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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36311

FusionGeneSummary for STAG2_PAK3

check button Fusion gene summary
Fusion gene informationFusion gene name: STAG2_PAK3
Fusion gene ID: 36311
HgeneTgene
Gene symbol

STAG2

PAK3

Gene ID

10735

8874

Gene namestromal antigen 2Rho guanine nucleotide exchange factor 7
SynonymsSA-2|SA2|SCC3B|bA517O1.1BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB
Cytomap

Xq25

13q34

Type of geneprotein-codingprotein-coding
Descriptioncohesin subunit SA-2SCC3 homolog 2rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein
Modification date2018052220180522
UniProtAcc

Q8N3U4

O75914

Ensembl transtripts involved in fusion geneENST00000218089, ENST00000469481, 
ENST00000354548, ENST00000371160, 
ENST00000371157, ENST00000371145, 
ENST00000371144, 
ENST00000425146, 
ENST00000446737, ENST00000372010, 
ENST00000519681, ENST00000372007, 
ENST00000518291, ENST00000484442, 
ENST00000262836, ENST00000360648, 
ENST00000417227, 
Fusion gene scores* DoF score9 X 11 X 6=5943 X 3 X 2=18
# samples 133
** MAII scorelog2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STAG2 [Title/Abstract] AND PAK3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAK3

GO:0043547

positive regulation of GTPase activity

21048939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-76-4926-01BSTAG2chrX

123191827

+PAK3chrX

110257056

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218089ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000218089ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000218089ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-5UTRENST00000469481ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
intron-intronENST00000469481ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000354548ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000354548ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000371160ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371160ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000371157ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371157ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000371145ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371145ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000425146STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-5UTRENST00000371144ENST00000446737STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000372010STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000519681STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000372007STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000518291STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000484442STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000262836STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000360648STAG2chrX

123191827

+PAK3chrX

110257056

+
5CDS-intronENST00000371144ENST00000417227STAG2chrX

123191827

+PAK3chrX

110257056

+

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FusionProtFeatures for STAG2_PAK3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAG2

Q8N3U4

PAK3

O75914

Component of cohesin complex, a complex required for thecohesion of sister chromatids after DNA replication. The cohesincomplex apparently forms a large proteinaceous ring within whichsister chromatids can be trapped. At anaphase, the complex iscleaved and dissociates from chromatin, allowing sister chromatidsto segregate. The cohesin complex may also play a role in spindlepole assembly during mitosis. {ECO:0000269|PubMed:12034751}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAG2_PAK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAG2_PAK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAG2PDS5A, SRRM1, SSU72, RAD21, SMC1A, SMC3, PDS5B, WFDC5, WAPAL, SIRT7, NSMCE2, PLK1, SFPQ, SRRM2, RBM14, NHP2L1, VCP, CDCA5, HDAC8, OBSL1, COMTD1, VSIG2, GPR183, PNKD, ALDH3A2, PIP5K1A, BZW2, COPE, EXOSC2, EXOSC9, SMC1B, KDM2A, NTRK1, FOXB1, USP37, CDC5L, SIGLECL1, CD70, CCDC102B, GYPB, CD83, OPRM1PAK3RAC1, ARHGEF7, SNCA, CDC42, ITSN1, PAK3, ABCE1, SNRNP27, MAPK14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STAG2_PAK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAG2_PAK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAG2C0005695Bladder Neoplasm3CTD_human
HgeneSTAG2C0007138Carcinoma, Transitional Cell1CTD_human
HgeneSTAG2C0023470Myeloid Leukemia1CTD_human
HgeneSTAG2C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgenePAK3C0796237Mental Retardation, X-Linked 302CTD_human;UNIPROT