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Fusion gene ID: 36321 |
FusionGeneSummary for STAM2_THSD7B |
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Fusion gene information | Fusion gene name: STAM2_THSD7B | Fusion gene ID: 36321 | Hgene | Tgene | Gene symbol | STAM2 | THSD7B | Gene ID | 10254 | 80731 |
Gene name | signal transducing adaptor molecule 2 | thrombospondin type 1 domain containing 7B | |
Synonyms | Hbp|STAM2A|STAM2B | - | |
Cytomap | 2q23.3 | 2q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | signal transducing adapter molecule 2HSE1 homologHrs-binding proteinSTAM-2STAM-like protein containing SH3 and ITAM domains 2signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | thrombospondin type-1 domain-containing protein 7Bthrombospondin, type I, domain containing 7B | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | O75886 | Q9C0I4 | |
Ensembl transtripts involved in fusion gene | ENST00000263904, ENST00000465460, | ENST00000409968, ENST00000272643, ENST00000413152, ENST00000543459, ENST00000485379, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 3=36 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STAM2 [Title/Abstract] AND THSD7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0C7-01B | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263904 | ENST00000409968 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
Frame-shift | ENST00000263904 | ENST00000272643 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
Frame-shift | ENST00000263904 | ENST00000413152 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
5CDS-intron | ENST00000263904 | ENST00000543459 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
5CDS-intron | ENST00000263904 | ENST00000485379 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
intron-3CDS | ENST00000465460 | ENST00000409968 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
intron-3CDS | ENST00000465460 | ENST00000272643 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
intron-3CDS | ENST00000465460 | ENST00000413152 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
intron-intron | ENST00000465460 | ENST00000543459 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
intron-intron | ENST00000465460 | ENST00000485379 | STAM2 | chr2 | 152982740 | - | THSD7B | chr2 | 137813990 | + |
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FusionProtFeatures for STAM2_THSD7B |
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Hgene | Tgene |
STAM2 | THSD7B |
Involved in intracellular signal transduction mediatedby cytokines and growth factors. Upon IL-2 and GM-CSL stimulation,it plays a role in signaling leading to DNA synthesis and MYCinduction. May also play a role in T-cell development. Involved indown-regulation of receptor tyrosine kinase via multivesicularbody (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0complex binds ubiquitin and acts as sorting machinery thatrecognizes ubiquitinated receptors and transfers them to furthersequential lysosomal sorting/trafficking processes (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STAM2_THSD7B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STAM2_THSD7B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STAM2 | DAZAP2, L3MBTL2, HGS, STAMBP, USP8, JAK1, EPS15, JAK2, JAK3, TYK2, UBE2D1, UBE2D2, UBE2D3, UBE2H, CBX5, UBC, ITCH, SEC31A, SEC13, UBQLN1, RIN1, EGFR, STAM, UBQLN4, PTPN1, NAPA, KRT8, RNF11, ZFYVE9, ATXN1, PTPN23, PHF10, XRN1, KIF15, SF3A3, ACTN1, DCAF8, SRP19, VCP, TIMM8A, LCP2, FAM189A2, LITAF, ABI2, PLEKHB2, VPS37C, KLHL42, ARRDC3, SH2D4A, MAP3K1, COG7, PPP1R13B, TP53BP2, TSG101, TP53, OFD1, FBF1, TMEM17, TMEM216, XPO1, PTPRN2, TPTE | THSD7B | RANBP10 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STAM2_THSD7B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAM2_THSD7B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | THSD7B | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |