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Fusion gene ID: 36462 |
FusionGeneSummary for STIM2_SPIDR |
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Fusion gene information | Fusion gene name: STIM2_SPIDR | Fusion gene ID: 36462 | Hgene | Tgene | Gene symbol | STIM2 | SPIDR | Gene ID | 57620 | 23514 |
Gene name | stromal interaction molecule 2 | scaffold protein involved in DNA repair | |
Synonyms | - | KIAA0146 | |
Cytomap | 4p15.2 | 8q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | stromal interaction molecule 2 | DNA repair-scaffolding proteinscaffolding protein involved in DNA repair | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9P246 | Q14159 | |
Ensembl transtripts involved in fusion gene | ENST00000382009, ENST00000237364, ENST00000467087, ENST00000412829, ENST00000467011, ENST00000465503, ENST00000478425, | ENST00000297423, ENST00000518074, ENST00000541342, ENST00000521214, ENST00000517693, ENST00000518060, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 12 X 13 X 8=1248 |
# samples | 4 | 18 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STIM2 [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STIM2 | GO:0032237 | activation of store-operated calcium channel activity | 17905723 |
Hgene | STIM2 | GO:0051928 | positive regulation of calcium ion transport | 17905723 |
Tgene | SPIDR | GO:0006974 | cellular response to DNA damage stimulus | 23509288 |
Tgene | SPIDR | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
Tgene | SPIDR | GO:0031334 | positive regulation of protein complex assembly | 23509288 |
Tgene | SPIDR | GO:0070202 | regulation of establishment of protein localization to chromosome | 23509288 |
Tgene | SPIDR | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
Tgene | SPIDR | GO:0072711 | cellular response to hydroxyurea | 23509288 |
Tgene | SPIDR | GO:0072757 | cellular response to camptothecin | 23509288 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-55-A48Z-01A | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000382009 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000382009 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000382009 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000382009 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000382009 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000382009 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
Frame-shift | ENST00000237364 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000237364 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000237364 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000237364 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000237364 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000237364 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
Frame-shift | ENST00000467087 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000467087 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000467087 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000467087 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000467087 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000467087 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
Frame-shift | ENST00000412829 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000412829 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000412829 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000412829 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000412829 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000412829 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
Frame-shift | ENST00000467011 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000467011 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000467011 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000467011 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000467011 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000467011 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
Frame-shift | ENST00000465503 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000465503 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-5UTR | ENST00000465503 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-3UTR | ENST00000465503 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000465503 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
5CDS-intron | ENST00000465503 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-3CDS | ENST00000478425 | ENST00000297423 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-5UTR | ENST00000478425 | ENST00000518074 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-5UTR | ENST00000478425 | ENST00000541342 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-3UTR | ENST00000478425 | ENST00000521214 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-intron | ENST00000478425 | ENST00000517693 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
intron-intron | ENST00000478425 | ENST00000518060 | STIM2 | chr4 | 27019606 | + | SPIDR | chr8 | 48192450 | + |
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FusionProtFeatures for STIM2_SPIDR |
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Hgene | Tgene |
STIM2 | SPIDR |
Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores. Functions as a highly sensitive Ca(2+) sensor inthe endoplasmic reticulum which activates both store-operated andstore-independent Ca(2+)-influx. Regulates basal cytosolic andendoplasmic reticulum Ca(2+) concentrations. Upon mild variationsof the endoplasmic reticulum Ca(2+) concentration, translocatesfrom the endoplasmic reticulum to the plasma membrane where itprobably activates the Ca(2+) release-activated Ca(2+) (CRAC)channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+)influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747,ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041,ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749,ECO:0000269|PubMed:23359669}. | Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STIM2_SPIDR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STIM2_SPIDR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STIM2 | STIM1, PRKAA2, PRKAB2, CALM1, PRPF40A, HEXA, HEXB, TMEM17, BRINP3, PRKAA1, PRKAG2, PRKAG1, PRKAB1, MSRB3, SUMF1, CISD2, TMLHE, HMOX1 | SPIDR | FOXL1, PLA2G10, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STIM2_SPIDR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STIM2_SPIDR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STIM2 | C0043094 | Weight Gain | 1 | CTD_human |