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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36368

FusionGeneSummary for STARD7_SEL1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: STARD7_SEL1L3
Fusion gene ID: 36368
HgeneTgene
Gene symbol

STARD7

SEL1L3

Gene ID

56910

23231

Gene nameStAR related lipid transfer domain containing 7SEL1L family member 3
SynonymsGTT1Sel-1L3
Cytomap

2q11.2

4p15.2

Type of geneprotein-codingprotein-coding
DescriptionstAR-related lipid transfer protein 7, mitochondrialSTART domain containing 7START domain-containing protein 7StAR-related lipid transfer (START) domain containing 7gestational trophoblastic tumor protein 1protein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3
Modification date2018052320180519
UniProtAcc

Q9NQZ5

Q68CR1

Ensembl transtripts involved in fusion geneENST00000337288, ENST00000462501, 
ENST00000399878, ENST00000264868, 
ENST00000502949, ENST00000513364, 
Fusion gene scores* DoF score7 X 7 X 3=1472 X 2 X 2=8
# samples 72
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: STARD7 [Title/Abstract] AND SEL1L3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI765503STARD7chr2

96850861

-SEL1L3chr4

25749118

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000337288ENST00000399878STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-3UTRENST00000337288ENST00000264868STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-intronENST00000337288ENST00000502949STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-intronENST00000337288ENST00000513364STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-3UTRENST00000462501ENST00000399878STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-3UTRENST00000462501ENST00000264868STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-intronENST00000462501ENST00000502949STARD7chr2

96850861

-SEL1L3chr4

25749118

-
intron-intronENST00000462501ENST00000513364STARD7chr2

96850861

-SEL1L3chr4

25749118

-

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FusionProtFeatures for STARD7_SEL1L3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STARD7

Q9NQZ5

SEL1L3

Q68CR1

May play a protective role in mucosal tissues bypreventing exaggerated allergic responses.{ECO:0000250|UniProtKB:Q8R1R3}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STARD7_SEL1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STARD7_SEL1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STARD7_SEL1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STARD7_SEL1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource