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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36468

FusionGeneSummary for STIP1_PC

check button Fusion gene summary
Fusion gene informationFusion gene name: STIP1_PC
Fusion gene ID: 36468
HgeneTgene
Gene symbol

STIP1

PC

Gene ID

10963

5420

Gene namestress induced phosphoprotein 1podocalyxin like
SynonymsHEL-S-94n|HOP|IEF-SSP-3521|P60|STI1|STI1LGp200|PC|PCLP|PCLP-1
Cytomap

11q13.1

7q32.3

Type of geneprotein-codingprotein-coding
Descriptionstress-induced-phosphoprotein 1Hsp70/Hsp90-organizing proteinNY-REN-11 antigenepididymis secretory sperm binding protein Li 94nhsc70/Hsp90-organizing proteinrenal carcinoma antigen NY-REN-11transformation-sensitive protein IEF SSP 3521podocalyxinGCTM-2 antigenpodocalyxin-like protein 1
Modification date2018052320180527
UniProtAcc

P31948

P11498

Ensembl transtripts involved in fusion geneENST00000358794, ENST00000305218, 
ENST00000538945, ENST00000543847, 
ENST00000540501, 		ENST00000393958, 
ENST00000393960, ENST00000355677, 
ENST00000524491, ENST00000529047, 
ENST00000393955, ENST00000528224, 
Fusion gene scores* DoF score7 X 4 X 5=1409 X 5 X 7=315
# samples 79
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STIP1 [Title/Abstract] AND PC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePC

GO:0030335

positive regulation of cell migration

18456258

TgenePC

GO:0033634

positive regulation of cell-cell adhesion mediated by integrin

18456258


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-77-8148-01ASTIP1chr11

63967765

+PCchr11

66719939

-
TCGALDLUSCTCGA-77-8148-01ASTIP1chr11

63967765

+PCchr11

66721907

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358794ENST00000393958STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000358794ENST00000393960STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000358794ENST00000355677STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000358794ENST00000524491STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000358794ENST00000529047STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000358794ENST00000393955STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000358794ENST00000528224STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000305218ENST00000393958STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000305218ENST00000393960STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000305218ENST00000355677STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000305218ENST00000524491STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000305218ENST00000529047STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000305218ENST00000393955STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000305218ENST00000528224STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000538945ENST00000393958STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000538945ENST00000393960STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000538945ENST00000355677STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-5UTRENST00000538945ENST00000524491STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000538945ENST00000529047STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000538945ENST00000393955STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000538945ENST00000528224STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000543847ENST00000393958STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000543847ENST00000393960STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000543847ENST00000355677STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000543847ENST00000524491STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000543847ENST00000529047STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000543847ENST00000393955STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000543847ENST00000528224STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000540501ENST00000393958STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000540501ENST00000393960STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000540501ENST00000355677STIP1chr11

63967765

+PCchr11

66719939

-
intron-5UTRENST00000540501ENST00000524491STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000540501ENST00000529047STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000540501ENST00000393955STIP1chr11

63967765

+PCchr11

66719939

-
intron-intronENST00000540501ENST00000528224STIP1chr11

63967765

+PCchr11

66719939

-
5CDS-intronENST00000358794ENST00000393958STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-5UTRENST00000358794ENST00000393960STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000358794ENST00000355677STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000358794ENST00000524491STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000358794ENST00000529047STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000358794ENST00000393955STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000358794ENST00000528224STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000393958STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-5UTRENST00000305218ENST00000393960STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000355677STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000524491STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000529047STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000393955STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000305218ENST00000528224STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000393958STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-5UTRENST00000538945ENST00000393960STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000355677STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000524491STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000529047STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000393955STIP1chr11

63967765

+PCchr11

66721907

-
5CDS-intronENST00000538945ENST00000528224STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000393958STIP1chr11

63967765

+PCchr11

66721907

-
intron-5UTRENST00000543847ENST00000393960STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000355677STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000524491STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000529047STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000393955STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000543847ENST00000528224STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000393958STIP1chr11

63967765

+PCchr11

66721907

-
intron-5UTRENST00000540501ENST00000393960STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000355677STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000524491STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000529047STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000393955STIP1chr11

63967765

+PCchr11

66721907

-
intron-intronENST00000540501ENST00000528224STIP1chr11

63967765

+PCchr11

66721907

-

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FusionProtFeatures for STIP1_PC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STIP1

P31948

PC

P11498

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360).Mediates the association of the molecular chaperones HSPA8/HSC70and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814,ECO:0000303|PubMed:27353360}. Pyruvate carboxylase catalyzes a 2-step reaction,involving the ATP-dependent carboxylation of the covalentlyattached biotin in the first step and the transfer of the carboxylgroup to pyruvate in the second. Catalyzes in a tissue specificmanner, the initial reactions of glucose (liver, kidney) and lipid(adipose tissue, liver, brain) synthesis from pyruvate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STIP1_PC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STIP1_PC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STIP1WRAP73, NME2, POU2F1, GAPDH, NPAT, HSPA14, HSP90AA1, HSPA4, PRNP, USP49, EGFR, FKBP5, FKBP4, AIP, RIPK3, PSMA3, ACD, POT1, IRAK1, APP, HSP90AB1, AHCYL1, IGBP1, SSSCA1, HSPA8, NASP, STMN1, PSMC3, PSMC6, KCNH2, KCNQ4, FN1, VCAM1, ATF2, PPP5C, NOS2, METTL21B, ITGA4, SLC12A3, MAP3K8, LMO2, CDK3, CDK9, CDK5, COPS4, CDC37L1, CCDC117, BAG2, DNAJB6, MLF2, CUL7, CCDC8, MAP1S, AMBRA1, AKR1B1, AKR1B15, DNAJA2, DUT, ENO2, ENO3, FABP5, HSPE1, ME1, MSI2, PCBP1, PCBP2, PGK1, PGP, PLS3, PPID, RPS6KA3, ACLY, AHNAK, AHSA1, ALDH1B1, ARFIP1, ASS1, DLD, DNAJB1, DNAJB4, ELAVL1, EZR, GDI2, GLO1, GPX4, GRPEL1, HINT1, HNRNPDL, HNRNPH3, HSD17B10, HSPA1A, HSPA1B, HSPA2, HSPA5, HSPB1, HSPH1, ITPA, MSN, NME1-NME2, PEBP1, PHGDH, PPA1, PTGES3, RDX, SOD1, SRSF2, TAGLN, TAGLN2, TAGLN3, TKT, TPR, TRIP6, TXN, UCHL3, UFD1L, VCP, SUMO3, SUMO4, TPI1, NTRK1, PACRG, PTEN, KIAA0753, CCDC14, EWSR1, CLK1, OFD1, NPHP4, EVC2, NEK8, DNAJC7, TUBG1, XRCC3, TUBA1C, NLRP5, MCM2, U2AF2, EIF2S2, CLCN1, FLCN, FNIP1, FNIP2, PPEF2, CDC25A, CDC25C, EYA3, MTM1, SBF1, MTMR8, HSP90AA5P, HSP90AB3P, HSP90AA4P, HSP90AB4P, PNPLA5, DNAI2, TRIML2, NOX5, HAO2, UBE3D, ABHD15, TAF6L, CAPN5, KLHL34, CFAP52, PTPN18, SSH3, TPTE, DDX59, DNM1L, TRIM25, G3BP1, BRCA1, TXNIP, SLC6A4, ADH5PCMDH2, GOT1, NPM1, UBE2N, ILF2, ILF3, MTHFD1, CDH2, RPS3A, NACA, PPT2, PRKCDBP, TUFM, IFIT1, ADRB2, HECW2, HUWE1, EGFR, TSHR, KLK5, DTWD2, ANTXR1, DNASE2B, CBWD1, PSG1, THBS3, CAD, CCT6A, COPB1, CYP27A1, FASN, KPNA4, ATP1A1, CANX, CCT3, GNB2, PPP2R1A, RPN1, RPN2, SLC25A3, PFAS, UQCRC2, NTRK1, PTEN, ERBB2, XRCC3, RAB7A, DYNLL1, WWP2, ZNF746, PTPN9, STRAP, DEFA5, ASS1, HSD3B2, BPNT1, SLAMF1, LRP1, TPSB2, YBEY, EPHA7, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STIP1_PC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePCP11498DB00121BiotinPyruvate carboxylase, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for STIP1_PC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTIP1C0011581Depressive disorder1PSYGENET
HgeneSTIP1C0025202melanoma1CTD_human
TgenePCC0006413Burkitt Lymphoma1CTD_human
TgenePCC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePCC0034341Pyruvate Carboxylase Deficiency Disease1CTD_human;UNIPROT