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Fusion gene ID: 36509 |
FusionGeneSummary for STK32B_SMIM14 |
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Fusion gene information | Fusion gene name: STK32B_SMIM14 | Fusion gene ID: 36509 | Hgene | Tgene | Gene symbol | STK32B | SMIM14 | Gene ID | 55351 | 201895 |
Gene name | serine/threonine kinase 32B | small integral membrane protein 14 | |
Synonyms | HSA250839|STK32|STKG6|YANK2 | C4orf34 | |
Cytomap | 4p16.2 | 4p14 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 32Bgene for serine/threonine protein kinaseyet another novel kinase 2 | small integral membrane protein 14 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9NY57 | Q96QK8 | |
Ensembl transtripts involved in fusion gene | ENST00000282908, ENST00000512636, ENST00000510398, ENST00000508728, | ENST00000295958, ENST00000511809, ENST00000510628, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 2 X 4=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STK32B [Title/Abstract] AND SMIM14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-22-A5C4-01A | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000282908 | ENST00000295958 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5CDS-5UTR | ENST00000282908 | ENST00000511809 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5CDS-intron | ENST00000282908 | ENST00000510628 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-5UTR | ENST00000512636 | ENST00000295958 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-5UTR | ENST00000512636 | ENST00000511809 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-intron | ENST00000512636 | ENST00000510628 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-5UTR | ENST00000510398 | ENST00000295958 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-5UTR | ENST00000510398 | ENST00000511809 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
5UTR-intron | ENST00000510398 | ENST00000510628 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
intron-5UTR | ENST00000508728 | ENST00000295958 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
intron-5UTR | ENST00000508728 | ENST00000511809 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
intron-intron | ENST00000508728 | ENST00000510628 | STK32B | chr4 | 5141687 | + | SMIM14 | chr4 | 39606800 | - |
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FusionProtFeatures for STK32B_SMIM14 |
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Hgene | Tgene |
STK32B | SMIM14 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STK32B_SMIM14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STK32B_SMIM14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STK32B | HSP90AA1 | SMIM14 | ELAVL1, LSM4, FATE1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK32B_SMIM14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK32B_SMIM14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |