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Fusion gene ID: 36383 |
FusionGeneSummary for STAT3_ETV4 |
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Fusion gene information | Fusion gene name: STAT3_ETV4 | Fusion gene ID: 36383 | Hgene | Tgene | Gene symbol | STAT3 | ETV4 | Gene ID | 6774 | 2118 |
Gene name | signal transducer and activator of transcription 3 | ETS variant 4 | |
Synonyms | ADMIO|ADMIO1|APRF|HIES | E1A-F|E1AF|PEA3|PEAS3 | |
Cytomap | 17q21.2 | 17q21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor | ETS translocation variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P40763 | P43268 | |
Ensembl transtripts involved in fusion gene | ENST00000264657, ENST00000585517, ENST00000389272, ENST00000588969, ENST00000404395, ENST00000590776, | ENST00000319349, ENST00000393664, ENST00000538265, ENST00000545954, ENST00000545089, ENST00000591713, ENST00000586826, | |
Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 9 X 8 X 3=216 |
# samples | 8 | 18 | |
** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/216*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STAT3 [Title/Abstract] AND ETV4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STAT3 | GO:0006355 | regulation of transcription, DNA-templated | 15664994|17344214 |
Hgene | STAT3 | GO:0006606 | protein import into nucleus | 18234692 |
Hgene | STAT3 | GO:0010628 | positive regulation of gene expression | 23820254 |
Hgene | STAT3 | GO:0030522 | intracellular receptor signaling pathway | 17324931 |
Hgene | STAT3 | GO:0032355 | response to estradiol | 12552091 |
Hgene | STAT3 | GO:0032870 | cellular response to hormone stimulus | 12552091 |
Hgene | STAT3 | GO:0033210 | leptin-mediated signaling pathway | 17344214 |
Hgene | STAT3 | GO:0035278 | miRNA mediated inhibition of translation | 23820254 |
Hgene | STAT3 | GO:0044320 | cellular response to leptin stimulus | 17344214 |
Hgene | STAT3 | GO:0044321 | response to leptin | 17344214 |
Hgene | STAT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19390056 |
Hgene | STAT3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17324931 |
Hgene | STAT3 | GO:0051726 | regulation of cell cycle | 17344214 |
Hgene | STAT3 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
Hgene | STAT3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
Hgene | STAT3 | GO:0070102 | interleukin-6-mediated signaling pathway | 12359225|12552091|17324931 |
Hgene | STAT3 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19390056|23820254 |
Hgene | STAT3 | GO:2000637 | positive regulation of gene silencing by miRNA | 23820254 |
Tgene | ETV4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 24983502 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5511-01A | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264657 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000264657 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000264657 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000264657 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000264657 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000264657 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
5CDS-intron | ENST00000264657 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-3CDS | ENST00000585517 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
3UTR-intron | ENST00000585517 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000389272 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
5CDS-intron | ENST00000389272 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000588969 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
5CDS-intron | ENST00000588969 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
Frame-shift | ENST00000404395 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
5CDS-intron | ENST00000404395 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000319349 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000393664 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000538265 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000545954 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000545089 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-3CDS | ENST00000590776 | ENST00000591713 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
intron-intron | ENST00000590776 | ENST00000586826 | STAT3 | chr17 | 40468807 | - | ETV4 | chr17 | 41611353 | - |
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FusionProtFeatures for STAT3_ETV4 |
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Hgene | Tgene |
STAT3 | ETV4 |
Signal transducer and transcription activator thatmediates cellular responses to interleukins, KITLG/SCF, LEP andother growth factors (PubMed:10688651, PubMed:12359225,PubMed:12873986, PubMed:15194700, PubMed:17344214,PubMed:18242580, PubMed:23084476). Once activated, recruitscoactivators, such as NCOA1 or MED1, to the promoter region of thetarget gene (PubMed:17344214). May mediate cellular responses toactivated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Bindsto the interleukin-6 (IL-6)-responsive elements identified in thepromoters of various acute-phase protein genes (PubMed:12359225).Activated by IL31 through IL31RA (PubMed:15194700). Acts as aregulator of inflammatory response by regulating differentiationof naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells(Treg): deacetylation and oxidation of lysine residues by LOXL3,leads to disrupt STAT3 dimerization and inhibit its transcriptionactivity (PubMed:28065600). Involved in cell cycle regulation byinducing the expression of key genes for the progression from G1to S phase, such as CCND1 (PubMed:17344214). Mediates the effectsof LEP on melanocortin production, body energy homeostasis andlactation (By similarity). May play an apoptotic role bytransctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy byinhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucialrole in basal beta cell functions, such as regulation of insulinsecretion (By similarity). {ECO:0000250|UniProtKB:P42227,ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225,ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700,ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580,ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600}. | Transcriptional activator that binds to the enhancer ofthe adenovirus E1A gene; the core-binding sequence is5'[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:19307308}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STAT3_ETV4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STAT3_ETV4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STAT3 | RPA2, RET, EGFR, EPHA5, JAK1, TRIP10, AR, NR3C1, MYOD1, NDUFA13, KAT5, CREBBP, EP300, SMAD1, STAT1, PTPN11, IL1RAP, IL2RB, FES, NCOA1, ESR1, PIAS3, PTPN2, CCND1, HSP90AA1, KHDRBS1, ERBB2, MTOR, ELP2, PML, PTK2, JUN, IFNAR1, TSHR, HNF1A, IL6ST, PDIA3, NFKB1, RELA, IL6R, NMI, EIF2AK2, RAC1, SRC, BMX, GTF2I, CDKN1A, GHR, CCR5, JAK2, HIF1A, MET, CTR9, ALK, HOXC11, STAT6, SS18L1, PCBD2, SP1, BCL3, PELP1, DNMT1, HDAC1, RB1, HDAC2, HDAC3, STAT3, NFKBIZ, CEBPB, SMARCA4, CDK9, FGFR1, FGFR2, PPP2R1B, TIRAP, PRKCD, MAPK8, PGR, SIRT1, SETD7, KDM1A, RUNX2, ELAVL1, BHLHE40, CD44, DAXX, SOCS7, IRAK1, MAP3K7, MAPK1, FHL2, TRAF6, ZFHX3, APEX1, PTPN1, JAK3, TRIM28, HCK, LYN, FYN, FGR, HES1, HES5, SIN3A, BICD1, ECH1, SRI, SULT2A1, MRPS31, BCKDK, CORO1A, GNL3, OGDHL, NR4A1, CAPN1, MORC4, RPS9, HIVEP1, ASXL1, RPL11, NIF3L1, SUPT20H, HLA-A, AMBP, CAPNS1, LAMB2, HNRNPM, SIAH1, SIAH2, SCAF11, MAP3K13, SPRY1, SSSCA1, ZFPM2, ARFIP2, SRRT, ERBB2IP, IL22RA1, CEP120, LUC7L2, PSMG3, ARFIP1, IVNS1ABP, MSH2, PUS7, TBC1D15, TBCD, BRD4, ADRB2, COPS5, HIC1, USP22, GNB2, GADD45A, BLK, LMO2, SYK, SHMT2, MOV10, NXF1, NFKB2, AZU1, CACNG2, NXPH2, DDX19B, RP2, TRPV5, TCEAL1, IDE, NTRK1, BRWD1, FAM208B, CCDC87, DOK2, DOK3, FAM117B, GSTCD, HESX1, KRTAP10-7, MAPKAPK2, MPZL1, NUFIP2, PAQR7, PIK3R3, RABGAP1, SH2D2A, TM4SF19, TWIST1, VPS39, WDFY3, ZNF281, ZNF829, ABL2, CA8, CBL, DTNA, LASP1, LCK, PIK3R1, PIK3R2, PPARD, SH3BP2, BATF3, CHTF18, CNDP2, KLF15, NACAD, NXT2, OFCC1, PINK1, TDG, ZNF557, ATF3, MNDA, PAFAH1B2, IGF1R, PDGFRA, PDGFRB, STAT5B, ANKRD26P1, KIF27, PLA2G4A, LRRFIP2, HSP90B1, RRAD, FBXW7, STMN1, MAGEC2, RFWD2, CREB1, RELB, CDK15, LRRC32, IL20RA, TBC1D22B, TMEM206, MBLAC2, VASN, C3AR1, PVR, DLK2, ANXA2, TRIM25, TES | ETV4 | HOXD4, RFWD2, SAE1, UBA2, SMAD2, APP, HTT, ATXN1, STK11, TP63, JUN, CARM1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STAT3_ETV4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAT3_ETV4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STAT3 | C3489795 | Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant | 4 | CTD_human;ORPHANET;UNIPROT |
Hgene | STAT3 | C0018800 | Cardiomegaly | 3 | CTD_human |
Hgene | STAT3 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
Hgene | STAT3 | C0001418 | Adenocarcinoma | 2 | CTD_human |
Hgene | STAT3 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
Hgene | STAT3 | C0009324 | Ulcerative Colitis | 2 | CTD_human |
Hgene | STAT3 | C0021368 | Inflammation | 2 | CTD_human |
Hgene | STAT3 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Hgene | STAT3 | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
Hgene | STAT3 | C0878544 | Cardiomyopathies | 2 | CTD_human |
Hgene | STAT3 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | STAT3 | C0004364 | Autoimmune Diseases | 1 | CTD_human;HPO |
Hgene | STAT3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | STAT3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | STAT3 | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | STAT3 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
Hgene | STAT3 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | STAT3 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | STAT3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
Hgene | STAT3 | C0015967 | Fever | 1 | CTD_human |
Hgene | STAT3 | C0016059 | Fibrosis | 1 | CTD_human |
Hgene | STAT3 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
Hgene | STAT3 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | STAT3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Hgene | STAT3 | C0023492 | Leukemia, T-Cell | 1 | CTD_human |
Hgene | STAT3 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Hgene | STAT3 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | STAT3 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Hgene | STAT3 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | STAT3 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | STAT3 | C0025149 | Medulloblastoma | 1 | CTD_human |
Hgene | STAT3 | C0025261 | Memory Disorders | 1 | CTD_human |
Hgene | STAT3 | C0033860 | Psoriasis | 1 | CTD_human |
Hgene | STAT3 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | STAT3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | STAT3 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Hgene | STAT3 | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | CTD_human |
Hgene | STAT3 | C0235833 | Congenital diaphragmatic hernia | 1 | CTD_human |
Hgene | STAT3 | C0333641 | Atrophic | 1 | CTD_human |
Hgene | STAT3 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | STAT3 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | STAT3 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Hgene | STAT3 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Hgene | STAT3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | STAT3 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
Hgene | STAT3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Hgene | STAT3 | C3887645 | Job Syndrome | 1 | CTD_human |
Hgene | STAT3 | C4014795 | AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET | 1 | ORPHANET;UNIPROT |
Tgene | ETV4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ETV4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ETV4 | C1458155 | Mammary Neoplasms | 1 | CTD_human |