FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36460

FusionGeneSummary for STIM2_GATAD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: STIM2_GATAD2A
Fusion gene ID: 36460
HgeneTgene
Gene symbol

STIM2

GATAD2A

Gene ID

57620

54815

Gene namestromal interaction molecule 2GATA zinc finger domain containing 2A
Synonyms-p66alpha
Cytomap

4p15.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionstromal interaction molecule 2transcriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A
Modification date2018052320180523
UniProtAcc

Q9P246

Q86YP4

Ensembl transtripts involved in fusion geneENST00000382009, ENST00000237364, 
ENST00000467087, ENST00000412829, 
ENST00000467011, ENST00000465503, 
ENST00000478425, 
ENST00000252577, 
ENST00000360315, ENST00000537887, 
ENST00000404158, ENST00000358713, 
ENST00000429563, ENST00000473184, 
Fusion gene scores* DoF score4 X 4 X 4=648 X 7 X 7=392
# samples 49
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STIM2 [Title/Abstract] AND GATAD2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTIM2

GO:0032237

activation of store-operated calcium channel activity

17905723

HgeneSTIM2

GO:0051928

positive regulation of calcium ion transport

17905723

TgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-22-A5C4-01ASTIM2chr4

26921256

+GATAD2Achr19

19576149

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000382009ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000382009ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000382009ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000382009ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000382009ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000382009ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000382009ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000237364ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000237364ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000237364ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000237364ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000237364ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000237364ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000237364ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467087ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467087ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467087ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467087ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467087ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000467087ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000467087ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000412829ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000412829ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000412829ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000412829ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000412829ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000412829ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000412829ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467011ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467011ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467011ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467011ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000467011ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000467011ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000467011ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000465503ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000465503ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000465503ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000465503ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000465503ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000465503ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
5CDS-intronENST00000465503ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-5UTRENST00000478425ENST00000252577STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-5UTRENST00000478425ENST00000360315STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-5UTRENST00000478425ENST00000537887STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-5UTRENST00000478425ENST00000404158STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-5UTRENST00000478425ENST00000358713STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-intronENST00000478425ENST00000429563STIM2chr4

26921256

+GATAD2Achr19

19576149

+
intron-intronENST00000478425ENST00000473184STIM2chr4

26921256

+GATAD2Achr19

19576149

+

Top

FusionProtFeatures for STIM2_GATAD2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STIM2

Q9P246

GATAD2A

Q86YP4

Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores. Functions as a highly sensitive Ca(2+) sensor inthe endoplasmic reticulum which activates both store-operated andstore-independent Ca(2+)-influx. Regulates basal cytosolic andendoplasmic reticulum Ca(2+) concentrations. Upon mild variationsof the endoplasmic reticulum Ca(2+) concentration, translocatesfrom the endoplasmic reticulum to the plasma membrane where itprobably activates the Ca(2+) release-activated Ca(2+) (CRAC)channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+)influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747,ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041,ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749,ECO:0000269|PubMed:23359669}. Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2B.{ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STIM2_GATAD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STIM2_GATAD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STIM2STIM1, PRKAA2, PRKAB2, CALM1, PRPF40A, HEXA, HEXB, TMEM17, BRINP3, PRKAA1, PRKAG2, PRKAG1, PRKAB1, MSRB3, SUMF1, CISD2, TMLHE, HMOX1GATAD2AMBD2, MBD3, HDAC1, RBBP4, RBBP7, HIST2H2AC, HIST2H2BE, HIST1H3A, HIST1H4A, CHD4, SOX2, CHD7, ELAVL1, MTA2, HDAC2, CHD3, MTA3, KRT40, OBSL1, PSME3, ZNF219, PHF20L1, FAM219A, MBD3L1, ZBTB46, CHD5, GATAD2B, MTA1, RUVBL1, KRAS, HIST1H3E, KPNA1, TCF20, CDK2AP1, HMG20A, ZMYND8, ZNF687, NABP2, RBPJ, NFATC2, ZNF592, APPBP2, CPNE5, IKZF1, DLD, TRIM25, ZNF827


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STIM2_GATAD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STIM2_GATAD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTIM2C0043094Weight Gain1CTD_human