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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36511

FusionGeneSummary for STK33_CHRNB4

check button Fusion gene summary
Fusion gene informationFusion gene name: STK33_CHRNB4
Fusion gene ID: 36511
HgeneTgene
Gene symbol

STK33

CHRNB4

Gene ID

65975

1143

Gene nameserine/threonine kinase 33cholinergic receptor nicotinic beta 4 subunit
Synonyms--
Cytomap

11p15.4

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 33neuronal acetylcholine receptor subunit beta-4acetylcholine receptor, nicotinic, beta 4 (neuronal)cholinergic receptor, nicotinic, beta 4 (neuronal)cholinergic receptor, nicotinic, beta polypeptide 4neuronal nicotinic receptor beta 4 subunit
Modification date2018052320180523
UniProtAcc

Q9BYT3

P30926

Ensembl transtripts involved in fusion geneENST00000396673, ENST00000396672, 
ENST00000315204, ENST00000358872, 
ENST00000534493, ENST00000473980, 
ENST00000447869, 
ENST00000261751, 
ENST00000412074, ENST00000560511, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: STK33 [Title/Abstract] AND CHRNB4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHRNB4

GO:0007165

signal transduction

8906617


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDMESOTCGA-TS-A7OZ-01ASTK33chr11

8462225

-CHRNB4chr15

79000447

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396673ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000396673ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000396673ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000396672ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000396672ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000396672ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000315204ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000315204ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000315204ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000358872ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000358872ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000358872ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000534493ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000534493ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000534493ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
intron-intronENST00000473980ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
intron-intronENST00000473980ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
intron-5UTRENST00000473980ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000447869ENST00000261751STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-intronENST00000447869ENST00000412074STK33chr11

8462225

-CHRNB4chr15

79000447

-
5CDS-5UTRENST00000447869ENST00000560511STK33chr11

8462225

-CHRNB4chr15

79000447

-

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FusionProtFeatures for STK33_CHRNB4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK33

Q9BYT3

CHRNB4

P30926

Serine/threonine protein kinase which phosphorylatesVIME. May play a specific role in the dynamic behavior of theintermediate filament cytoskeleton by phosphorylation of VIME (Bysimilarity). Not essential for the survival of KRAS-dependent AMLcell lines. {ECO:0000250, ECO:0000269|PubMed:21742770}. After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK33_CHRNB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK33_CHRNB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK33HSP90AB1, HSP90AA1, CDC37, HERC2, BAG2, USP5, USP15, APP, GLYCTKCHRNB4TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK33_CHRNB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCHRNB4P30926DB00184NicotineNeuronal acetylcholine receptor subunit beta-4small moleculeapproved
TgeneCHRNB4P30926DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4small moleculeapproved
TgeneCHRNB4P30926DB00674GalantamineNeuronal acetylcholine receptor subunit beta-4small moleculeapproved
TgeneCHRNB4P30926DB00898EthanolNeuronal acetylcholine receptor subunit beta-4small moleculeapproved
TgeneCHRNB4P30926DB01227Levomethadyl AcetateNeuronal acetylcholine receptor subunit beta-4small moleculeapproved|investigational

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RelatedDiseases for STK33_CHRNB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHRNB4C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneCHRNB4C0036572Seizures2CTD_human
TgeneCHRNB4C0600427Cocaine Dependence2PSYGENET
TgeneCHRNB4C0024121Lung Neoplasms1CTD_human
TgeneCHRNB4C0038587Substance Withdrawal Syndrome1CTD_human