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Fusion gene ID: 3638 |
FusionGeneSummary for AVEN_GOLGA8B |
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Fusion gene information | Fusion gene name: AVEN_GOLGA8B | Fusion gene ID: 3638 | Hgene | Tgene | Gene symbol | AVEN | GOLGA8B | Gene ID | 57099 | 440270 |
Gene name | apoptosis and caspase activation inhibitor | golgin A8 family member B | |
Synonyms | PDCD12 | GOLGA5 | |
Cytomap | 15q14 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | cell death regulator Avenapoptosis, caspase activation inhibitorprogrammed cell death 12 | golgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NQS1 | A8MQT2 | |
Ensembl transtripts involved in fusion gene | ENST00000306730, ENST00000558136, | ENST00000267731, ENST00000569811, ENST00000342314, ENST00000438958, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 3 X 3=36 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AVEN [Title/Abstract] AND GOLGA8B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AVEN | GO:0043066 | negative regulation of apoptotic process | 10949025 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-95-7043-01A | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000306730 | ENST00000267731 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
5CDS-intron | ENST00000306730 | ENST00000569811 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
5CDS-intron | ENST00000306730 | ENST00000342314 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
5CDS-intron | ENST00000306730 | ENST00000438958 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
intron-5UTR | ENST00000558136 | ENST00000267731 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
intron-intron | ENST00000558136 | ENST00000569811 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
intron-intron | ENST00000558136 | ENST00000342314 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
intron-intron | ENST00000558136 | ENST00000438958 | AVEN | chr15 | 34295233 | - | GOLGA8B | chr15 | 34846157 | - |
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FusionProtFeatures for AVEN_GOLGA8B |
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Hgene | Tgene |
AVEN | GOLGA8B |
Protects against apoptosis mediated by Apaf-1. | May be involved in maintaining Golgi structure.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AVEN_GOLGA8B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AVEN_GOLGA8B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AVEN | BCL2L1, BCL2, APAF1, MOV10, NXF1, XPO1, HNRNPU, RPL10 | GOLGA8B | CDH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AVEN_GOLGA8B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AVEN_GOLGA8B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AVEN | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |