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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36428

FusionGeneSummary for STAU2_PLEKHF2

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU2_PLEKHF2
Fusion gene ID: 36428
HgeneTgene
Gene symbol

STAU2

PLEKHF2

Gene ID

27067

79666

Gene namestaufen double-stranded RNA binding protein 2pleckstrin homology and FYVE domain containing 2
Synonyms39K2|39K3EAPF|PHAFIN2|ZFYVE18
Cytomap

8q21.11

8q22.1

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2pleckstrin homology domain-containing family F member 2PH and FYVE domain-containing protein 2PH domain-containing family F member 2endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domainspleckstrin homology domain co
Modification date2018051920180523
UniProtAcc

Q9NUL3

Q9H8W4

Ensembl transtripts involved in fusion geneENST00000522695, ENST00000524300, 
ENST00000523558, ENST00000521210, 
ENST00000355780, ENST00000519961, 
ENST00000521727, ENST00000521451, 
ENST00000522509, ENST00000517542, 
ENST00000524104, ENST00000522962, 
ENST00000521419, 		ENST00000315367, 
ENST00000519516, 
Fusion gene scores* DoF score11 X 8 X 9=7922 X 1 X 2=4
# samples 132
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: STAU2 [Title/Abstract] AND PLEKHF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-F5-6813-01ASTAU2chr8

74585342

-PLEKHF2chr8

96166259

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000522695ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000522695ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000524300ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000524300ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
intron-5UTRENST00000523558ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
intron-5UTRENST00000523558ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521210ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521210ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000355780ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000355780ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000519961ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000519961ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521727ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521727ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
intron-5UTRENST00000521451ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
intron-5UTRENST00000521451ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000522509ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000522509ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000517542ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000517542ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000524104ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000524104ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5UTR-5UTRENST00000522962ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5UTR-5UTRENST00000522962ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521419ENST00000315367STAU2chr8

74585342

-PLEKHF2chr8

96166259

+
5CDS-5UTRENST00000521419ENST00000519516STAU2chr8

74585342

-PLEKHF2chr8

96166259

+

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FusionProtFeatures for STAU2_PLEKHF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAU2

Q9NUL3

PLEKHF2

Q9H8W4

May play a role in early endosome fusion upstream ofRAB5, hence regulating receptor trafficking and fluid-phasetransport. Enhances cellular sensitivity to TNF-induced apoptosis(PubMed:18288467). {ECO:0000269|PubMed:18288467,ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAU2_PLEKHF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAU2_PLEKHF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAU2KIAA1377, DHX58, EIF2AK2, ELAVL1, COPS5, DICER1, PRKRA, UPF1, ZNF346, ADAR, SHMT2, MOV10, NXF1, BMI1, HIST1H1A, RPL14, RPL8, RPL6, NIFK, RPS2, PRR11, RBM4B, ILF2, PAIP1, HNRNPU, MATR3, STRBP, STAU1, GLTSCR2, WDR46, ELAVL2, PPAN, ZCRB1, ZC3HAV1, E4F1, DGCR8, ZNF324B, NXF2, CDX1, RPL37A, ZNF169, HIST1H1E, RPF1, ZNF2, GPATCH4, G3BP1PLEKHF2BLOC1S6, SFN, GNMT, RTN4, GLUL, SPEF1, GPBP1L1, NONO, RTN1, RTN3, RABAC1, TSC22D3, MBIP, PRKAR1A, UBE2Z, SDPR, CCDC85B, ZNF263, PRPSAP1, MAX, CHIC2, ELAVL1, APP, DUT, MEAF6, BEND7, APPL1, LDOC1, FHL3, GFER, SEPT2, S100A1, S100A13, TRAF6, AIMP2, NPM2, SEPT6, FBXO28, TNFAIP8, SETBP1, BSCL2, TRAPPC3, HSPB7, TXNL4B, ZNF398, ZNF250, GPBP1, CEP44, FRMD8, L3MBTL3, ACY3, DTX2, RSPO2, SHMT2, MOV10, DRAP1, ARL14EP, CCDC172, SEPT5, CXorf57, DPPA4, PRDM14, AIDA, TBX3, USF1, CGGBP1, THOC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAU2_PLEKHF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAU2_PLEKHF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAU2C0023893Liver Cirrhosis, Experimental1CTD_human