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Fusion gene ID: 36507 |
FusionGeneSummary for STK32B_GINS1 |
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Fusion gene information | Fusion gene name: STK32B_GINS1 | Fusion gene ID: 36507 | Hgene | Tgene | Gene symbol | STK32B | GINS1 | Gene ID | 55351 | 9837 |
Gene name | serine/threonine kinase 32B | GINS complex subunit 1 | |
Synonyms | HSA250839|STK32|STKG6|YANK2 | IMD55|PSF1 | |
Cytomap | 4p16.2 | 20p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 32Bgene for serine/threonine protein kinaseyet another novel kinase 2 | DNA replication complex GINS protein PSF1GINS complex subunit 1 (Psf1 homolog)partner of sld five-1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NY57 | Q14691 | |
Ensembl transtripts involved in fusion gene | ENST00000282908, ENST00000512636, ENST00000510398, ENST00000508728, | ENST00000262460, ENST00000429262, ENST00000484893, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 3=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STK32B [Title/Abstract] AND GINS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-ER-A19H-06A | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000282908 | ENST00000262460 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
Frame-shift | ENST00000282908 | ENST00000429262 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5CDS-3UTR | ENST00000282908 | ENST00000484893 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3CDS | ENST00000512636 | ENST00000262460 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3CDS | ENST00000512636 | ENST00000429262 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3UTR | ENST00000512636 | ENST00000484893 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3CDS | ENST00000510398 | ENST00000262460 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3CDS | ENST00000510398 | ENST00000429262 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
5UTR-3UTR | ENST00000510398 | ENST00000484893 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
intron-3CDS | ENST00000508728 | ENST00000262460 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
intron-3CDS | ENST00000508728 | ENST00000429262 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
intron-3UTR | ENST00000508728 | ENST00000484893 | STK32B | chr4 | 5141687 | + | GINS1 | chr20 | 25397740 | + |
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FusionProtFeatures for STK32B_GINS1 |
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Hgene | Tgene |
STK32B | GINS1 |
The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.{ECO:0000269|PubMed:17417653}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STK32B_GINS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STK32B_GINS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STK32B | HSP90AA1 | GINS1 | GINS4, GINS3, GINS2, MRE11A, TOPBP1, TIPIN, CSNK1G2, GTF2E2, CCDC84, MCM7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK32B_GINS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK32B_GINS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |