | ENST00000343709 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| intron-3CDS | ENST00000521768 | ENST00000448384 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
| intron-intron | ENST00000521768 | ENST00000521519 | STK3 | chr8 | 99538970 | - | LRRC69 | chr8 | 92231118 | + |
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FusionProtFeatures for STK3_LRRC69 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK3 | LRRC69 |
| Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation.Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 andplays a role in centrosome disjunction by regulating thelocalization of NEK2 to centrosome, and its ability tophosphorylate CROCC and CEP250. In conjunction with SAV1,activates the transcriptional activity of ESR1 through themodulation of its phosphorylation. Positively regulates RAF1activation via suppression of the inhibitory phosphorylation ofRAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2.Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively withMOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10,ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043,ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395,ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796,ECO:0000269|PubMed:8816758}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 287_328 | 439 | 492 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 308_314 | 439 | 492 | Compositional bias | Note=Poly-Glu |
| Hgene | STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 370_375 | 439 | 492 | Compositional bias | Note=Poly-Glu |
| Hgene | STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 27_278 | 439 | 492 | Domain | Protein kinase |
| Hgene | STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 33_41 | 439 | 492 | Nucleotide binding | ATP |
| Tgene | >LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 108_129 | 95 | 192 | Repeat | Note=LRR 4 |
| Tgene | >LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 131_153 | 95 | 192 | Repeat | Note=LRR 5 |
| Tgene | >LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 154_175 | 95 | 192 | Repeat | Note=LRR 6 |
| Tgene | >LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 177_199 | 95 | 192 | Repeat | Note=LRR 7 |
| Tgene | >LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 200_222 | 95 | 192 | Repeat | Note=LRR 8 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 442_475 | 439 | 492 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STK3 | chr8:99538970 | chr8:92212841 | ENST00000419617 | - | 10 | 11 | 437_484 | 439 | 492 | Domain | SARAH |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 38_60 | 95 | 192 | Repeat | Note=LRR 1 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 61_82 | 95 | 192 | Repeat | Note=LRR 2 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000343709 | + | 1 | 4 | 84_105 | 95 | 192 | Repeat | Note=LRR 3 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 108_129 | 251 | 348 | Repeat | Note=LRR 4 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 131_153 | 251 | 348 | Repeat | Note=LRR 5 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 154_175 | 251 | 348 | Repeat | Note=LRR 6 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 177_199 | 251 | 348 | Repeat | Note=LRR 7 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 200_222 | 251 | 348 | Repeat | Note=LRR 8 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 38_60 | 251 | 348 | Repeat | Note=LRR 1 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 61_82 | 251 | 348 | Repeat | Note=LRR 2 |
| Tgene | LRRC69 | chr8:99538970 | chr8:92212841 | ENST00000448384 | + | 5 | 8 | 84_105 | 251 | 348 | Repeat | Note=LRR 3 |
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FusionGeneSequence for STK3_LRRC69 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000343709_chr8_92212841_+_536aa MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT QLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFEITSRFVMNQL >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92212841_+_536aa MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT QLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFEITSRFVMNQL >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92231118_+_476aa MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT QLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFDWKISKNLKLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000343709_chr8_92212841_+_1608nt ATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAGCTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTA GAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAAGCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTT GAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATAATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTT AAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGCGCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAA GATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGA AATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACT GTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACT TCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACA TTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACA CAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAA AGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGT GTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCC GACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGA CCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATG TCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAAGATGGAGACTTTGACTTTGAAATAACATCAAGATTTGTAATGAATCAGCTA GCAGAAAATAACCCTTTCCTAATGGATGACATAGAACGGTACCCACAAGTCAGGAGCATGATCTCTCAGGGAAAAACATGTGCAATATGT GGACAGTACTTTATAACCGTATGGCTGGAATGTGTTCGATTTGTTCCTCCACCAAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTG >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92212841_+_1608nt ATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAGCTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTA GAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAAGCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTT GAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATAATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTT AAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGCGCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAA GATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGA AATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACT GTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACT TCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACA TTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACA CAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAA AGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGT GTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCC GACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGA CCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATG TCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAAGATGGAGACTTTGACTTTGAAATAACATCAAGATTTGTAATGAATCAGCTA GCAGAAAATAACCCTTTCCTAATGGATGACATAGAACGGTACCCACAAGTCAGGAGCATGATCTCTCAGGGAAAAACATGTGCAATATGT GGACAGTACTTTATAACCGTATGGCTGGAATGTGTTCGATTTGTTCCTCCACCAAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTG >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92231118_+_1428nt ATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAGCTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTA GAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAAGCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTT GAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATAATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTT AAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGCGCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAA GATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGACTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGA AATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCAGATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACT GTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATTCAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACT TCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGATATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACA TTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGATTTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACA CAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCTGTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAA AGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAAGAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGT GTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATGAGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCC GACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAAGAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGA CCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAGAATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATG TCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAAGATGGAGACTTTGACTTTGACTGGAAGATAAGCAAGAATCTGAAGCTGGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000343709_chr8_92212841_+_1876nt CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT ATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGAT TTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCT GTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAA GAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATG AGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAA GAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAG AATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAA GATGGAGACTTTGACTTTGAAATAACATCAAGATTTGTAATGAATCAGCTAGCAGAAAATAACCCTTTCCTAATGGATGACATAGAACGG TACCCACAAGTCAGGAGCATGATCTCTCAGGGAAAAACATGTGCAATATGTGGACAGTACTTTATAACCGTATGGCTGGAATGTGTTCGA TTTGTTCCTCCACCAAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAATGTTTTACT CAACGTGACCCTAACCTCTTTGGAATTGCTCAGGTGTAGAACAGGTGAGGTGCTCATTCATAGCCTCACTCCACTTGCCCTGTCAGCTCT >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92212841_+_1749nt CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT ATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGAT TTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCT GTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAA GAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATG AGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAA GAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAG AATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAA GATGGAGACTTTGACTTTGAAATAACATCAAGATTTGTAATGAATCAGCTAGCAGAAAATAACCCTTTCCTAATGGATGACATAGAACGG TACCCACAAGTCAGGAGCATGATCTCTCAGGGAAAAACATGTGCAATATGTGGACAGTACTTTATAACCGTATGGCTGGAATGTGTTCGA TTTGTTCCTCCACCAAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAATGTTTTACT >In-frame_STK3_ENST00000419617_chr8_99538970_-_LRRC69_ENST00000448384_chr8_92231118_+_1569nt CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT ATACATCCAATGAGGGCTATTTTTATGATTCCCACAAATCCACCACCAACATTCAGAAAGCCAGAACTTTGGTCCGATGATTTCACCGAT TTTGTTAAAAAGTGTTTGGTGAAGAATCCTGAGCAGAGAGCTACTGCAACACAACTTTTACAGCATCCTTTTATCAAGAATGCCAAACCT GTATCAATATTAAGAGACCTGATCACAGAAGCTATGGAGATCAAAGCTAAAAGACATGAGGAACAGCAACGAGAATTGGAAGAGGAAGAA GAAAATTCGGATGAAGATGAGCTGGATTCCCACACCATGGTGAAGACTAGTGTGGAGAGTGTGGGCACCATGCGGGCCACAAGCACGATG AGTGAAGGGGCCCAGACCATGATTGAACATAATAGCACGATGTTGGAATCCGACTTGGGGACCATGGTGATAAACAGTGAGGATGAGGAA GAAGAAGATGGAACTATGAAAAGAAATGCAACCTCACCACAAGTACAAAGACCATCTTTCATGGACTACTTTGATAAGCAAGACTTCAAG AATAAGAGTCACGAAAACTGTAATCAGAACATGCATGAACCCTTCCCTATGTCCAAAAACGTTTTTCCTGATAACTGGAAAGTTCCTCAA GATGGAGACTTTGACTTTGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAATGTTTTACT |
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FusionGenePPI for STK3_LRRC69 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STK3 | CNKSR1, MAP1LC3A, MAP1LC3B, RASSF5, STK4, SAV1, ATG4B, PLK1, CACYBP, RASSF2, FREM1, KHSRP, DDAH2, PHAX, QARS, MPP1, GBP2, LATS1, RASSF6, MOB4, NRD1, MOB1A, RASSF1, RAF1, MBP, MOB1B, LATS2, PTPN14, LRRK2, EIF4EBP1, TAZ, STK3, AKT1, ORM2, CPNE1, PEX19, ZC3H7A, HSPE1, SULT2A1, SLMAP, CTTNBP2NL, RASSF3, AURKB, ERLIN2, STRIP1, FGFR1OP2, KIF2C, MAP1S, PRKRIR, RAE1, RASSF4, RUNDC3B, STRN, STRN3, STRN4, TSPYL1, YWHAB, CSNK1E, NEB, MAP1B, CDK3, DST, ACACA, VAPA, FBXW11, GAD1, TRAF1, TFPT, GMCL1, FAM9B, BTRC, ADCYAP1, MRPL40, NSUN5, IFI16, FGFR1OP, CEP128, XPO1, C21orf59, CENPO, CASP3, MTMR7, KIF2B, ZNF133, VAPB, ZIM2, ZNF420, ZNF695, SKP2, KIF3B, CDK1 | LRRC69 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK3_LRRC69 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK3_LRRC69 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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