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Fusion gene ID: 36262 |
FusionGeneSummary for ST6GALNAC3_AK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST6GALNAC3_AK5 | Fusion gene ID: 36262 | Hgene | Tgene | Gene symbol | ST6GALNAC3 | AK5 | Gene ID | 256435 | 26289 |
| Gene name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | adenylate kinase 5 | |
| Synonyms | PRO7177|SIAT7C|ST6GALNACIII|STY | AK6 | |
| Cytomap | 1p31.1 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) | adenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NDV1 | Q9Y6K8 | |
| Ensembl transtripts involved in fusion gene | ENST00000328299, ENST00000464140, | ENST00000354567, ENST00000344720, ENST00000317704, ENST00000478255, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 3 X 4=60 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST6GALNAC3 [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ST6GALNAC3 | GO:0006677 | glycosylceramide metabolic process | 17123352 |
| Hgene | ST6GALNAC3 | GO:0006687 | glycosphingolipid metabolic process | 17123352 |
| Hgene | ST6GALNAC3 | GO:0009100 | glycoprotein metabolic process | 17123352 |
| Tgene | AK5 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Tgene | AK5 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-LA-A7SW-01A | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328299 | ENST00000354567 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000328299 | ENST00000344720 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000328299 | ENST00000317704 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000328299 | ENST00000478255 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000464140 | ENST00000354567 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000464140 | ENST00000344720 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000464140 | ENST00000317704 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000464140 | ENST00000478255 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
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FusionProtFeatures for ST6GALNAC3_AK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST6GALNAC3 | AK5 |
| Involved in the biosynthesis of ganglioside GD1A fromGM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAcresidue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteinsand glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins(By similarity). {ECO:0000250}. | Nucleoside monophosphate (NMP) kinase that catalyzes thereversible transfer of the terminal phosphate group betweennucleoside triphosphates and monophosphates. Active on AMP anddAMP with ATP as a donor. When GTP is used as phosphate donor, theenzyme phosphorylates AMP, CMP, and to a small extent dCMP. Alsodisplays broad nucleoside diphosphate kinase activity.{ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ST6GALNAC3 | chr1:76540569 | chr1:77949002 | ENST00000328299 | + | 1 | 5 | 1_8 | 6 | 306 | Topological domain | Cytoplasmic |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 386_391 | 327 | 537 | Nucleotide binding | ATP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 433_435 | 327 | 537 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 462_465 | 327 | 537 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 386_391 | 353 | 563 | Nucleotide binding | ATP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 433_435 | 353 | 563 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 462_465 | 353 | 563 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 377_559 | 327 | 537 | Region | Adenylate kinase 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 406_435 | 327 | 537 | Region | NMPbind 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 499_509 | 327 | 537 | Region | LID 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 377_559 | 353 | 563 | Region | Adenylate kinase 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 406_435 | 353 | 563 | Region | NMPbind 2 |
| Tgene | >AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 499_509 | 353 | 563 | Region | LID 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ST6GALNAC3 | chr1:76540569 | chr1:77949002 | ENST00000328299 | + | 1 | 5 | 29_305 | 6 | 306 | Topological domain | Lumenal |
| Hgene | >ST6GALNAC3 | chr1:76540569 | chr1:77949002 | ENST00000328299 | + | 1 | 5 | 9_28 | 6 | 306 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 142_147 | 327 | 537 | Nucleotide binding | ATP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 191_193 | 327 | 537 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 219_222 | 327 | 537 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 142_147 | 353 | 563 | Nucleotide binding | ATP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 191_193 | 353 | 563 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 219_222 | 353 | 563 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 133_316 | 327 | 537 | Region | Adenylate kinase 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 162_193 | 327 | 537 | Region | NMPbind 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 256_266 | 327 | 537 | Region | LID 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 133_316 | 353 | 563 | Region | Adenylate kinase 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 162_193 | 353 | 563 | Region | NMPbind 1 |
| Tgene | AK5 | chr1:76540569 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 256_266 | 353 | 563 | Region | LID 1 |
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FusionGeneSequence for ST6GALNAC3_AK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000354567_chr1_77949002_+_216aa MACILKGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPS GIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIP >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000344720_chr1_77949002_+_216aa MACILKGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPS GIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000354567_chr1_77949002_+_648nt ATGGCCTGCATCCTGAAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAA ATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACT GGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCA GGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTG AAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTT CTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCC GTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCT >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000344720_chr1_77949002_+_648nt ATGGCCTGCATCCTGAAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAA ATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACT GGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCA GGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTG AAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTT CTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCC GTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000354567_chr1_77949002_+_2092nt GCAGCTTACACCGCGGTCCCCTTATTTGGATCTGCGGGAATGTGGGCTGGAGAGGTCCTGCCGTGGTACCAGCCTCCAGCCTGCCCCCAG GACTGCCCCTGACCCAGGCGCGCCCGCTGCTCGGTGGCAGGAGGGCCGGCGGAGCGCCATGGCCTGCATCCTGAAGGGTGATGACCAGTT AAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGG CAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGA ATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCAT GGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGG AGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGA CGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCT ACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCAT GTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCA ACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGG ACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGT CAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAA GCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTT TGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGA GGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCA GTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGT CTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCA TTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAAC AAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCT TGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAG AGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTT TTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAA >In-frame_ST6GALNAC3_ENST00000328299_chr1_76540569_+_AK5_ENST00000344720_chr1_77949002_+_2088nt GCAGCTTACACCGCGGTCCCCTTATTTGGATCTGCGGGAATGTGGGCTGGAGAGGTCCTGCCGTGGTACCAGCCTCCAGCCTGCCCCCAG GACTGCCCCTGACCCAGGCGCGCCCGCTGCTCGGTGGCAGGAGGGCCGGCGGAGCGCCATGGCCTGCATCCTGAAGGGTGATGACCAGTT AAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGG CAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGA ATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCAT GGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGG AGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGA CGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCT ACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCAT GTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCA ACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGG ACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGT CAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAA GCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTT TGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGA GGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCA GTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGT CTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCA TTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAAC AAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCT TGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAG AGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTT TTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAA |
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FusionGenePPI for ST6GALNAC3_AK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ST6GALNAC3 | CAMK1, SAAL1, SELENBP1, PON2, DSG4, PKP3, PTCH1, SCN3B, GGT7, CLEC2D, KLRG2, TMED6, DUSP14, NCEH1 | AK5 | C7orf26, CPNE6, NUCKS1, STRN4, TRIM46, UGDH, RNF114, CEBPA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ST6GALNAC3_AK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST6GALNAC3_AK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AK5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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