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Fusion gene ID: 36462 |
FusionGeneSummary for STIM2_SPIDR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STIM2_SPIDR | Fusion gene ID: 36462 | Hgene | Tgene | Gene symbol | STIM2 | SPIDR | Gene ID | 57620 | 23514 |
| Gene name | stromal interaction molecule 2 | scaffold protein involved in DNA repair | |
| Synonyms | - | KIAA0146 | |
| Cytomap | 4p15.2 | 8q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stromal interaction molecule 2 | DNA repair-scaffolding proteinscaffolding protein involved in DNA repair | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9P246 | Q14159 | |
| Ensembl transtripts involved in fusion gene | ENST00000382009, ENST00000237364, ENST00000467087, ENST00000412829, ENST00000467011, ENST00000465503, ENST00000478425, | ENST00000297423, ENST00000518074, ENST00000541342, ENST00000521214, ENST00000517693, ENST00000518060, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 12 X 13 X 8=1248 |
| # samples | 4 | 18 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STIM2 [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STIM2 | GO:0032237 | activation of store-operated calcium channel activity | 17905723 |
| Hgene | STIM2 | GO:0051928 | positive regulation of calcium ion transport | 17905723 |
| Tgene | SPIDR | GO:0006974 | cellular response to DNA damage stimulus | 23509288 |
| Tgene | SPIDR | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Tgene | SPIDR | GO:0031334 | positive regulation of protein complex assembly | 23509288 |
| Tgene | SPIDR | GO:0070202 | regulation of establishment of protein localization to chromosome | 23509288 |
| Tgene | SPIDR | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Tgene | SPIDR | GO:0072711 | cellular response to hydroxyurea | 23509288 |
| Tgene | SPIDR | GO:0072757 | cellular response to camptothecin | 23509288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-A48Z-01A | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000382009 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000382009 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000382009 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000382009 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000382009 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000382009 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| Frame-shift | ENST00000237364 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000237364 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000237364 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000237364 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000237364 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000237364 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| Frame-shift | ENST00000467087 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000467087 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000467087 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000467087 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000467087 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000467087 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| Frame-shift | ENST00000412829 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000412829 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000412829 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000412829 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000412829 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000412829 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| Frame-shift | ENST00000467011 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000467011 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000467011 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000467011 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000467011 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000467011 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| Frame-shift | ENST00000465503 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000465503 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-5UTR | ENST00000465503 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-3UTR | ENST00000465503 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000465503 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| 5CDS-intron | ENST00000465503 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-3CDS | ENST00000478425 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-5UTR | ENST00000478425 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-5UTR | ENST00000478425 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-3UTR | ENST00000478425 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-intron | ENST00000478425 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
| intron-intron | ENST00000478425 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
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FusionProtFeatures for STIM2_SPIDR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STIM2 | SPIDR |
| Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores. Functions as a highly sensitive Ca(2+) sensor inthe endoplasmic reticulum which activates both store-operated andstore-independent Ca(2+)-influx. Regulates basal cytosolic andendoplasmic reticulum Ca(2+) concentrations. Upon mild variationsof the endoplasmic reticulum Ca(2+) concentration, translocatesfrom the endoplasmic reticulum to the plasma membrane where itprobably activates the Ca(2+) release-activated Ca(2+) (CRAC)channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+)influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747,ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041,ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749,ECO:0000269|PubMed:23359669}. | Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STIM2_SPIDR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STIM2_SPIDR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STIM2 | STIM1, PRKAA2, PRKAB2, CALM1, PRPF40A, HEXA, HEXB, TMEM17, BRINP3, PRKAA1, PRKAG2, PRKAG1, PRKAB1, MSRB3, SUMF1, CISD2, TMLHE, HMOX1 | SPIDR | FOXL1, PLA2G10, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STIM2_SPIDR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STIM2_SPIDR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STIM2 | C0043094 | Weight Gain | 1 | CTD_human |
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