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Fusion gene ID: 36403 |
FusionGeneSummary for STAT6_PALLD |
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Fusion gene information | Fusion gene name: STAT6_PALLD | Fusion gene ID: 36403 | Hgene | Tgene | Gene symbol | STAT6 | PALLD | Gene ID | 6778 | 23022 |
Gene name | signal transducer and activator of transcription 6 | palladin, cytoskeletal associated protein | |
Synonyms | D12S1644|IL-4-STAT|STAT6B|STAT6C | CGI-151|CGI151|MYN|PNCA1|SIH002 | |
Cytomap | 12q13.3 | 4q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | signal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT | palladinmyoneurinsarcoma antigen NY-SAR-77 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P42226 | Q8WX93 | |
Ensembl transtripts involved in fusion gene | ENST00000300134, ENST00000538913, ENST00000543873, ENST00000556155, ENST00000537215, ENST00000454075, | ENST00000335742, ENST00000261509, ENST00000505667, ENST00000333488, ENST00000512127, ENST00000507735, | |
Fusion gene scores | * DoF score | 6 X 9 X 2=108 | 7 X 6 X 3=126 |
# samples | 9 | 7 | |
** MAII score | log2(9/108*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STAT6 [Title/Abstract] AND PALLD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STAT6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8810328 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG953466 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000300134 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000300134 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000300134 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000300134 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000300134 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000300134 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000538913 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000538913 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000538913 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000538913 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000538913 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000538913 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000543873 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000543873 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000543873 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000543873 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000543873 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000543873 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000556155 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000556155 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000556155 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000556155 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000556155 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000556155 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000537215 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000537215 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000537215 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000537215 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000537215 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000537215 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000454075 | ENST00000335742 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000454075 | ENST00000261509 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000454075 | ENST00000505667 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000454075 | ENST00000333488 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-intron | ENST00000454075 | ENST00000512127 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
intron-3UTR | ENST00000454075 | ENST00000507735 | STAT6 | chr12 | 57489821 | + | PALLD | chr4 | 169848998 | - |
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FusionProtFeatures for STAT6_PALLD |
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Hgene | Tgene |
STAT6 | PALLD |
Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STAT6_PALLD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STAT6_PALLD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STAT6_PALLD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAT6_PALLD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STAT6 | C1266119 | Solitary fibrous tumor | 2 | CTD_human |
Hgene | STAT6 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Hgene | STAT6 | C0013604 | Edema | 1 | CTD_human |
Hgene | STAT6 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Tgene | PALLD | C0043094 | Weight Gain | 1 | CTD_human |