FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36267

FusionGeneSummary for ST7L_AP2A2

check button Fusion gene summary
Fusion gene informationFusion gene name: ST7L_AP2A2
Fusion gene ID: 36267
HgeneTgene
Gene symbol

ST7L

AP2A2

Gene ID

54879

161

Gene namesuppression of tumorigenicity 7 likeadaptor related protein complex 2 subunit alpha 2
SynonymsFAM4B|ST7R|STLRADTAB|CLAPA2|HIP-9|HIP9|HYPJ
Cytomap

1p13.2

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionsuppressor of tumorigenicity 7 protein-likeST7-related proteintumor suppressor ST7 likeAP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin as
Modification date2018051920180522
UniProtAcc

Q8TDW4

O94973

Ensembl transtripts involved in fusion geneENST00000360743, ENST00000358039, 
ENST00000544629, ENST00000369669, 
ENST00000490067, ENST00000369668, 
ENST00000369666, ENST00000343210, 
ENST00000538187, ENST00000463235, 
ENST00000543570, 		ENST00000534328, 
ENST00000332231, ENST00000448903, 
ENST00000525891, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 3=48
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST7L [Title/Abstract] AND AP2A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-E6-A8L9-01AST7Lchr1

113161531

-AP2A2chr11

1009100

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360743ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000360743ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000360743ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000360743ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000358039ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000358039ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000358039ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000358039ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000544629ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000544629ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000544629ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000544629ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000369669ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000369669ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000369669ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-3UTRENST00000369669ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000490067ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000490067ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000490067ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000490067ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369668ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369668ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369668ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000369668ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369666ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369666ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000369666ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000369666ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000343210ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000343210ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000343210ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000343210ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000538187ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000538187ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000538187ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-3UTRENST00000538187ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000463235ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000463235ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-intronENST00000463235ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
intron-3UTRENST00000463235ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000543570ENST00000534328ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000543570ENST00000332231ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-intronENST00000543570ENST00000448903ST7Lchr1

113161531

-AP2A2chr11

1009100

+
5CDS-3UTRENST00000543570ENST00000525891ST7Lchr1

113161531

-AP2A2chr11

1009100

+

Top

FusionProtFeatures for ST7L_AP2A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST7L

Q8TDW4

AP2A2

O94973

Component of the adaptor protein complex 2 (AP-2).Adaptor protein complexes function in protein transport viatransport vesicles in different membrane traffic pathways. Adaptorprotein complexes are vesicle coat components and appear to beinvolved in cargo selection and vesicle formation. AP-2 isinvolved in clathrin-dependent endocytosis in which cargo proteinsare incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with theearly endosome. The clathrin lattice serves as a mechanicalscaffold but is itself unable to bind directly to membranecomponents. Clathrin-associated adaptor protein (AP) complexeswhich can bind directly to both the clathrin lattice and to thelipid and protein components of membranes are considered to be themajor clathrin adaptors contributing the CCV formation. AP-2 alsoserves as a cargo receptor to selectively sort the membraneproteins involved in receptor-mediated endocytosis. AP-2 seems toplay a role in the recycling of synaptic vesicle membranes fromthe presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi)and [ED]-X-X-X-L-[LI] endocytosis signal motifs within thecytosolic tails of transmembrane cargo molecules. AP-2 may alsoplay a role in maintaining normal post-endocytic traffickingthrough the ARF6-regulated, non-clathrin pathway. The AP-2 alphasubunit binds polyphosphoinositide-containing lipids, positioningAP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocyticaccessory proteins. The AP-2 alpha and AP-2 sigma subunits arethought to contribute to the recognition of the [ED]-X-X-X-L-[LI]motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147,ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838,ECO:0000269|PubMed:19033387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ST7L_AP2A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ST7L_AP2A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST7LMCOLN3, ZNRF4, FAM189B, PCDHB11, CHRND, KCNS3, SLC17A2, PCDHGB4, PCDHB7, GABRD, RNF170, RNF185, IL17RB, LRRN2, TNFRSF10A, SLC4A8, GABRA6, SLC39A8, KIR3DL2AP2A2HTT, DAB2, EPS15, SHC1, AMPH, CLTC, EPN1, TERF2, ARRB2, BIN1, GRB2, GRK5, AP2M1, APP, AP2A1, VCP, FN1, SMAD1, PAN2, EGFR, PPP6R3, RPA3, RPA2, RPA1, PIP5K1C, ATP1A1, MOV10, NXF1, NECAP2, LRFN4, AAGAB, ZBTB46, NTRK1, AP1B1, AP2S1, NAPA, NUTF2, AP2B1, EIF2B1, CLTB, DBN1, GAK, KIF11, IQGAP1, FAN1, LIMA1, GTSE1, YBX1, MCM2, ESR1, MEX3C, RNF126, NLGN3, DIEXF, MYO6, MTMR4, RUNDC3A, ARFGAP1, SNX9, GPBP1L1, GPR156, CLINT1, FCHO1, REPS1, LSR, CPSF4L, INTS4, UBC, OCRL, SLC2A8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ST7L_AP2A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ST7L_AP2A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource