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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36403

FusionGeneSummary for STAT6_PALLD

check button Fusion gene summary
Fusion gene informationFusion gene name: STAT6_PALLD
Fusion gene ID: 36403
HgeneTgene
Gene symbol

STAT6

PALLD

Gene ID

6778

23022

Gene namesignal transducer and activator of transcription 6palladin, cytoskeletal associated protein
SynonymsD12S1644|IL-4-STAT|STAT6B|STAT6CCGI-151|CGI151|MYN|PNCA1|SIH002
Cytomap

12q13.3

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionsignal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STATpalladinmyoneurinsarcoma antigen NY-SAR-77
Modification date2018051920180523
UniProtAcc

P42226

Q8WX93

Ensembl transtripts involved in fusion geneENST00000300134, ENST00000538913, 
ENST00000543873, ENST00000556155, 
ENST00000537215, ENST00000454075, 
ENST00000335742, ENST00000261509, 
ENST00000505667, ENST00000333488, 
ENST00000512127, ENST00000507735, 
Fusion gene scores* DoF score6 X 9 X 2=1087 X 6 X 3=126
# samples 97
** MAII scorelog2(9/108*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAT6 [Title/Abstract] AND PALLD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTAT6

GO:0045944

positive regulation of transcription by RNA polymerase II

8810328


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG953466STAT6chr12

57489821

+PALLDchr4

169848998

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000300134ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000300134ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000300134ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000300134ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000300134ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000300134ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000538913ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000538913ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000538913ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000538913ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000538913ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000538913ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000543873ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000543873ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000543873ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000543873ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000543873ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000543873ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000556155ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000556155ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000556155ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000556155ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000556155ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000556155ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000537215ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000537215ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000537215ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000537215ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000537215ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000537215ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000454075ENST00000335742STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000454075ENST00000261509STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000454075ENST00000505667STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000454075ENST00000333488STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-intronENST00000454075ENST00000512127STAT6chr12

57489821

+PALLDchr4

169848998

-
intron-3UTRENST00000454075ENST00000507735STAT6chr12

57489821

+PALLDchr4

169848998

-

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FusionProtFeatures for STAT6_PALLD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAT6

P42226

PALLD

Q8WX93

Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAT6_PALLD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAT6_PALLD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAT6_PALLD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAT6_PALLD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAT6C1266119Solitary fibrous tumor2CTD_human
HgeneSTAT6C0011615Dermatitis, Atopic1CTD_human
HgeneSTAT6C0013604Edema1CTD_human
HgeneSTAT6C0018671Head and Neck Neoplasms1CTD_human
TgenePALLDC0043094Weight Gain1CTD_human