|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 36475 |
FusionGeneSummary for STK10_UBTD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK10_UBTD2 | Fusion gene ID: 36475 | Hgene | Tgene | Gene symbol | STK10 | UBTD2 | Gene ID | 6793 | 92181 |
| Gene name | serine/threonine kinase 10 | ubiquitin domain containing 2 | |
| Synonyms | LOK|PRO2729 | DCUBP | |
| Cytomap | 5q35.1 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 10lymphocyte-oriented kinase | ubiquitin domain-containing protein 2ubiquitin-like protein SB72 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O94804 | Q8WUN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000176763, ENST00000517775, | ENST00000393792, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 2=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STK10 [Title/Abstract] AND UBTD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-2H-A9GJ-01A | STK10 | chr5 | 171544485 | - | UBTD2 | chr5 | 171661362 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000176763 | ENST00000393792 | STK10 | chr5 | 171544485 | - | UBTD2 | chr5 | 171661362 | - |
| intron-3CDS | ENST00000517775 | ENST00000393792 | STK10 | chr5 | 171544485 | - | UBTD2 | chr5 | 171661362 | - |
Top |
FusionProtFeatures for STK10_UBTD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK10 | UBTD2 |
| Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STK10 | chr5:171544485 | chr5:171661362 | ENST00000176763 | - | 4 | 19 | 42_50 | 173 | 969 | Nucleotide binding | ATP |
| Tgene | >UBTD2 | chr5:171544485 | chr5:171661362 | ENST00000393792 | - | 0 | 3 | 152_227 | 23 | 235 | Domain | Ubiquitin-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STK10 | chr5:171544485 | chr5:171661362 | ENST00000176763 | - | 4 | 19 | 573_947 | 173 | 969 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STK10 | chr5:171544485 | chr5:171661362 | ENST00000176763 | - | 4 | 19 | 750_884 | 173 | 969 | Compositional bias | Note=Gln-rich |
| Hgene | >STK10 | chr5:171544485 | chr5:171661362 | ENST00000176763 | - | 4 | 19 | 36_294 | 173 | 969 | Domain | Protein kinase |
| Hgene | >STK10 | chr5:171544485 | chr5:171661362 | ENST00000176763 | - | 4 | 19 | 175_224 | 173 | 969 | Region | Note=Activation segment |
Top |
FusionGeneSequence for STK10_UBTD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STK10_ENST00000176763_chr5_171544485_-_UBTD2_ENST00000393792_chr5_171661362_-_385aa MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLVALGRNQ PLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPV YCLAPPINMIEEKSDIETLDIPEPPPNSGYECQLRLRLSTGKDLKLVVRSTDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEEL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STK10_ENST00000176763_chr5_171544485_-_UBTD2_ENST00000393792_chr5_171661362_-_1155nt ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCT TTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCAC CCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCC ATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGC AAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGTTGCTCTAGGTCGTAACCAG CCTTTGAAAAAGGAGAAACCAAAATGGAAAAGCGATTATCCTATGACAGATGGACAACTACGCAGCAAGAGGGATGAATTTTGGGATACA GCACCAGCTTTTGAAGGCCGGAAAGAGATTTGGGATGCCTTGAAGGCTGCTGCACATGCTTTTGAGAGCAATGATCATGAACTGGCACAA GCAATCATTGATGGTGCAAACATAACATTACCACATGGTGCACTTACAGAGTGCTACGATGAACTGGGGAACAGATATCAGCTTCCAGTG TATTGCTTGGCACCGCCAATCAACATGATAGAGGAAAAGAGCGACATAGAGACTCTGGATATTCCTGAGCCACCACCCAATTCTGGATAT GAATGTCAGCTTCGTTTGCGCCTTTCCACAGGCAAAGACCTCAAGCTTGTGGTTCGCAGCACAGACACAGTATTCCACATGAAGAGACGG TTGCATGCAGCAGAGGGAGTGGAACCAGGTAGTCAGCGGTGGTTTTTTTCTGGCAGACCTCTCACTGACAAAATGAAGTTCGAAGAGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STK10_ENST00000176763_chr5_171544485_-_UBTD2_ENST00000393792_chr5_171661362_-_3689nt CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGG ACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACC GAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGTTGCTCTAGGTCGTAACCAGCCTTTGAAAAAGGAGA AACCAAAATGGAAAAGCGATTATCCTATGACAGATGGACAACTACGCAGCAAGAGGGATGAATTTTGGGATACAGCACCAGCTTTTGAAG GCCGGAAAGAGATTTGGGATGCCTTGAAGGCTGCTGCACATGCTTTTGAGAGCAATGATCATGAACTGGCACAAGCAATCATTGATGGTG CAAACATAACATTACCACATGGTGCACTTACAGAGTGCTACGATGAACTGGGGAACAGATATCAGCTTCCAGTGTATTGCTTGGCACCGC CAATCAACATGATAGAGGAAAAGAGCGACATAGAGACTCTGGATATTCCTGAGCCACCACCCAATTCTGGATATGAATGTCAGCTTCGTT TGCGCCTTTCCACAGGCAAAGACCTCAAGCTTGTGGTTCGCAGCACAGACACAGTATTCCACATGAAGAGACGGTTGCATGCAGCAGAGG GAGTGGAACCAGGTAGTCAGCGGTGGTTTTTTTCTGGCAGACCTCTCACTGACAAAATGAAGTTCGAAGAGCTGAAGATCCCAAAGGACT ATGTTGTACAGGTTATAGTGAGCCAACCTGTGCAGAACCCAACACCAGTGGAGAACTGAACTGAGCCCTGTTGGCCAGCTCCCACATCCC TCTGCTCCTTTTTATGGTTCTTGTTGTCATTTCCTACTCTGCGGCGTGAAATCTATTTCACTGCTCTAAATTCCCTATGAATGGATTTAG TTCTGAGGAATTACCAGTGAAAAATTCCATCTGTGATGGAGACCAACAAAAATAATAAAACACAAAGAGCCAGGCTTTGAGACTCATGTA ATTACAATTTCTAATTTGAAAGGCAGTTAAGAAATAGATAACCATTTATTTTAGAACACTCAACAACTATGTAATGGCTATATTTCAGTG ACTTGGACTGTAAATGAAACATTGCATCCATGAAGGACAGCACCAAGCACCTTTTTGAATACAGAATTTTTTTAGAAAAATATATCAAAT TATATAATTTCCAGAAACCATAAATAATGGATATAAAACTTAACCTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTT GGTTAATGGAAACTGAAAAGAGCAGTATTTGAGGTTGCTTCTATTCTGGTTTTTTATTCTTAGCTCAATTAATATTTAGCCATAAATGAG TAGAGACTGGCAAATTGTGCTTTAGTGTTGCTTTCCTCATCCCCACATCTTGAGCTCCTTATTTACATTCACACTAAATTTTGGTGCCTT CCAGCACATTAGTGGCAGGCACCCTTCTGGAACACTAGGCAATAATTTCATCAATACAGTCAGGTCTCTTGAGTTTCAACAGATACTCAG TTGAAAAGTCGCTGTCATCTTGCTGCATAAGTATTTTGAAAGGTCTGTATAACGAAGCCATTTTTATATCCAGGCTTAGAAGGTCACTAC TATATAGTACCTTCATTGATCTATCTATTCTGCTTGGAACTTTTCATAGCTAAGTATAACCCCCAAATGCATGGTTCCTGGGTCAGGAGA CACCAAAATCAATTATAGCTGTTCCCACTCAAGTTAATAAAGTAAATGATTTCCTCCACTTTGCATGGAGGGGTGTAAGGAAAGCCTATT TTATCTGTGCCTGGGAGAACTGTGCCTATTTTCAGTCTTTTAGAGGAAATTTCAACTCAAAATTTTTAAGTGTGAAAGATTTACTGGTGT CACATAAACATTAGCAGTGAGACCAAATAATGAAACATTGCTTTATACCTTAGTGCTTTCCAGTTCACTGTTACCTCTAGTCATGGTAGA TGACAATTTTCCTCCCTCATCTTTTGTAGCAAAGAAGCAAATTAAGAGCCTTTTGCAAGTTAGATTAGGGGACTGAAAAATCCAGGGAGA TAACCTGATTCTTCTATACTATGACTGGAGTAAAGCTGCCAAGAGTTAGGTTGAATTTGGAGCCTTTTAAAAGTTGGTTCCATAAGTGAG AAGGGGGGCTAACATGTGACCACTGTGCCCCTGAGAATCCATGAGATGGAAAAGTACAGACAAGAAGGCACTTAACGCTGTTCTCAGTTG GAAAATGTCAGCCCTCCACACCTGTTTGGATGTGAAGTGCATTATTAATTTTAATGACAAAATGAAACTGCTAATTAGTTTAAATGTAAT GTTTAAATGGTATTGAATTTCCTATTGCCTGATTAAATATATCTGTAATTGTAACATCATGTTTCTGAGAGCTTTAACTACTTCCTTATT TTTATGCAATCATTTTAAAGATTGTGGCTATATCTAATTTAAATTTGCTGATGATTGAATCTAAATTCAAGTGAAGACCACAGCATTAAT CCCAAAGGAGATTTTTTTTATGTTTAGAGGTGGAGATATTAGGGTAAATCAGTATATTGCTCCTGTCATCAAAGTTTTTGTTCATTTGTG TGCCACATCGAATAGCAGCACTTCTCAAAGTTTGTCAACTGGAAAAAAGTGTTTAAAACTGTTTTTTTCTTAAGCAGATTTGGTGATGTC ATCAATATCTATGATATCGATTGGTAAAAGGTCTTTCTTTGTTGAGGATTTGAGCTCTCTTTTTAAGAGTTTATTTTATTTTAAAGGAAC ATATGCTTTGAATAACAATTCTCTGGGCATGTTTAACTAACCTAGGTGGGAAAACCATGGTGCTGTTTAATTGTAAATAGATTGATATAA |
Top |
FusionGenePPI for STK10_UBTD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STK10 | CD81, ENO1, SHMT2, MOV10, NXF1, KIFC1, XPO1, TRIM25 | UBTD2 | UBC, UBA1, USP5, TRIM39, GALT, CST1, CST4, SMR3B, DUSP22, TMEM185A, PCDHGC3, GJB7, HOXB5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for STK10_UBTD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for STK10_UBTD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | STK10 | C1336708 | Testicular Germ Cell Tumor | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|