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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36247

FusionGeneSummary for ST3GAL5_ST3GAL5

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL5_ST3GAL5
Fusion gene ID: 36247
HgeneTgene
Gene symbol

ST3GAL5

ST3GAL5

Gene ID

8869

8869

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 5ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SynonymsSATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalVSATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalV
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionlactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide allactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al
Modification date2018052320180523
UniProtAcc

Q9UNP4

Q9UNP4

Ensembl transtripts involved in fusion geneENST00000393805, ENST00000377332, 
ENST00000525834, ENST00000484728, 
ENST00000393808, 		ENST00000393805, 
ENST00000377332, ENST00000525834, 
ENST00000484728, ENST00000393808, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/8*10)=1.90689059560852
Context

PubMed: ST3GAL5 [Title/Abstract] AND ST3GAL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF933062ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
ChiTaRS3.1BF933057ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000393805ENST00000393805ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393805ENST00000377332ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393805ENST00000525834ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393805ENST00000484728ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393805ENST00000393808ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000377332ENST00000393805ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000377332ENST00000377332ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000377332ENST00000525834ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000377332ENST00000484728ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000377332ENST00000393808ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000525834ENST00000393805ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000525834ENST00000377332ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000525834ENST00000525834ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000525834ENST00000484728ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000525834ENST00000393808ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000484728ENST00000393805ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000484728ENST00000377332ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000484728ENST00000525834ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000484728ENST00000484728ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000484728ENST00000393808ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393808ENST00000393805ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393808ENST00000377332ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393808ENST00000525834ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393808ENST00000484728ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+
intron-intronENST00000393808ENST00000393808ST3GAL5chr2

86106184

-ST3GAL5chr2

86106439

+

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FusionProtFeatures for ST3GAL5_ST3GAL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST3GAL5

Q9UNP4

ST3GAL5

Q9UNP4

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). {ECO:0000269|PubMed:16934889}. Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). {ECO:0000269|PubMed:16934889}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST3GAL5_ST3GAL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ST3GAL5_ST3GAL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST3GAL5_ST3GAL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ST3GAL5_ST3GAL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource