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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36461

FusionGeneSummary for STIM2_PPIG

check button Fusion gene summary
Fusion gene informationFusion gene name: STIM2_PPIG
Fusion gene ID: 36461
HgeneTgene
Gene symbol

STIM2

PPIG

Gene ID

57620

9360

Gene namestromal interaction molecule 2peptidylprolyl isomerase G
Synonyms-CARS-Cyp|CYP|SCAF10|SRCyp
Cytomap

4p15.2

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionstromal interaction molecule 2peptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G
Modification date2018052320180523
UniProtAcc

Q9P246

Q13427

Ensembl transtripts involved in fusion geneENST00000382009, ENST00000237364, 
ENST00000467087, ENST00000412829, 
ENST00000467011, ENST00000465503, 
ENST00000478425, 		ENST00000260970, 
ENST00000409714, ENST00000462903, 
ENST00000448752, ENST00000482772, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 5 X 1=20
# samples 47
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/20*10)=1.8073549220576
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STIM2 [Title/Abstract] AND PPIG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTIM2

GO:0032237

activation of store-operated calcium channel activity

17905723

HgeneSTIM2

GO:0051928

positive regulation of calcium ion transport

17905723

TgenePPIG

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF930056STIM2chr4

26932226

-PPIGchr2

170492692

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382009ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000382009ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000382009ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000382009ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000382009ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000237364ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000237364ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000237364ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000237364ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000237364ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000467087ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000467087ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000467087ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000467087ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000467087ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000412829ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000412829ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000412829ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000412829ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000412829ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000467011ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000467011ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000467011ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000467011ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000467011ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000465503ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000465503ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000465503ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000465503ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000465503ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000478425ENST00000260970STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3CDSENST00000478425ENST00000409714STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000478425ENST00000462903STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-intronENST00000478425ENST00000448752STIM2chr4

26932226

-PPIGchr2

170492692

+
intron-3UTRENST00000478425ENST00000482772STIM2chr4

26932226

-PPIGchr2

170492692

+

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FusionProtFeatures for STIM2_PPIG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STIM2

Q9P246

PPIG

Q13427

Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores. Functions as a highly sensitive Ca(2+) sensor inthe endoplasmic reticulum which activates both store-operated andstore-independent Ca(2+)-influx. Regulates basal cytosolic andendoplasmic reticulum Ca(2+) concentrations. Upon mild variationsof the endoplasmic reticulum Ca(2+) concentration, translocatesfrom the endoplasmic reticulum to the plasma membrane where itprobably activates the Ca(2+) release-activated Ca(2+) (CRAC)channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+)influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747,ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041,ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749,ECO:0000269|PubMed:23359669}. PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be implicated in thefolding, transport, and assembly of proteins. May play animportant role in the regulation of pre-mRNA splicing.{ECO:0000269|PubMed:20676357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STIM2_PPIG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STIM2_PPIG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STIM2_PPIG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STIM2_PPIG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTIM2C0043094Weight Gain1CTD_human