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Fusion gene ID: 36471 |
FusionGeneSummary for STK10_SH3PXD2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK10_SH3PXD2B | Fusion gene ID: 36471 | Hgene | Tgene | Gene symbol | STK10 | SH3PXD2B | Gene ID | 6793 | 285590 |
| Gene name | serine/threonine kinase 10 | SH3 and PX domains 2B | |
| Synonyms | LOK|PRO2729 | FAD49|FTHS|HOFI|KIAA1295|TKS4|TSK4 | |
| Cytomap | 5q35.1 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 10lymphocyte-oriented kinase | SH3 and PX domain-containing protein 2Badapter protein HOFIadaptor protein HOFIfactor for adipocyte differentiation 49tyrosine kinase substrate with four SH3 domains | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94804 | A1X283 | |
| Ensembl transtripts involved in fusion gene | ENST00000176763, ENST00000517775, | ENST00000519643, ENST00000311601, ENST00000523651, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 3=27 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STK10 [Title/Abstract] AND SH3PXD2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
| Tgene | SH3PXD2B | GO:0006801 | superoxide metabolic process | 19755710 |
| Tgene | SH3PXD2B | GO:0072657 | protein localization to membrane | 19755710 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A18T-01A | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000176763 | ENST00000519643 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| In-frame | ENST00000176763 | ENST00000311601 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| 5CDS-intron | ENST00000176763 | ENST00000523651 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| intron-3CDS | ENST00000517775 | ENST00000519643 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| intron-3CDS | ENST00000517775 | ENST00000311601 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
| intron-intron | ENST00000517775 | ENST00000523651 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
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FusionProtFeatures for STK10_SH3PXD2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK10 | SH3PXD2B |
| Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}. | Adapter protein involved in invadopodia and podosomeformation and extracellular matrix degradation. Binds matrixmetalloproteinases (ADAMs), NADPH oxidases (NOXs) andphosphoinositides. Acts as an organizer protein that allowsNOX1- or NOX3-dependent reactive oxygen species (ROS) generationand ROS localization. Plays a role in mitotic clonal expansionduring the immediate early stage of adipocyte differentiation (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12615925,ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 42_50 | 107 | 969 | Nucleotide binding | ATP |
| Tgene | >SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 729_806 | 25 | 912 | Compositional bias | Note=Pro-rich |
| Tgene | >SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 152_211 | 25 | 912 | Domain | SH3 1 |
| Tgene | >SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 221_280 | 25 | 912 | Domain | SH3 2 |
| Tgene | >SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 368_427 | 25 | 912 | Domain | SH3 3 |
| Tgene | >SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 850_911 | 25 | 912 | Domain | SH3 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 573_947 | 107 | 969 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 750_884 | 107 | 969 | Compositional bias | Note=Gln-rich |
| Hgene | >STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 36_294 | 107 | 969 | Domain | Protein kinase |
| Hgene | >STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 175_224 | 107 | 969 | Region | Note=Activation segment |
| Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | - | 0 | 13 | 5_129 | 25 | 912 | Domain | PX |
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FusionGeneSequence for STK10_SH3PXD2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000519643_chr5_171849500_-_513aa MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH PYIVKLLGAYYHDGKLWVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPI DEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESG WWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKN SGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQ >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000311601_chr5_171849500_-_994aa MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH PYIVKLLGAYYHDGKLWVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPI DEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESG WWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKN SGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQ VEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENN TGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQ LRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKS RPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRA PPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDT RGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000519643_chr5_171849500_-_1539nt ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCT TTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCAC CCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACC GAGGCCATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCC AAGCAGCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATT GATGAATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGAC CTGAATCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTG GTGGTAGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGT TGGTGGTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTG CAGCCTGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTG GAGGTCATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAAC AGTGGGGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAAC GCGGTGGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGA TCACCAAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAA GTGGAGGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGATCAT AAGAATGTTCACTTGGAGAGCCCTGTGGAAGTCCCTCTTAGAAGAATCAAGATGCGGACAGCACTTGGGAAGCACGTGGCAGCTTCCATG >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000311601_chr5_171849500_-_2982nt ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCT TTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCAC CCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACC GAGGCCATTTACCGGCGCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCC AAGCAGCGGATCATCCCCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATT GATGAATACTGTAAGGCCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGAC CTGAATCCCCCCAAAGAGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTG GTGGTAGCCAACTACCAGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGT TGGTGGTTCGTCAGCACTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTG CAGCCTGAAGAAGAGGAGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTG GAGGTCATCCAGAAAAACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAAC AGTGGGGAGCCCTTGCCCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAAC GCGGTGGGCAGGGAGAAGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGA TCACCAAAGATGAGGCAGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAA GTGGAGGAAGAGTATTACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGTGATC GAGAAAAACTTGAGTGGCTGGTGGTACATTCAGATTGAAGATAAGGAAGGGTGGGCCCCGGCCACCTTCATTGACAAGTACAAGAAGACG AGCAACGCGTCGAGACCCAACTTTCTGGCTCCCCTGCCCCACGAGGTGACCCAGCTCCGGCTGGGGGAAGCAGCAGCGCTGGAGAACAAC ACGGGCAGCGAAGCCACGGGCCCCTCCCGGCCCCTGCCTGACGCACCGCATGGTGTCATGGACTCGGGGTTGCCATGGTCTAAAGACTGG AAGGGCAGTAAGGATGTCCTGAGGAAGGCATCTTCAGACATGTCTGCGTCAGCAGGCTACGAGGAGATCTCAGACCCCGACATGGAGGAG AAGCCCAGCCTCCCTCCGCGGAAAGAATCCATCATCAAGTCGGAGGGGGAGCTGCTGGAGCGGGAGCGGGAGCGGCAGAGGACGGAGCAG CTCCGGGGCCCCACTCCCAAGCCTCCGGGCGTGATTTTGCCGATGATGCCAGCCAAACACATCCCTCCAGCCCGGGACAGCAGGAGGCCA GAGCCCAAACCTGACAAAAGCAGACTGTTCCAGCTGAAAAATGACATGGGGCTGGAGTGTGGCCACAAGGTCTTGGCCAAGGAAGTGAAG AAGCCCAACCTCCGGCCCATCTCCAAATCCAAAACTGACCTGCCAGAGGAGAAGCCAGATGCCACTCCCCAGAATCCCTTCTTGAAGTCC AGACCTCAGGTTAGGCCAAAACCAGCTCCTTCCCCCAAAACGGAGCCACCTCAGGGCGAAGACCAAGTCGACATCTGCAACCTCAGGAGT AAGCTCAGGCCTGCCAAGTCCCAAGACAAGTCCTTGTTGGATGGGGAGGGCCCCCAGGCAGTAGGGGGCCAAGACGTGGCCTTCAGCCGA AGCTTCCTCCCAGGAGAGGGGCCTGGCCGCGCCCAGGACAGGACGGGCAAACAGGATGGTCTCAGCCCAAAAGAGATTTCCTGCAGAGCC CCTCCGAGGCCAGCCAAGACCACAGATCCTGTGTCTAAGAGCGTGCCTGTTCCTCTCCAAGAGGCTCCCCAGCAGAGACCTGTGGTCCCA CCCCGCAGACCACCTCCCCCAAAGAAAACCTCTTCGTCATCCAGGCCGCTCCCAGAGGTCAGAGGTCCACAGTGTGAAGGCCACGAAAGC AGGGCAGCTCCCACCCCAGGCCGTGCTCTCCTCGTCCCTCCAAAAGCCAAACCTTTTCTCTCCAACTCTTTGGGGGGCCAGGATGACACG CGAGGCAAAGGCAGCCTGGGGCCATGGGGGACCGGCAAGATTGGAGAAAACAGGGAGAAAGCAGCTGCAGCCTCTGTCCCCAATGCCGAC GGCCTGAAGGACTCTTTGTATGTGGCCGTGGCCGACTTTGAAGGAGACAAAGACACCAGCAGCTTCCAGGAAGGGACAGTGTTTGAAGTC CGGGAGAAGAACAGCAGTGGCTGGTGGTTCTGCCAGGTCCTGAGCGGAGCCCCTTCCTGGGAAGGGTGGATTCCTTCCAACTATCTCAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000519643_chr5_171849500_-_1978nt CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATTTACCGGC GCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGGATCATCC CCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATACTGTAAGG CCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCCCCCAAAG AGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCCAACTACC AGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTCGTCAGCA CTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAAGAAGAGG AGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATCCAGAAAA ACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAGCCCTTGC CCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGCAGGGAGA AGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAGATGAGGC AGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAAGAGTATT ACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGATCATAAGAATGTTCACTTGG AGAGCCCTGTGGAAGTCCCTCTTAGAAGAATCAAGATGCGGACAGCACTTGGGAAGCACGTGGCAGCTTCCATGGAGATGTGAGAACCAC >In-frame_STK10_ENST00000176763_chr5_171583628_-_SH3PXD2B_ENST00000311601_chr5_171849500_-_8196nt CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGTCTACATCATCCGGGTCACGTGGTCCAGCGGCTCCACCGAGGCCATTTACCGGC GCTACAGCAAGTTTTTTGACCTCCAGATGCAGATGTTGGACAAATTTCCCATGGAAGGAGGACAGAAGGACCCCAAGCAGCGGATCATCC CCTTTCTGCCAGGTAAGATTCTCTTCAGACGAAGCCACATCCGGGACGTGGCTGTCAAACGCCTGATACCAATTGATGAATACTGTAAGG CCCTCATCCAGCTGCCCCCCTACATCTCTCAGTGTGATGAGGTGCTGCAGTTCTTTGAGACAAGACCTGAGGACCTGAATCCCCCCAAAG AGGAGCACATTGGGAAAAAGAAATCTGGGGGTGACCAAACCTCAGTGGACCCCATGGTCCTGGAGCAGTATGTGGTGGTAGCCAACTACC AGAAGCAGGAGAGTTCGGAGATCAGCCTCAGCGTGGGGCAGGTGGTGGACATCATCGAGAAGAATGAGTCAGGTTGGTGGTTCGTCAGCA CTGCCGAGGAGCAAGGCTGGGTCCCTGCAACGTGCCTCGAAGGCCAGGATGGGGTGCAGGATGAGTTTTCTCTGCAGCCTGAAGAAGAGG AGAAGTACACAGTCATCTACCCGTACACAGCTCGGGACCAGGATGAAATGAACCTGGAGAGAGGGGCTGTGGTGGAGGTCATCCAGAAAA ACCTGGAAGGCTGGTGGAAGATCAGGTACCAGGGCAAAGAAGGCTGGGCCCCCGCCTCCTACCTAAAGAAGAACAGTGGGGAGCCCTTGC CCCCGAAGCCAGGCCCTGGCTCACCCTCCCACCCGGGTGCCCTTGACTTGGATGGTGTTTCCCGGCAGCAGAACGCGGTGGGCAGGGAGA AGGAGCTGCTCAGCAGCCAGAGGGACGGGCGGTTTGAAGGCCGCCCGGTGCCCGACGGTGACGCCAAGCAGAGATCACCAAAGATGAGGC AGAGACCCCCTCCTCGCCGGGACATGACCATTCCTCGAGGCCTCAACCTGCCGAAGCCGCCCATCCCGCCCCAAGTGGAGGAAGAGTATT ACACCATCGCCGAATTCCAGACAACCATCCCAGACGGCATCAGCTTCCAGGCAGGCCTGAAGGTCGAGGTGATCGAGAAAAACTTGAGTG GCTGGTGGTACATTCAGATTGAAGATAAGGAAGGGTGGGCCCCGGCCACCTTCATTGACAAGTACAAGAAGACGAGCAACGCGTCGAGAC CCAACTTTCTGGCTCCCCTGCCCCACGAGGTGACCCAGCTCCGGCTGGGGGAAGCAGCAGCGCTGGAGAACAACACGGGCAGCGAAGCCA CGGGCCCCTCCCGGCCCCTGCCTGACGCACCGCATGGTGTCATGGACTCGGGGTTGCCATGGTCTAAAGACTGGAAGGGCAGTAAGGATG TCCTGAGGAAGGCATCTTCAGACATGTCTGCGTCAGCAGGCTACGAGGAGATCTCAGACCCCGACATGGAGGAGAAGCCCAGCCTCCCTC CGCGGAAAGAATCCATCATCAAGTCGGAGGGGGAGCTGCTGGAGCGGGAGCGGGAGCGGCAGAGGACGGAGCAGCTCCGGGGCCCCACTC CCAAGCCTCCGGGCGTGATTTTGCCGATGATGCCAGCCAAACACATCCCTCCAGCCCGGGACAGCAGGAGGCCAGAGCCCAAACCTGACA AAAGCAGACTGTTCCAGCTGAAAAATGACATGGGGCTGGAGTGTGGCCACAAGGTCTTGGCCAAGGAAGTGAAGAAGCCCAACCTCCGGC CCATCTCCAAATCCAAAACTGACCTGCCAGAGGAGAAGCCAGATGCCACTCCCCAGAATCCCTTCTTGAAGTCCAGACCTCAGGTTAGGC CAAAACCAGCTCCTTCCCCCAAAACGGAGCCACCTCAGGGCGAAGACCAAGTCGACATCTGCAACCTCAGGAGTAAGCTCAGGCCTGCCA AGTCCCAAGACAAGTCCTTGTTGGATGGGGAGGGCCCCCAGGCAGTAGGGGGCCAAGACGTGGCCTTCAGCCGAAGCTTCCTCCCAGGAG AGGGGCCTGGCCGCGCCCAGGACAGGACGGGCAAACAGGATGGTCTCAGCCCAAAAGAGATTTCCTGCAGAGCCCCTCCGAGGCCAGCCA AGACCACAGATCCTGTGTCTAAGAGCGTGCCTGTTCCTCTCCAAGAGGCTCCCCAGCAGAGACCTGTGGTCCCACCCCGCAGACCACCTC CCCCAAAGAAAACCTCTTCGTCATCCAGGCCGCTCCCAGAGGTCAGAGGTCCACAGTGTGAAGGCCACGAAAGCAGGGCAGCTCCCACCC CAGGCCGTGCTCTCCTCGTCCCTCCAAAAGCCAAACCTTTTCTCTCCAACTCTTTGGGGGGCCAGGATGACACGCGAGGCAAAGGCAGCC TGGGGCCATGGGGGACCGGCAAGATTGGAGAAAACAGGGAGAAAGCAGCTGCAGCCTCTGTCCCCAATGCCGACGGCCTGAAGGACTCTT TGTATGTGGCCGTGGCCGACTTTGAAGGAGACAAAGACACCAGCAGCTTCCAGGAAGGGACAGTGTTTGAAGTCCGGGAGAAGAACAGCA GTGGCTGGTGGTTCTGCCAGGTCCTGAGCGGAGCCCCTTCCTGGGAAGGGTGGATTCCTTCCAACTATCTCAGAAAGAAGCCGTAGCCGA CTCCCTTTCTGCCTAGAGGGCCCGCTGGTCCTTGCTGGCTTTACCCACGTATTTAATACGCCTCTTAATTTATCATTCTCCACGCAGCTT CCAAGGCAGACAGACTCTGGGGTACTGTGACTTCTTGCCTCCCATGGGTGGAGAGTGAGTTTCGGACACCTCGGGCGCCCCTGGGCCTGA TCCCTCCTATCACAGCATCACTGGAGGCTCAGAACCCACAGCCTTTGCTTTCTGTCCATGTCAGCATCCCTGCCTTAAGAGAACTCCTCC TGGCCAATGGCATTGCCACCCAGCAGTGGGACCAAGACTCTCCAAGACCTCCAGGACTGGATCCCATTGCCTGGAGAAACTCCAGCAAGG GTCTCTCATGGCTTGGACATGGCACAGTAAGGGGCAGCCAACCCAGTCCATGATGACTTTTGCTCCAACTTCTTCATGTTTCTAAAAGCC CAGTGGCTTTATTCACTCCTCCTAAATTGCCTGCTACCAGAAGGAACTTCATCCTGAAGAAATGCATTCCATTACCAGTTCCAGGGAAAG TGTCCCCTTCCCCAAAGCCTCAGGCCCGTGGGCCTCTGAGGTTCCACTGGATGCGGCTCCCCCAGGAGTGGGCCTGGAGATCCGCTCAGC CGCCCTGCCTCCCACCTTCTATCTTGGGACCGTGGTCAGCCCTGAAGGGTGGTTCCAGCCCCGCGTATGCTGCGCTTTGCTGCTGCAGGC TCCGGTCCCTCCAGGGCTTTTCAATGAGAGTTCCCACCCCAACTTGGAGCATTTCATTTTTGCCTACCTAAAGCAAGAATCTCAAAGTTT GTTTGAATAAGAGGCCCATTCACAAGTCGTGCCCTTGTGAGCACCCCTTTGCTGAGTGCCTCGTGGGTGCCAAACACTGTACTTGGCGCT TTGCATTCATGCTTTGACCCTCACAACCTCCCTTTATAGATGAGGAAATTCACGCTCCATGTGCCCAAGGACACACCAGCCAGGAGGAAG AGGGAAGAGGATTTGAGTCCAGGCCTGCCTGACTTCAGTGCCTGTGCCCTCCCCTCTGTAAAAGACAAACCAGGCAGGGAAGAGATAGAA GCTGGCTAAGTGGTGGCCAAGTGGCTTCATTGTGAGGGGGGTGAGGGGGCATTCGTGGCTGCTCCCACACCCACCATCCCTCCAGCCCAC AGCAGCCTATACCAAAGGCTGCCCTGGACTCAACAGCTGCATCTCCATGACAGGAGAATGCCAGGGTCCTGGTGGTTGACACAGAGCCCT GTTCCCTCTTCTAAGCTGTTGCCCCCTGGGGAATAGAGCTTATGGAGCAACGGGAGCTGAGGTGGCCTCGAGGGCCAGCCTGGAGGGCTC TGAGCATAGCATGCAGCGGTCCCATAGGGAGGCAGGTAACCAAGGGCCAGGCAGAGCTGCTTCCTGTGCCTCTCCGGCATTTGTAATGTT TTTTTCTTTTTTCACGCACTGCCAAATCTGTTTTCTCCCTTGAAGAAACCCAGGGCAGATGTGGTCATCTGTCAAACTGAGGTCTGGAGA GGCATGACTAAATCACTGCAGAAGCAAAATCAGGACCCAGCATTTCTAGCTCCCAGCCCAGAGTAAGAGAGCAGAGCAGAACCCCTTCCC ATTCTACCCGACCGAGGCAGCCCTGCCCTGCCCTGCCCCGCCCCTCCCCACCCTGCCCTGCCCCAGAGATCTCCAGTTCACAGTGTTCAT CAGGCGAGATACTTTTGGACCCACAAAGCCAGTTTTTTGGGGGGATGCTCAGTGTCTACCTGCAGTGCCAAAGTTTTGCTTGAACAGCCC TCTTCTGCCGCGCCTCCCAGCTCCACCCCCTATCACGTGGGTGCTGGCTGCTTCTGCGTGAGGAGCTTCCTCTGATCACCTGTAGCATCT TTAGTGCCTTCGTCCAGTCGGCCTGCAAATCCCATTTCCCAGAGAGGCTTGGGCAGGGCCCACTTGCCACTTGGCCCTGTGCCCAGAGCG TTGGGGGCAGATGGCAGCCAGGGGAAGAAGGGAGGTGGGGAAGGGCCGCCACCGCTTGAGGGTCCCCTCCCTTGAGAGGAGGCCCCATGG CAGTTTTCCTGAGTTCTTGATCCACTTTGGTTTAAACAACTTTTGTGAAGCTATGTGAGATTTGACTGCATTTCAAAAGACAAAACACAT GTTTTTTTCTGATTTGCTCTTTGCCTTTCAGCGACGCTTTCAGATACTTTGTGAGTGTCTACTCTGTGCTAGGTGCTGAGTAGACTGGGA TGTGTGTGGCTCCATCCCTGGCTGGAAGAGCTTTGAGTCCTGTCTGCTGACTTCACTGAAGGAGTTTCTCTCTTGCTTCATTCCTTCCTC CCGGGGGTCAGCTGGGTAGGAGCAGACTTGCCCTGCCTTCCTCTAGGCAGAAAGTTTTCCTGCAAATGAAAGAATCTGCCATTCTCTTTT GCTATGATGATGATGATTATTCTGACATGACCCGCGGGTACTGAAGCCACAGTCCTCTCTGTTCACTGTTCTCTCCTTGAGTCATATCTA TGGCCTGAGGACGTCTGTATCCAGCTCCTTTTCCTACAATGGTAGACACTTCCCCAGGCAGTGGGTGGGTCAGGGTGGCCAGTCACTCTC CTAGCTGTCCTTGCCTGGGGACTTAGATTTACCCCATCCAGGACTGTGGTCGCTATTCTGTGAGCGATTGATGGCGCATATGCAGAACTC CCCTGGAGTCATGGCTCTAGAAAGTGTCCAGGCCCATCGTGACAATGGTGCCAAGCACCGGGCTGGTGACCAGTGCCTAAACACACACGC TCCTTTAATCCTTACGGCAAGCCTGTGAGGCGGATAGGACCAGCCCTGATCTATAGTGAGAAAATTAAGGTTCAGAGGGAGAAGGTCCAA ATAGTGGCCAAGCTGGGACTGAGATCTCGAGTTTGGGTTTGTTTGGTTTTGTTGTTGTTGTTCTTTCCCTCGTGTCCATGACTTTTCTCT GCCATTAGCAGGGAAGTGTGCGGAGGGCTTCCAGGGAATCAAGTGACCCTCCCTCTGAATTTCGGTGCCTCTTCCCCCCGCCCCTTGCTC ACACATTTCAGTAGGTCACAGGCCAAATGGCAGCCCAAAAGGTGGGCAGAGATTTTTTTTTCTTCCCCTCACCCCTGCTTATTAACACAA TTGTGACAACTACTTTACCTTACATCCCAGGGCAAACGGACAGCTTGCGGTACCTCCAAAAATTTGGAAAACCCTGAGTCTAAGACCACC TCTTGATAAAAGAGGCCTTTGCTCACATGTTCTGCTCGGAATCTTTCTTTGCCATTGGTGGGTGTATGTCGTCCCAGCTGAGACTGCGGG AGAGCTGAGCTCCAGCTTAAACCGCTTTTAATGGCCCTTCCCTACTGGGGGATCGCTGGAGCCCATGCCAGGTTACGGTAGTCATTTTAA ACCTCTGCCACAAGGCCACGCCATAGAATCAATTTCCAAGTCAATGTTCTTGGCCCTAAAATGTTTGCGCCCACTGAGGATTTCATTACC AGGTGGAAGATGGGGGAACATATGCCACGTTAAAGAGCAAGTGCTGAGTGTGCCAGGACTTGAGAAGGACCTTAGGCTGAGGAGTGGACA GTCTGGTATTTATTTCGCCTCTCCCAAGTACCCAGCACAGAGTGGGAAAAAGAAGAAACTGCTCCTGCCTTCCAGTAGCTGGCAACTTGA CATCAAGAACAAAAACATTCGTAGCTGGACCCCCGTCCTTTCATCGTGCCCAAGTCTTACATGTTGGCTTAAGCTGCCCCCTTGGAGGCC GTACCTTTCTCTTTGGACTGTGACAGTGGACACCTAACAGCCTGAGCCATGTGTGGCTGTCTTATCCCCCAAGGGTTGTCCAGGCCCGTT CTGCAGGGCTGTTGTGTAGACTGCAGACATCCATACCTCACCACAGACCAAAGATGACCTCGTGTCAGACTGTGGGCTGATGAGAGGTAG AGCAGCATGCATCGAGGCCTGAGGGTGCAGGGCGCCCTCTCTTGGCCTGGAGGAATTGCTCCTAACTAGAGTAAGTTTCCACGAGGGTCC CAGGCAGAGCTGCAGAGCTGGAACCGGAGGCTCCACAGTCCTTGCCTGCTCATGGACCTCCTTCAGAGCACCTTTCTACAGACTGGACTG CCCAGCTCCGTGGGGTGGCATCTGGTTTCTGGTGCTATTCTGCCAAGTTATCGAGCTCCTCCTCATGTTTCAACATTCCATCTTCCCGTT TCTATCCTCGACTCCAAAGTAAGCCTTCTTAGCTCCAATCAGGGATGAGGGGCTCAACCTCTTCTGTCCTCAAAGAGGCCAAACGCAGTG CCACAGTCGGTAGCCTTCACTTTTAGATGTCCTATTCATGTAAAAAAGAAGGTGCCCCCACCAGGCTTACATCAGCAATAAGCAATTCTA ATGCAACGATGGTGTCCACATTTTACCCCAGTGTGTGCCCATGTATGCCTTTGTGCCCGTGTAATTATTGTTAGCGCCCCTTTCACTTAG AGGGGTGATGATAAACTGTGGCCACCTTGATTACAACCCACATTTCCTGCTTTGGGGAGCTTCCAAGTAACAGGCCATTTCTTACCTCCC TCCAGGAACAGTGGGCACTGCCCACCACCTCGTGTCTGCTCATAGGATGACGCTGGAGATCCCCACACTTACTCTACCCTCTTGGCAAAT TGGCATTCCGGTGGTGGTTTTTGTTTCCTTTAACACATTAAATAAATGAGTATATAGGATGTGAGGGGAGGGGTGAGAACAACTAGCTGT AGCATGTGTAGGCTATATACTTTACCATTTGACTTCTTTCCTTTTTTTTTTTTTAAATAAAAAAAGTGCTTGACTGGTTTCAAGCTTCAT |
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FusionGenePPI for STK10_SH3PXD2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STK10 | CD81, ENO1, SHMT2, MOV10, NXF1, KIFC1, XPO1, TRIM25 | SH3PXD2B | SH3KBP1, FASLG, DIS3, GRB2, NCK2, ACAA2, LZTFL1, TATDN1, NTRK1, KRAS, LIMK1, SORT1, CDH1, ITFG2, ZNF764 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK10_SH3PXD2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK10_SH3PXD2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | STK10 | C1336708 | Testicular Germ Cell Tumor | 1 | UNIPROT |
| Tgene | SH3PXD2B | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Tgene | SH3PXD2B | C0015393 | Eye Abnormalities | 1 | CTD_human |
| Tgene | SH3PXD2B | C0018273 | Growth Disorders | 1 | CTD_human |
| Tgene | SH3PXD2B | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | SH3PXD2B | C1384666 | hearing impairment | 1 | CTD_human |
| Tgene | SH3PXD2B | C1855305 | Ter Haar syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
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