![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 36511 |
FusionGeneSummary for STK33_CHRNB4 |
![]() |
Fusion gene information | Fusion gene name: STK33_CHRNB4 | Fusion gene ID: 36511 | Hgene | Tgene | Gene symbol | STK33 | CHRNB4 | Gene ID | 65975 | 1143 |
Gene name | serine/threonine kinase 33 | cholinergic receptor nicotinic beta 4 subunit | |
Synonyms | - | - | |
Cytomap | 11p15.4 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 33 | neuronal acetylcholine receptor subunit beta-4acetylcholine receptor, nicotinic, beta 4 (neuronal)cholinergic receptor, nicotinic, beta 4 (neuronal)cholinergic receptor, nicotinic, beta polypeptide 4neuronal nicotinic receptor beta 4 subunit | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BYT3 | P30926 | |
Ensembl transtripts involved in fusion gene | ENST00000396673, ENST00000396672, ENST00000315204, ENST00000358872, ENST00000534493, ENST00000473980, ENST00000447869, | ENST00000261751, ENST00000412074, ENST00000560511, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: STK33 [Title/Abstract] AND CHRNB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CHRNB4 | GO:0007165 | signal transduction | 8906617 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | MESO | TCGA-TS-A7OZ-01A | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000396673 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000396673 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000396673 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000396672 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000396672 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000396672 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000315204 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000315204 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000315204 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000358872 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000358872 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000358872 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000534493 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000534493 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000534493 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
intron-intron | ENST00000473980 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
intron-intron | ENST00000473980 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
intron-5UTR | ENST00000473980 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000447869 | ENST00000261751 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-intron | ENST00000447869 | ENST00000412074 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
5CDS-5UTR | ENST00000447869 | ENST00000560511 | STK33 | chr11 | 8462225 | - | CHRNB4 | chr15 | 79000447 | - |
Top |
FusionProtFeatures for STK33_CHRNB4 |
![]() |
Hgene | Tgene |
STK33 | CHRNB4 |
Serine/threonine protein kinase which phosphorylatesVIME. May play a specific role in the dynamic behavior of theintermediate filament cytoskeleton by phosphorylation of VIME (Bysimilarity). Not essential for the survival of KRAS-dependent AMLcell lines. {ECO:0000250, ECO:0000269|PubMed:21742770}. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for STK33_CHRNB4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for STK33_CHRNB4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STK33 | HSP90AB1, HSP90AA1, CDC37, HERC2, BAG2, USP5, USP15, APP, GLYCTK | CHRNB4 | TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for STK33_CHRNB4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CHRNB4 | P30926 | DB00184 | Nicotine | Neuronal acetylcholine receptor subunit beta-4 | small molecule | approved |
Tgene | CHRNB4 | P30926 | DB00514 | Dextromethorphan | Neuronal acetylcholine receptor subunit beta-4 | small molecule | approved |
Tgene | CHRNB4 | P30926 | DB00674 | Galantamine | Neuronal acetylcholine receptor subunit beta-4 | small molecule | approved |
Tgene | CHRNB4 | P30926 | DB00898 | Ethanol | Neuronal acetylcholine receptor subunit beta-4 | small molecule | approved |
Tgene | CHRNB4 | P30926 | DB01227 | Levomethadyl Acetate | Neuronal acetylcholine receptor subunit beta-4 | small molecule | approved|investigational |
Top |
RelatedDiseases for STK33_CHRNB4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHRNB4 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Tgene | CHRNB4 | C0036572 | Seizures | 2 | CTD_human |
Tgene | CHRNB4 | C0600427 | Cocaine Dependence | 2 | PSYGENET |
Tgene | CHRNB4 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | CHRNB4 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |