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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36500

FusionGeneSummary for STK24_RNF4

check button Fusion gene summary
Fusion gene informationFusion gene name: STK24_RNF4
Fusion gene ID: 36500
HgeneTgene
Gene symbol

STK24

RNF4

Gene ID

8428

6047

Gene nameserine/threonine kinase 24ring finger protein 4
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3RES4-26|SLX5|SNURF
Cytomap

13q32.2

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3E3 ubiquitin-protein ligase RNF4E3 ubiquitin ligase RNF4RING-type E3 ubiquitin transferase RNF4small nuclear RING finger protein
Modification date2018052320180523
UniProtAcc

Q9Y6E0

P78317

Ensembl transtripts involved in fusion geneENST00000397517, ENST00000539966, 
ENST00000481288, ENST00000376547, 
ENST00000314289, ENST00000541204, 
ENST00000509258, ENST00000511843, 
ENST00000511859, ENST00000506706, 
ENST00000511600, 
Fusion gene scores* DoF score11 X 5 X 9=4952 X 2 X 2=8
# samples 182
** MAII scorelog2(18/495*10)=-1.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: STK24 [Title/Abstract] AND RNF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK24

GO:0006468

protein phosphorylation

19604147

HgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516

TgeneRNF4

GO:0045944

positive regulation of transcription by RNA polymerase II

12885770

TgeneRNF4

GO:0046685

response to arsenic-containing substance

20943951


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU125424STK24chr13

99116061

-RNF4chr4

2470870

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000397517ENST00000314289STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000397517ENST00000541204STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000397517ENST00000509258STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000397517ENST00000511843STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000397517ENST00000511859STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000397517ENST00000506706STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000397517ENST00000511600STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000539966ENST00000314289STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000539966ENST00000541204STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000539966ENST00000509258STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000539966ENST00000511843STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000539966ENST00000511859STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000539966ENST00000506706STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000539966ENST00000511600STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000481288ENST00000314289STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000481288ENST00000541204STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000481288ENST00000509258STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000481288ENST00000511843STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000481288ENST00000511859STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000481288ENST00000506706STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000481288ENST00000511600STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000376547ENST00000314289STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000376547ENST00000541204STK24chr13

99116061

-RNF4chr4

2470870

+
intron-5UTRENST00000376547ENST00000509258STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000376547ENST00000511843STK24chr13

99116061

-RNF4chr4

2470870

+
intron-3UTRENST00000376547ENST00000511859STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000376547ENST00000506706STK24chr13

99116061

-RNF4chr4

2470870

+
intron-intronENST00000376547ENST00000511600STK24chr13

99116061

-RNF4chr4

2470870

+

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FusionProtFeatures for STK24_RNF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK24

Q9Y6E0

RNF4

P78317

Serine/threonine-protein kinase that acts on both serineand threonine residues and promotes apoptosis in response tostress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) duringoxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nucleartranslocation of AIFM1 and ENDOG and the DNase activity associatedwith ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates itskinase activity. In association with STK26 negatively regulatesGolgi reorientation in polarized cell migration upon RHOactivation (PubMed:27807006). Regulates also cellular migrationwith alteration of PTPN12 activity and PXN phosphorylation:phosphorylates PTPN12 and inhibits its activity and may regulatePXN phosphorylation through PTPN12. May act as a key regulator ofaxon regeneration in the optic nerve and radial nerve.{ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825,ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762,ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. E3 ubiquitin-protein ligase which binds polysumoylatedchains covalently attached to proteins and mediates 'Lys-6'-,'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination ofthose substrates and their subsequent targeting to the proteasomefor degradation. Regulates the degradation of several proteinsincluding PML and the transcriptional activator PEA3. Involved inchromosome alignment and spindle assembly, it regulates thekinetochore CENPH-CENPI-CENPK complex by targeting polysumoylatedCENPI to proteasomal degradation. Regulates the cellular responsesto hypoxia and heat shock through degradation of respectivelyEPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomesand have a more direct role in the regulation of transcription forinstance enhancing basal transcription and steroid receptor-mediated transcriptional activation. {ECO:0000269|PubMed:12885770,ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308,ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20943951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK24_RNF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK24_RNF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK24_RNF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK24_RNF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource