FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36246

FusionGeneSummary for ST3GAL5_KCMF1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL5_KCMF1
Fusion gene ID: 36246
HgeneTgene
Gene symbol

ST3GAL5

KCMF1

Gene ID

8869

56888

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 5potassium channel modulatory factor 1
SynonymsSATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalVDEBT91|FIGC|PCMF|ZZZ1
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionlactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide alE3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9
Modification date2018052320180519
UniProtAcc

Q9UNP4

Q9P0J7

Ensembl transtripts involved in fusion geneENST00000393805, ENST00000377332, 
ENST00000525834, ENST00000484728, 
ENST00000393808, 
ENST00000409785, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 3=75
# samples 47
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST3GAL5 [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI462676ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393805ENST00000409785ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+
Frame-shitENST00000377332ENST00000409785ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+
Frame-shitENST00000525834ENST00000409785ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+
5UTR-3CDSENST00000484728ENST00000409785ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+
intron-3CDSENST00000393808ENST00000409785ST3GAL5chr2

86115945

-KCMF1chr2

85255010

+

Top

FusionProtFeatures for ST3GAL5_KCMF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST3GAL5

Q9UNP4

KCMF1

Q9P0J7

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). {ECO:0000269|PubMed:16934889}. Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ST3GAL5_KCMF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ST3GAL5_KCMF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST3GAL5TMEM259, NDUFAF7, HLA-DPB1KCMF1GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ST3GAL5_KCMF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ST3GAL5_KCMF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource