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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36408

FusionGeneSummary for STATH_CLDN10

check button Fusion gene summary
Fusion gene informationFusion gene name: STATH_CLDN10
Fusion gene ID: 36408
HgeneTgene
Gene symbol

STATH

CLDN10

Gene ID

6779

9071

Gene namestatherinclaudin 10
SynonymsSTRCPETRL3|HELIX|OSP-L|OSPL
Cytomap

4q13.3

13q32.1

Type of geneprotein-codingprotein-coding
Descriptionstatherinclaudin-10OSP-like proteinoligodendrocyte-specific protein-like
Modification date2018051920180519
UniProtAcc

P02808

P78369

Ensembl transtripts involved in fusion geneENST00000246895, ENST00000381060, 
ENST00000376873, ENST00000299339, 
ENST00000376855, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 2 X 5=40
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STATH [Title/Abstract] AND CLDN10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP333889STATHchr4

70868094

+CLDN10chr13

96103568

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000246895ENST00000376873STATHchr4

70868094

+CLDN10chr13

96103568

-
3UTR-intronENST00000246895ENST00000299339STATHchr4

70868094

+CLDN10chr13

96103568

-
3UTR-intronENST00000246895ENST00000376855STATHchr4

70868094

+CLDN10chr13

96103568

-
3UTR-intronENST00000381060ENST00000376873STATHchr4

70868094

+CLDN10chr13

96103568

-
3UTR-intronENST00000381060ENST00000299339STATHchr4

70868094

+CLDN10chr13

96103568

-
3UTR-intronENST00000381060ENST00000376855STATHchr4

70868094

+CLDN10chr13

96103568

-

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FusionProtFeatures for STATH_CLDN10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STATH

P02808

CLDN10

P78369

Salivary protein that stabilizes saliva supersaturatedwith calcium salts by inhibiting the precipitation of calciumphosphate salts. It also modulates hydroxyapatite crystalformation on the tooth surface. Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation ofparacellular epithelia permeability to ions in multiple organs. Itacts as a paracellular ion channel probably forming permselectivepores; isoform 1 appears to create pores preferentially permeableto cations and isoform 2 for anions. In sweat glands and in thethick ascending limb (TAL) of Henle's loop in kidney, it controlsparacellular sodium permeability which is essential for propersweat production and renal function (PubMed:19383724,PubMed:28771254, PubMed:28686597). {ECO:0000269|PubMed:19383724,ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STATH_CLDN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STATH_CLDN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STATH_CLDN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STATH_CLDN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTATHC0004352Autistic Disorder1CTD_human