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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36462

FusionGeneSummary for STIM2_SPIDR

check button Fusion gene summary
Fusion gene informationFusion gene name: STIM2_SPIDR
Fusion gene ID: 36462
HgeneTgene
Gene symbol

STIM2

SPIDR

Gene ID

57620

23514

Gene namestromal interaction molecule 2scaffold protein involved in DNA repair
Synonyms-KIAA0146
Cytomap

4p15.2

8q11.21

Type of geneprotein-codingprotein-coding
Descriptionstromal interaction molecule 2DNA repair-scaffolding proteinscaffolding protein involved in DNA repair
Modification date2018052320180523
UniProtAcc

Q9P246

Q14159

Ensembl transtripts involved in fusion geneENST00000382009, ENST00000237364, 
ENST00000467087, ENST00000412829, 
ENST00000467011, ENST00000465503, 
ENST00000478425, 
ENST00000297423, 
ENST00000518074, ENST00000541342, 
ENST00000521214, ENST00000517693, 
ENST00000518060, 
Fusion gene scores* DoF score4 X 4 X 4=6412 X 13 X 8=1248
# samples 418
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STIM2 [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTIM2

GO:0032237

activation of store-operated calcium channel activity

17905723

HgeneSTIM2

GO:0051928

positive regulation of calcium ion transport

17905723

TgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

TgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

TgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

TgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

TgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-A48Z-01ASTIM2chr4

27019606

+SPIDRchr8

48192450

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382009ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000382009ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000382009ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000382009ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000382009ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000382009ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
Frame-shiftENST00000237364ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000237364ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000237364ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000237364ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000237364ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000237364ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
Frame-shiftENST00000467087ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000467087ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000467087ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000467087ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000467087ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000467087ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
Frame-shiftENST00000412829ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000412829ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000412829ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000412829ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000412829ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000412829ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
Frame-shiftENST00000467011ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000467011ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000467011ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000467011ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000467011ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000467011ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
Frame-shiftENST00000465503ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000465503ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-5UTRENST00000465503ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-3UTRENST00000465503ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000465503ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
5CDS-intronENST00000465503ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-3CDSENST00000478425ENST00000297423STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-5UTRENST00000478425ENST00000518074STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-5UTRENST00000478425ENST00000541342STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-3UTRENST00000478425ENST00000521214STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-intronENST00000478425ENST00000517693STIM2chr4

27019606

+SPIDRchr8

48192450

+
intron-intronENST00000478425ENST00000518060STIM2chr4

27019606

+SPIDRchr8

48192450

+

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FusionProtFeatures for STIM2_SPIDR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STIM2

Q9P246

SPIDR

Q14159

Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores. Functions as a highly sensitive Ca(2+) sensor inthe endoplasmic reticulum which activates both store-operated andstore-independent Ca(2+)-influx. Regulates basal cytosolic andendoplasmic reticulum Ca(2+) concentrations. Upon mild variationsof the endoplasmic reticulum Ca(2+) concentration, translocatesfrom the endoplasmic reticulum to the plasma membrane where itprobably activates the Ca(2+) release-activated Ca(2+) (CRAC)channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+)influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747,ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041,ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749,ECO:0000269|PubMed:23359669}. Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STIM2_SPIDR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STIM2_SPIDR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STIM2STIM1, PRKAA2, PRKAB2, CALM1, PRPF40A, HEXA, HEXB, TMEM17, BRINP3, PRKAA1, PRKAG2, PRKAG1, PRKAB1, MSRB3, SUMF1, CISD2, TMLHE, HMOX1SPIDRFOXL1, PLA2G10, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STIM2_SPIDR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STIM2_SPIDR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTIM2C0043094Weight Gain1CTD_human