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Fusion gene ID: 36337 |
FusionGeneSummary for STARD13_TNFRSF8 |
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Fusion gene information | Fusion gene name: STARD13_TNFRSF8 | Fusion gene ID: 36337 | Hgene | Tgene | Gene symbol | STARD13 | TNFRSF8 | Gene ID | 90627 | 943 |
Gene name | StAR related lipid transfer domain containing 13 | TNF receptor superfamily member 8 | |
Synonyms | ARHGAP37|DLC2|GT650|LINC00464 | CD30|D1S166E|Ki-1 | |
Cytomap | 13q13.1-q13.2 | 1p36.22 | |
Type of gene | protein-coding | protein-coding | |
Description | stAR-related lipid transfer protein 13Rho GTPase activating protein on chromosome 13q12StAR-related lipid transfer (START) domain containing 13deleted in liver cancer 2 proteinlong intergenic non-protein coding RNA 464 | tumor necrosis factor receptor superfamily member 8CD30L receptorKi-1 antigencytokine receptor CD30lymphocyte activation antigen CD30 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9Y3M8 | P28908 | |
Ensembl transtripts involved in fusion gene | ENST00000336934, ENST00000255486, ENST00000399365, ENST00000487412, ENST00000439831, | ENST00000263932, ENST00000417814, ENST00000413146, ENST00000479933, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 3 X 4 X 3=36 |
# samples | 6 | 3 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STARD13 [Title/Abstract] AND TNFRSF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TNFRSF8 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 16108830 |
Tgene | TNFRSF8 | GO:0043065 | positive regulation of apoptotic process | 16108830 |
Tgene | TNFRSF8 | GO:0045556 | positive regulation of TRAIL biosynthetic process | 16108830 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0C7-01B | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000336934 | ENST00000263932 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
Frame-shift | ENST00000336934 | ENST00000417814 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5CDS-intron | ENST00000336934 | ENST00000413146 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5CDS-intron | ENST00000336934 | ENST00000479933 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000255486 | ENST00000263932 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000255486 | ENST00000417814 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000255486 | ENST00000413146 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000255486 | ENST00000479933 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000399365 | ENST00000263932 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000399365 | ENST00000417814 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000399365 | ENST00000413146 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000399365 | ENST00000479933 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5UTR-3CDS | ENST00000487412 | ENST00000263932 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5UTR-3CDS | ENST00000487412 | ENST00000417814 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5UTR-intron | ENST00000487412 | ENST00000413146 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
5UTR-intron | ENST00000487412 | ENST00000479933 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000439831 | ENST00000263932 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-3CDS | ENST00000439831 | ENST00000417814 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000439831 | ENST00000413146 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
intron-intron | ENST00000439831 | ENST00000479933 | STARD13 | chr13 | 33859607 | - | TNFRSF8 | chr1 | 12169623 | + |
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FusionProtFeatures for STARD13_TNFRSF8 |
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Hgene | Tgene |
STARD13 | TNFRSF8 |
Receptor for TNFSF8/CD30L. May play a role in theregulation of cellular growth and transformation of activatedlymphoblasts. Regulates gene expression through activation of NF-kappa-B. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STARD13_TNFRSF8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STARD13_TNFRSF8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STARD13 | TUBA1A, KIF1B, HMGCR, EPB41L1, SMARCD3, TAX1BP1, HSP90AA1, ITPR1, BAI2, SMAD1, S100A7, SERPINB4, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, RTKN, SH3PXD2A, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, DENND4C, NF1, HDAC4, CBY1, CDC25C, INPP5E | TNFRSF8 | TNFSF8, TDP2, TRAF5, TRAF2, TRAIP, BCL6, TRAF1, TRAF3, TNFRSF8, NAA25, CCDC112, NAA20, CEP57, DPY19L1, DAPK3, SPATS2, BLOC1S1, EXOC1, ATP6V1D, GOLPH3L, RACGAP1, FHL2, KIF3A, NDC1, CDC6, GOLPH3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STARD13_TNFRSF8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TNFRSF8 | P28908 | DB08870 | Brentuximab vedotin | Tumor necrosis factor receptor superfamily member 8 {ECO:0000312|HGNC:HGNC:11923} | biotech | approved|investigational |
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RelatedDiseases for STARD13_TNFRSF8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | STARD13 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | TNFRSF8 | C0019829 | Hodgkin Disease | 2 | CTD_human |
Tgene | TNFRSF8 | C0345967 | Malignant mesothelioma | 1 | CTD_human |