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Fusion gene ID: 36408 |
FusionGeneSummary for STATH_CLDN10 |
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Fusion gene information | Fusion gene name: STATH_CLDN10 | Fusion gene ID: 36408 | Hgene | Tgene | Gene symbol | STATH | CLDN10 | Gene ID | 6779 | 9071 |
Gene name | statherin | claudin 10 | |
Synonyms | STR | CPETRL3|HELIX|OSP-L|OSPL | |
Cytomap | 4q13.3 | 13q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | statherin | claudin-10OSP-like proteinoligodendrocyte-specific protein-like | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P02808 | P78369 | |
Ensembl transtripts involved in fusion gene | ENST00000246895, ENST00000381060, | ENST00000376873, ENST00000299339, ENST00000376855, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 2 X 5=40 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STATH [Title/Abstract] AND CLDN10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP333889 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000246895 | ENST00000376873 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
3UTR-intron | ENST00000246895 | ENST00000299339 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
3UTR-intron | ENST00000246895 | ENST00000376855 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
3UTR-intron | ENST00000381060 | ENST00000376873 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
3UTR-intron | ENST00000381060 | ENST00000299339 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
3UTR-intron | ENST00000381060 | ENST00000376855 | STATH | chr4 | 70868094 | + | CLDN10 | chr13 | 96103568 | - |
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FusionProtFeatures for STATH_CLDN10 |
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Hgene | Tgene |
STATH | CLDN10 |
Salivary protein that stabilizes saliva supersaturatedwith calcium salts by inhibiting the precipitation of calciumphosphate salts. It also modulates hydroxyapatite crystalformation on the tooth surface. | Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation ofparacellular epithelia permeability to ions in multiple organs. Itacts as a paracellular ion channel probably forming permselectivepores; isoform 1 appears to create pores preferentially permeableto cations and isoform 2 for anions. In sweat glands and in thethick ascending limb (TAL) of Henle's loop in kidney, it controlsparacellular sodium permeability which is essential for propersweat production and renal function (PubMed:19383724,PubMed:28771254, PubMed:28686597). {ECO:0000269|PubMed:19383724,ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STATH_CLDN10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STATH_CLDN10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STATH_CLDN10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STATH_CLDN10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STATH | C0004352 | Autistic Disorder | 1 | CTD_human |