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Fusion gene ID: 36459 |
FusionGeneSummary for STIM1_VHL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STIM1_VHL | Fusion gene ID: 36459 | Hgene | Tgene | Gene symbol | STIM1 | VHL | Gene ID | 6786 | 7428 |
| Gene name | stromal interaction molecule 1 | von Hippel-Lindau tumor suppressor | |
| Synonyms | D11S4896E|GOK|IMD10|STRMK|TAM|TAM1 | HRCA1|RCA1|VHL1|pVHL | |
| Cytomap | 11p15.4 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stromal interaction molecule 1 | von Hippel-Lindau disease tumor suppressorelongin binding proteinprotein G7von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13586 | P40337 | |
| Ensembl transtripts involved in fusion gene | ENST00000300737, ENST00000527651, ENST00000527484, ENST00000533977, | ENST00000256474, ENST00000345392, ENST00000477538, | |
| Fusion gene scores | * DoF score | 12 X 8 X 8=768 | 3 X 2 X 3=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/768*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STIM1 [Title/Abstract] AND VHL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STIM1 | GO:0002115 | store-operated calcium entry | 28219928 |
| Hgene | STIM1 | GO:0005513 | detection of calcium ion | 16005298 |
| Hgene | STIM1 | GO:0032237 | activation of store-operated calcium channel activity | 16005298|26322679|28219928 |
| Hgene | STIM1 | GO:0051924 | regulation of calcium ion transport | 16005298 |
| Tgene | VHL | GO:0016567 | protein ubiquitination | 24899725 |
| Tgene | VHL | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 11641274 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-66-2766-01A | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000300737 | ENST00000256474 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| In-frame | ENST00000300737 | ENST00000345392 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| 5CDS-3UTR | ENST00000300737 | ENST00000477538 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| In-frame | ENST00000527651 | ENST00000256474 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| In-frame | ENST00000527651 | ENST00000345392 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| 5CDS-3UTR | ENST00000527651 | ENST00000477538 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3CDS | ENST00000527484 | ENST00000256474 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3CDS | ENST00000527484 | ENST00000345392 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3UTR | ENST00000527484 | ENST00000477538 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3CDS | ENST00000533977 | ENST00000256474 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3CDS | ENST00000533977 | ENST00000345392 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
| intron-3UTR | ENST00000533977 | ENST00000477538 | STIM1 | chr11 | 3877639 | + | VHL | chr3 | 10191471 | + |
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FusionProtFeatures for STIM1_VHL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STIM1 | VHL |
| Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellularCa(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375,PubMed:16537481, PubMed:16733527, PubMed:16766533,PubMed:16807233, PubMed:18854159, PubMed:19249086,PubMed:22464749, PubMed:24069340, PubMed:24351972,PubMed:24591628, PubMed:26322679, PubMed:25326555,PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmicreticulum via its EF-hand domain. Upon Ca(2+) depletion,translocates from the endoplasmic reticulum to the plasma membranewhere it activates the Ca(2+) release-activated Ca(2+) (CRAC)channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involvedin enamel formation (PubMed:24621671). Activated followinginteraction with STIMATE, leading to promote STIM1 conformationalswitch (PubMed:26322679). {ECO:0000269|PubMed:15866891,ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375,ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527,ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233,ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086,ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340,ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628,ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555,ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928}. | Involved in the ubiquitination and subsequentproteasomal degradation via the von Hippel-Lindau ubiquitinationcomplex. Seems to act as a target recruitment subunit in the E3ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved intranscriptional repression through interaction with HIF1A, HIF1ANand histone deacetylases. Ubiquitinates, in an oxygen-responsivemanner, ADRB2. {ECO:0000269|PubMed:10944113,ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 76_87 | 46 | 686 | Calcium binding | . |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 248_442 | 46 | 686 | Coiled coil | Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269 |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 270_336 | 46 | 686 | Compositional bias | Note=Glu-rich |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 600_629 | 46 | 686 | Compositional bias | Note=Pro/Ser-rich |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 672_685 | 46 | 686 | Compositional bias | Note=Lys-rich |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 132_200 | 46 | 686 | Domain | SAM |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 63_98 | 46 | 686 | Domain | Note=EF-hand |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 642_645 | 46 | 686 | Motif | Note=Microtubule tip localization signal |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 334_444 | 46 | 686 | Region | Note=SOAR/CAD |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 235_685 | 46 | 686 | Topological domain | Cytoplasmic |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 23_213 | 46 | 686 | Topological domain | Extracellular |
| Hgene | >STIM1 | chr11:3877639 | chr3:10191471 | ENST00000300737 | + | 1 | 12 | 214_234 | 46 | 686 | Transmembrane | Helical |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 100_155 | 154 | 214 | Region | Note=Involved in binding to CCT complex |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 14_53 | 154 | 214 | Region | Note=8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE] |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 100_155 | 113 | 173 | Region | Note=Involved in binding to CCT complex |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 14_53 | 113 | 173 | Region | Note=8 X 5 AA tandem repeats of G-[PAVG]-E-E-[DAYSLE] |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 14_18 | 154 | 214 | Repeat | Note=1 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 19_23 | 154 | 214 | Repeat | Note=2 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 24_28 | 154 | 214 | Repeat | Note=3 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 29_33 | 154 | 214 | Repeat | Note=4 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 34_38 | 154 | 214 | Repeat | Note=5 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 39_43 | 154 | 214 | Repeat | Note=6 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 44_48 | 154 | 214 | Repeat | Note=7 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 49_53 | 154 | 214 | Repeat | Note=8 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 14_18 | 113 | 173 | Repeat | Note=1 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 19_23 | 113 | 173 | Repeat | Note=2 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 24_28 | 113 | 173 | Repeat | Note=3 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 29_33 | 113 | 173 | Repeat | Note=4 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 34_38 | 113 | 173 | Repeat | Note=5 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 39_43 | 113 | 173 | Repeat | Note=6 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 44_48 | 113 | 173 | Repeat | Note=7 |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 49_53 | 113 | 173 | Repeat | Note=8 |
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FusionGeneSequence for STIM1_VHL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_106aa MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAVTTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDL >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_106aa MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAVTTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDL >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_106aa MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAVTTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDL >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_106aa MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAVTTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_318nt ATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAG GCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGC CTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTG >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_318nt ATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAG GCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGC CTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTG >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_318nt ATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAG GCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGC CTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTG >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_318nt ATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAG GCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGC CTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_3142nt GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGA AAGAGCGATGCCTCCAGGTTGTCCGGAGCCTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGG AAGACCACCCAAATGTGCAGAAAGACCTGGAGCGGCTGACACAGGAGCGCATTGCACATCAACGGATGGGAGATTGAAGATTTCTGTTGA AACTTACACTGTTTCATCTCAGCTTTTGATGGTACTGATGAGTCTTGATCTAGATACAGGACTGGTTCCTTCCTTAGTTTCAAAGTGTCT CATTCTCAGAGTAAAATAGGCACCATTGCTTAAAAGAAAGTTAACTGACTTCACTAGGCATTGTGATGTTTAGGGGCAAACATCACAAAA TGTAATTTAATGCCTGCCCATTAGAGAAGTATTTATCAGGAGAAGGTGGTGGCATTTTTGCTTCCTAGTAAGTCAGGACAGCTTGTATGT AAGGAGGTTTGTATAAGTAATTCAGTGGGAATTGCAGCATATCGTTTAATTTTAAGAAGGCATTGGCATCTGCTTTTAATGGATGTATAA TACATCCATTCTACATCCGTAGCGGTTGGTGACTTGTCTGCCTCCTGCTTTGGGAAGACTGAGGCATCCGTGAGGCAGGGACAAGTCTTT CTCCTCTTTGAGACCCCAGTGCCTGCACATCATGAGCCTTCAGTCAGGGTTTGTCAGAGGAACAAACCAGGGGACACTTTGTTAGAAAGT GCTTAGAGGTTCTGCCTCTATTTTTGTTGGGGGGTGGGAGAGGGGACCTTAAAATGTGTACAGTGAACAAATGTCTTAAAGGGAATCATT TTTGTAGGAAGCATTTTTTATAATTTTCTAAGTCGTGCACTTTCTCGGTCCACTCTTGTTGAAGTGCTGTTTTATTACTGTTTCTAAACT AGGATTGACATTCTACAGTTGTGATAATAGCATTTTTGTAACTTGCCATCCGCACAGAAAATACGAGAAAATCTGCATGTTTGATTATAG TATTAATGGACAAATAAGTTTTTGCTAAATGTGAGTATTTCTGTTCCTTTTTGTAAATATGTGACATTCCTGATTGATTTGGGTTTTTTT GTTGTTGTTGTTTTGTTTTGTTTTGTTTTTTTGAGATGGAGTCTCACTCTTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCA CTGCAACCTCTGCCTCCTGGGTTCACGTAATCCTCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCTGGCCAATTTTTGTACTTT TAGTAGAGACAGTGTTTCGTCATGTTGGCCAGGCTGGTTTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGGTG GGATTACAGGTGTGTGGGCCACCGTGCCTGGCTGATTCAGCATTTTTTATCAGGCAGGACCAGGTGGCACTTCCACCTCCAGCCTCTGGT CCTACCAATGGATTCATGGAGTAGCCTGGACTGTTTCATAGTTTTCTAAATGTACAAATTCTTATAGGCTAGACTTAGATTCATTAACTC AAATTCAATGCTTCTATCAGACTCAGTTTTTTGTAACTAATAGATTTTTTTTTCCACTTTTGTTCTACTCCTTCCCTAATAGCTTTTTAA AAAAATCTCCCCAGTAGAGAAACATTTGGAAAAGACAGAAAACTAAAAAGGAAGAAAAAAGATCCCTATTAGATACACTTCTTAAATACA ATCACATTAACATTTTGAGCTATTTCCTTCCAGCCTTTTTAGGGCAGATTTTGGTTGGTTTTTACATAGTTGAGATTGTACTGTTCATAC AGTTTTATACCCTTTTTCATTTAACTTTATAACTTAAATATTGCTCTATGTTAGTATAAGCTTTTCACAAACATTAGTATAGTCTCCCTT TTATAATTAATGTTTGTGGGTATTTCTTGGCATGCATCTTTAATTCCTTATCCTAGCCTTTGGGCACAATTCCTGTGCTCAAAAATGAGA GTGACGGCTGGCATGGTGGCTCCCGCCTGTAATCCCAGTACTTTGGAAAGCCAAGGTAAGAGGATTGCTTGAGCCCAGAACTTCAAGATG AGCCTGGGCTCATAGTGAGAACCCATCTATACAAAAAATTTTTAAAAATTAGCATGGCGGCACACATCTGTAATCCTAGCTACTTGGCAG GCTGAGGTGAGAAGATCATTGGAGTTTAGGAATTGGAGGCTGCAGTGAGCCATGAGTATGCCACTGCACTCCAGCCTGGGGGACAGAGCA AGACCCTGCCTCAAAAAAAAAAAAAAAAAAAAAATCAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGT >In-frame_STIM1_ENST00000300737_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_3004nt GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGA AAGAGCGATGCCTCCAGGTTGTCCGGAGCCTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGG AAGACCACCCAAATGTGCAGAAAGACCTGGAGCGGCTGACACAGGAGCGCATTGCACATCAACGGATGGGAGATTGAAGATTTCTGTTGA AACTTACACTGTTTCATCTCAGCTTTTGATGGTACTGATGAGTCTTGATCTAGATACAGGACTGGTTCCTTCCTTAGTTTCAAAGTGTCT CATTCTCAGAGTAAAATAGGCACCATTGCTTAAAAGAAAGTTAACTGACTTCACTAGGCATTGTGATGTTTAGGGGCAAACATCACAAAA TGTAATTTAATGCCTGCCCATTAGAGAAGTATTTATCAGGAGAAGGTGGTGGCATTTTTGCTTCCTAGTAAGTCAGGACAGCTTGTATGT AAGGAGGTTTGTATAAGTAATTCAGTGGGAATTGCAGCATATCGTTTAATTTTAAGAAGGCATTGGCATCTGCTTTTAATGGATGTATAA TACATCCATTCTACATCCGTAGCGGTTGGTGACTTGTCTGCCTCCTGCTTTGGGAAGACTGAGGCATCCGTGAGGCAGGGACAAGTCTTT CTCCTCTTTGAGACCCCAGTGCCTGCACATCATGAGCCTTCAGTCAGGGTTTGTCAGAGGAACAAACCAGGGGACACTTTGTTAGAAAGT GCTTAGAGGTTCTGCCTCTATTTTTGTTGGGGGGTGGGAGAGGGGACCTTAAAATGTGTACAGTGAACAAATGTCTTAAAGGGAATCATT TTTGTAGGAAGCATTTTTTATAATTTTCTAAGTCGTGCACTTTCTCGGTCCACTCTTGTTGAAGTGCTGTTTTATTACTGTTTCTAAACT AGGATTGACATTCTACAGTTGTGATAATAGCATTTTTGTAACTTGCCATCCGCACAGAAAATACGAGAAAATCTGCATGTTTGATTATAG TATTAATGGACAAATAAGTTTTTGCTAAATGTGAGTATTTCTGTTCCTTTTTGTAAATATGTGACATTCCTGATTGATTTGGGTTTTTTT GTTGTTGTTGTTTTGTTTTGTTTTGTTTTTTTGAGATGGAGTCTCACTCTTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCA CTGCAACCTCTGCCTCCTGGGTTCACGTAATCCTCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCTGGCCAATTTTTGTACTTT TAGTAGAGACAGTGTTTCGTCATGTTGGCCAGGCTGGTTTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGGTG GGATTACAGGTGTGTGGGCCACCGTGCCTGGCTGATTCAGCATTTTTTATCAGGCAGGACCAGGTGGCACTTCCACCTCCAGCCTCTGGT CCTACCAATGGATTCATGGAGTAGCCTGGACTGTTTCATAGTTTTCTAAATGTACAAATTCTTATAGGCTAGACTTAGATTCATTAACTC AAATTCAATGCTTCTATCAGACTCAGTTTTTTGTAACTAATAGATTTTTTTTTCCACTTTTGTTCTACTCCTTCCCTAATAGCTTTTTAA AAAAATCTCCCCAGTAGAGAAACATTTGGAAAAGACAGAAAACTAAAAAGGAAGAAAAAAGATCCCTATTAGATACACTTCTTAAATACA ATCACATTAACATTTTGAGCTATTTCCTTCCAGCCTTTTTAGGGCAGATTTTGGTTGGTTTTTACATAGTTGAGATTGTACTGTTCATAC AGTTTTATACCCTTTTTCATTTAACTTTATAACTTAAATATTGCTCTATGTTAGTATAAGCTTTTCACAAACATTAGTATAGTCTCCCTT TTATAATTAATGTTTGTGGGTATTTCTTGGCATGCATCTTTAATTCCTTATCCTAGCCTTTGGGCACAATTCCTGTGCTCAAAAATGAGA GTGACGGCTGGCATGGTGGCTCCCGCCTGTAATCCCAGTACTTTGGAAAGCCAAGGTAAGAGGATTGCTTGAGCCCAGAACTTCAAGATG AGCCTGGGCTCATAGTGAGAACCCATCTATACAAAAAATTTTTAAAAATTAGCATGGCGGCACACATCTGTAATCCTAGCTACTTGGCAG GCTGAGGTGAGAAGATCATTGGAGTTTAGGAATTGGAGGCTGCAGTGAGCCATGAGTATGCCACTGCACTCCAGCCTGGGGGACAGAGCA >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000256474_chr3_10191471_+_2662nt GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGCC TAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTGG AGCGGCTGACACAGGAGCGCATTGCACATCAACGGATGGGAGATTGAAGATTTCTGTTGAAACTTACACTGTTTCATCTCAGCTTTTGAT GGTACTGATGAGTCTTGATCTAGATACAGGACTGGTTCCTTCCTTAGTTTCAAAGTGTCTCATTCTCAGAGTAAAATAGGCACCATTGCT TAAAAGAAAGTTAACTGACTTCACTAGGCATTGTGATGTTTAGGGGCAAACATCACAAAATGTAATTTAATGCCTGCCCATTAGAGAAGT ATTTATCAGGAGAAGGTGGTGGCATTTTTGCTTCCTAGTAAGTCAGGACAGCTTGTATGTAAGGAGGTTTGTATAAGTAATTCAGTGGGA ATTGCAGCATATCGTTTAATTTTAAGAAGGCATTGGCATCTGCTTTTAATGGATGTATAATACATCCATTCTACATCCGTAGCGGTTGGT GACTTGTCTGCCTCCTGCTTTGGGAAGACTGAGGCATCCGTGAGGCAGGGACAAGTCTTTCTCCTCTTTGAGACCCCAGTGCCTGCACAT CATGAGCCTTCAGTCAGGGTTTGTCAGAGGAACAAACCAGGGGACACTTTGTTAGAAAGTGCTTAGAGGTTCTGCCTCTATTTTTGTTGG GGGGTGGGAGAGGGGACCTTAAAATGTGTACAGTGAACAAATGTCTTAAAGGGAATCATTTTTGTAGGAAGCATTTTTTATAATTTTCTA AGTCGTGCACTTTCTCGGTCCACTCTTGTTGAAGTGCTGTTTTATTACTGTTTCTAAACTAGGATTGACATTCTACAGTTGTGATAATAG CATTTTTGTAACTTGCCATCCGCACAGAAAATACGAGAAAATCTGCATGTTTGATTATAGTATTAATGGACAAATAAGTTTTTGCTAAAT GTGAGTATTTCTGTTCCTTTTTGTAAATATGTGACATTCCTGATTGATTTGGGTTTTTTTGTTGTTGTTGTTTTGTTTTGTTTTGTTTTT TTGAGATGGAGTCTCACTCTTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCACGTAA TCCTCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCTGGCCAATTTTTGTACTTTTAGTAGAGACAGTGTTTCGTCATGTTGGCC AGGCTGGTTTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGGTGGGATTACAGGTGTGTGGGCCACCGTGCCTG GCTGATTCAGCATTTTTTATCAGGCAGGACCAGGTGGCACTTCCACCTCCAGCCTCTGGTCCTACCAATGGATTCATGGAGTAGCCTGGA CTGTTTCATAGTTTTCTAAATGTACAAATTCTTATAGGCTAGACTTAGATTCATTAACTCAAATTCAATGCTTCTATCAGACTCAGTTTT TTGTAACTAATAGATTTTTTTTTCCACTTTTGTTCTACTCCTTCCCTAATAGCTTTTTAAAAAAATCTCCCCAGTAGAGAAACATTTGGA AAAGACAGAAAACTAAAAAGGAAGAAAAAAGATCCCTATTAGATACACTTCTTAAATACAATCACATTAACATTTTGAGCTATTTCCTTC CAGCCTTTTTAGGGCAGATTTTGGTTGGTTTTTACATAGTTGAGATTGTACTGTTCATACAGTTTTATACCCTTTTTCATTTAACTTTAT AACTTAAATATTGCTCTATGTTAGTATAAGCTTTTCACAAACATTAGTATAGTCTCCCTTTTATAATTAATGTTTGTGGGTATTTCTTGG CATGCATCTTTAATTCCTTATCCTAGCCTTTGGGCACAATTCCTGTGCTCAAAAATGAGAGTGACGGCTGGCATGGTGGCTCCCGCCTGT AATCCCAGTACTTTGGAAAGCCAAGGTAAGAGGATTGCTTGAGCCCAGAACTTCAAGATGAGCCTGGGCTCATAGTGAGAACCCATCTAT ACAAAAAATTTTTAAAAATTAGCATGGCGGCACACATCTGTAATCCTAGCTACTTGGCAGGCTGAGGTGAGAAGATCATTGGAGTTTAGG AATTGGAGGCTGCAGTGAGCCATGAGTATGCCACTGCACTCCAGCCTGGGGGACAGAGCAAGACCCTGCCTCAAAAAAAAAAAAAAAAAA AAAATCAGGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCGAG >In-frame_STIM1_ENST00000527651_chr11_3877639_+_VHL_ENST00000345392_chr3_10191471_+_2524nt GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGTGTATACTCTGAAAGAGCGATGCCTCCAGGTTGTCCGGAGCC TAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTGG AGCGGCTGACACAGGAGCGCATTGCACATCAACGGATGGGAGATTGAAGATTTCTGTTGAAACTTACACTGTTTCATCTCAGCTTTTGAT GGTACTGATGAGTCTTGATCTAGATACAGGACTGGTTCCTTCCTTAGTTTCAAAGTGTCTCATTCTCAGAGTAAAATAGGCACCATTGCT TAAAAGAAAGTTAACTGACTTCACTAGGCATTGTGATGTTTAGGGGCAAACATCACAAAATGTAATTTAATGCCTGCCCATTAGAGAAGT ATTTATCAGGAGAAGGTGGTGGCATTTTTGCTTCCTAGTAAGTCAGGACAGCTTGTATGTAAGGAGGTTTGTATAAGTAATTCAGTGGGA ATTGCAGCATATCGTTTAATTTTAAGAAGGCATTGGCATCTGCTTTTAATGGATGTATAATACATCCATTCTACATCCGTAGCGGTTGGT GACTTGTCTGCCTCCTGCTTTGGGAAGACTGAGGCATCCGTGAGGCAGGGACAAGTCTTTCTCCTCTTTGAGACCCCAGTGCCTGCACAT CATGAGCCTTCAGTCAGGGTTTGTCAGAGGAACAAACCAGGGGACACTTTGTTAGAAAGTGCTTAGAGGTTCTGCCTCTATTTTTGTTGG GGGGTGGGAGAGGGGACCTTAAAATGTGTACAGTGAACAAATGTCTTAAAGGGAATCATTTTTGTAGGAAGCATTTTTTATAATTTTCTA AGTCGTGCACTTTCTCGGTCCACTCTTGTTGAAGTGCTGTTTTATTACTGTTTCTAAACTAGGATTGACATTCTACAGTTGTGATAATAG CATTTTTGTAACTTGCCATCCGCACAGAAAATACGAGAAAATCTGCATGTTTGATTATAGTATTAATGGACAAATAAGTTTTTGCTAAAT GTGAGTATTTCTGTTCCTTTTTGTAAATATGTGACATTCCTGATTGATTTGGGTTTTTTTGTTGTTGTTGTTTTGTTTTGTTTTGTTTTT TTGAGATGGAGTCTCACTCTTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCACGTAA TCCTCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCTGGCCAATTTTTGTACTTTTAGTAGAGACAGTGTTTCGTCATGTTGGCC AGGCTGGTTTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAATGGTGGGATTACAGGTGTGTGGGCCACCGTGCCTG GCTGATTCAGCATTTTTTATCAGGCAGGACCAGGTGGCACTTCCACCTCCAGCCTCTGGTCCTACCAATGGATTCATGGAGTAGCCTGGA CTGTTTCATAGTTTTCTAAATGTACAAATTCTTATAGGCTAGACTTAGATTCATTAACTCAAATTCAATGCTTCTATCAGACTCAGTTTT TTGTAACTAATAGATTTTTTTTTCCACTTTTGTTCTACTCCTTCCCTAATAGCTTTTTAAAAAAATCTCCCCAGTAGAGAAACATTTGGA AAAGACAGAAAACTAAAAAGGAAGAAAAAAGATCCCTATTAGATACACTTCTTAAATACAATCACATTAACATTTTGAGCTATTTCCTTC CAGCCTTTTTAGGGCAGATTTTGGTTGGTTTTTACATAGTTGAGATTGTACTGTTCATACAGTTTTATACCCTTTTTCATTTAACTTTAT AACTTAAATATTGCTCTATGTTAGTATAAGCTTTTCACAAACATTAGTATAGTCTCCCTTTTATAATTAATGTTTGTGGGTATTTCTTGG CATGCATCTTTAATTCCTTATCCTAGCCTTTGGGCACAATTCCTGTGCTCAAAAATGAGAGTGACGGCTGGCATGGTGGCTCCCGCCTGT AATCCCAGTACTTTGGAAAGCCAAGGTAAGAGGATTGCTTGAGCCCAGAACTTCAAGATGAGCCTGGGCTCATAGTGAGAACCCATCTAT ACAAAAAATTTTTAAAAATTAGCATGGCGGCACACATCTGTAATCCTAGCTACTTGGCAGGCTGAGGTGAGAAGATCATTGGAGTTTAGG AATTGGAGGCTGCAGTGAGCCATGAGTATGCCACTGCACTCCAGCCTGGGGGACAGAGCAAGACCCTGCCTCAAAAAAAAAAAAAAAAAA |
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FusionGenePPI for STIM1_VHL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STIM1 | STIM2, PRKAA2, SEPT11, S100A16, SEC22B, CAT, SF1, MAPRE1, HLA-DRA, METTL6, GABRE, IFNA14, HEXB, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, CDH1, PTPRN2, CCDC40, HAUS1, LRRTM1, IL17RB, SLC39A9, CD1E, EXOC5 | VHL | FLNA, VBP1, JADE1, CUL2, CAB39, TGFB1I1, STK16, PFAS, TCEB1, PSMB1, TCEB2, RHOC, CNTF, TXN, APRT, CDK2, PKD1L3, FSCN1, IARS, PSMB3, RASGRP1, RAB1B, RBX1, NEDD8, TAGLN2, MOB4, CCDC59, JMJD1C, CDO1, PAPSS2, HIST1H2BC, CCDC82, PSMD13, TARS, TPT1, RPA3, KNTC1, MCC, PCMT1, CSTB, CSTF3, HAS1, RPS9, IMPDH2, ATXN2, CHMP2B, MYL12A, PPIB, PIN1, PSMC3, HIF1A, ZNF197, TRIM28, HIF1AN, HDAC1, HDAC2, HDAC3, FN1, CUL5, HNRNPA2B1, USP33, RIT1, NR4A1, POLR2A, SAP130, EPAS1, OSR1, DGKZ, SAT2, CYBA, DNAJA3, IREB2, TP53, EP300, KAT2B, ATM, USP20, TCEB3, POLR2G, HIF3A, CCT3, MCM7, PRKCI, DVL2, MYBBP1A, UBXN7, ADRB2, SPRY2, ANKRD40, CDKN2A, STUB1, CMC2, DDX17, DDX3X, DDX3Y, DDX5, DNAJA1, DNAJA2, EPHA4, GRWD1, COLGALT1, HNRNPDL, HNRNPH1, HNRNPH2, HNRNPLL, HNRNPC, HNRNPD, HNRNPL, HNRNPM, HNRNPR, EIF5A, EIF5A2, NKRF, RALYL, RBBP4, RBBP7, RPL12, RPL14, RPL18A, HNRNPA3, RPS11, RPS14, RPS17, RPS27L, RPS27, RPS2, RPS3A, RPS3, RPSA, SNRNP70, TUBA1A, TUBA3C, TUBA3E, TUBA4A, TCP1, CCT2, CCT4, CCT5, CCT7, CCT8, CCT6A, TRAFD1, UBR5, PRMT3, ACTB, BSG, COL4A1, COL4A2, COL4A3, COL4A5, COL4A6, COL6A1, CRTAP, FASTKD3, GRN, HNRNPK, HNRNPU, HSPA8, MIF, IVNS1ABP, P3H1, PARP1, PLOD2, PLOD3, PPM1B, RPL10A, RPL30, RPL7A, RPLP0, HNRNPA1, HNRNPAB, RPS15A, RPS5, STK38, TUBA3D, TUBB4B, VHL, XRCC5, SKP2, CLU, ELAVL1, MYC, PIAS4, TOP2A, CBX5, BCL2L11, CSNK2A1, PRKCD, JAK2, SOCS1, SOCS3, LIMD1, EGLN1, AJUBA, WTIP, LPP, ZYX, COPS5, GNB2L1, PRKCH, PRKCZ, DGKI, KIF2C, SARNP, CAPN7, YY1AP1, RBPMS2, RB1CC1, FKBP8, PTPN14, EXOSC8, KIF3A, KIF3B, KIFAP3, HSPA1A, PARD6A, PARD3, KLF4, SP1, CARD9, RNF7, MKNK2, UBE2D1, ALAS1, CDC34, APP, DCUN1D1, TGM2, FZR1, PCGF2, ZNF512B, CHEK2, KAT5, RPS6, NOB1, RPL11, LTV1, PRMT1, MSH4, UXT, AR, SON, EEF1B2, RPL21, RBPMS, VAPB, NCL, SLC2A1, CD44, SLC3A2, HIST4H4, CBR1, HIST1H1C, CAPZB, HIST1H2BL, LANCL1, HSPA5, PRDX1, RPL5, CBX1, CBX3, PRMT8, ILF3, PDCD5, PARK7, AURKA, GLI1, E2F1, SIRT1, HSPA4, HSP90AA1, MDFI, PLD1, UBC, UBE2D2, C1QB, C1QTNF2, CER1, KIRREL2, BCL2L14, COL9A1, KNG1, ASTL, RWDD3, GOLGA4, TRIP12, ZNF350, ID2, ID1, ID3, PLD2, TARDBP, GPLD1, CERKL, EPOR, DACT1, DACT2, RHOBTB3, UBE2S, HUWE1, USP9X, SMURF1, MAP3K1, PRKDC, CDK4, TSC1, CHEK1, APC, CDKN1B, KDM5C, ARID2, PTEN, PDGFRA, BRAF, RRM2, ARID1A, MAP2K1, PIK3R1, FGFR3, SMARCB1, CDK6, ROR1, CASP8, PBRM1, RPS6KB1, FLT3, VEGFA, SQSTM1, CEP68, ATF7IP, SETDB1, ARL14EP, OXT, AVP, CHIT1, INHBE, C1QL4, UTRN, ACTBL2, FAM19A3, AKT1, AKT2, PPP2CA, FASN, CAD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000256474 | + | 1 | 3 | 157_166 | 154 | 214 | Elongin BC complex |
| Tgene | VHL | chr11:3877639 | chr3:10191471 | ENST00000345392 | + | 0 | 2 | 157_166 | 113 | 173 | Elongin BC complex |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STIM1_VHL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STIM1_VHL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STIM1 | C1861451 | Stormorken Syndrome | 4 | ORPHANET;UNIPROT |
| Hgene | STIM1 | C4011726 | MYOPATHY, TUBULAR AGGREGATE, 1 | 4 | UNIPROT |
| Hgene | STIM1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | STIM1 | C2748557 | Immune dysfunction with T-cell inactivation due to calcium entry defect 2 | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | STIM1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | VHL | C0019562 | Von Hippel-Lindau Syndrome | 17 | CTD_human;ORPHANET;UNIPROT |
| Tgene | VHL | C0007134 | Renal Cell Carcinoma | 9 | CTD_human;HPO |
| Tgene | VHL | C0031511 | Pheochromocytoma | 9 | CTD_human;HPO;UNIPROT |
| Tgene | VHL | C1837915 | ERYTHROCYTOSIS, FAMILIAL, 2 | 5 | CTD_human;ORPHANET;UNIPROT |
| Tgene | VHL | C0001430 | Adenoma | 1 | CTD_human |
| Tgene | VHL | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | VHL | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | VHL | C0027708 | Nephroblastoma | 1 | CTD_human |
| Tgene | VHL | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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