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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36233

FusionGeneSummary for ST3GAL3_TAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL3_TAL1
Fusion gene ID: 36233
HgeneTgene
Gene symbol

ST3GAL3

TAL1

Gene ID

6487

6886

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 3TAL bHLH transcription factor 1, erythroid differentiation factor
SynonymsEIEE15|MRT12|SIAT6|ST3GALII|ST3Gal III|ST3GalIII|ST3NSCL|TCL5|bHLHa17|tal-1
Cytomap

1p34.1

1p33

Type of geneprotein-codingprotein-coding
DescriptionCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-siT-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product
Modification date2018052420180523
UniProtAcc

Q11203

P17542

Ensembl transtripts involved in fusion geneENST00000262915, ENST00000372375, 
ENST00000351035, ENST00000372374, 
ENST00000353126, ENST00000545417, 
ENST00000330208, ENST00000335430, 
ENST00000372377, ENST00000361392, 
ENST00000361400, ENST00000347631, 
ENST00000361812, ENST00000372362, 
ENST00000531451, ENST00000372366, 
ENST00000372365, ENST00000372368, 
ENST00000332628, ENST00000372372, 
ENST00000531816, ENST00000528371, 
ENST00000372369, ENST00000531993, 
ENST00000361746, ENST00000533933, 
ENST00000372367, ENST00000461375, 
ENST00000371884, ENST00000371883, 
ENST00000294339, ENST00000459729, 
Fusion gene scores* DoF score9 X 6 X 8=4322 X 2 X 2=8
# samples 92
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ST3GAL3 [Title/Abstract] AND TAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAL1

GO:0031334

positive regulation of protein complex assembly

20855495

TgeneTAL1

GO:0045648

positive regulation of erythrocyte differentiation

20028976

TgeneTAL1

GO:0045893

positive regulation of transcription, DNA-templated

20028976

TgeneTAL1

GO:0045944

positive regulation of transcription by RNA polymerase II

20855495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1FC-01AST3GAL3chr1

44303983

+TAL1chr1

47685846

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000262915ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000262915ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000262915ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000262915ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372375ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372375ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372375ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372375ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000351035ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000351035ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000351035ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000351035ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-5UTRENST00000372374ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000353126ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000353126ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000353126ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000353126ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000545417ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000545417ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000545417ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000545417ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000330208ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000330208ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000330208ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000330208ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000335430ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000335430ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000335430ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000335430ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372377ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372377ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372377ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372377ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361392ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361392ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361392ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361392ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361400ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361400ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361400ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361400ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000347631ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000347631ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000347631ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000347631ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361812ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361812ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361812ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361812ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372362ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372362ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372362ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372362ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531451ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531451ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531451ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531451ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372366ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372366ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372366ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372366ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372365ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372365ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372365ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372365ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372368ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372368ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372368ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372368ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-5UTRENST00000332628ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372372ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372372ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372372ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372372ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531816ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531816ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531816ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531816ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000528371ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000528371ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000528371ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000528371ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372369ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372369ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372369ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372369ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531993ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531993ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000531993ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531993ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361746ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361746ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000361746ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361746ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000533933ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000533933ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000533933ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000533933ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372367ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372367ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shitENST00000372367ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372367ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-5UTRENST00000461375ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-

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FusionProtFeatures for ST3GAL3_TAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST3GAL3

Q11203

TAL1

P17542

Implicated in the genesis of hemopoietic malignancies.It may play an important role in hemopoietic differentiation.Serves as a positive regulator of erythroid differentiation (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST3GAL3_TAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ST3GAL3_TAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST3GAL3ACTG1, SCAMP2, ZBTB5, RPL8TAL1LMO2, NCAPG2, EP300, LMO1, PRKCQ, TCF4, GATA3, TCF3, TCF12, GATA1, SSBP1, SSBP2, SSBP3, CBFA2T3, CBFA2T2, HDAC1, HDAC2, TRRAP, BRD1, RCC1, XRCC6, TOP1, PARP1, LDB1, SP1, GATA2, SIN3A, SKP2, STUB1, TRIM27, SUV39H1, SATB1, TRIM33, TAL1, SUPT16H, CDK9, KDM1A, RCOR1, RBBP7, CHD4, CHD3, RB1, RUNX1, LYL1, ZHX1, DRG1, KAT2B, ELSPBP1, HOXB9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST3GAL3_TAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ST3GAL3_TAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST3GAL3C1970200MENTAL RETARDATION, AUTOSOMAL RECESSIVE 121UNIPROT
HgeneST3GAL3C3554316EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 151UNIPROT
TgeneTAL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human