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Fusion gene ID: 36216 |
FusionGeneSummary for ST14_APLP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST14_APLP2 | Fusion gene ID: 36216 | Hgene | Tgene | Gene symbol | ST14 | APLP2 | Gene ID | 6768 | 334 |
| Gene name | suppression of tumorigenicity 14 | amyloid beta precursor like protein 2 | |
| Synonyms | ARCI11|HAI|MT-SP1|MTSP1|PRSS14|SNC19|TADG15|TMPRSS14 | APLP-2|APPH|APPL2|CDEBP | |
| Cytomap | 11q24.3 | 11q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | suppressor of tumorigenicity 14 proteinmembrane-type serine protease 1prostaminserine protease 14serine protease TADG-15suppression of tumorigenicity 14 (colon carcinoma)suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)tumor a | amyloid-like protein 2CDEI box-binding proteinamyloid beta (A4) precursor-like protein 2amyloid precursor protein homolog HSD-2testicular tissue protein Li 23 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y5Y6 | Q06481 | |
| Ensembl transtripts involved in fusion gene | ENST00000278742, | ENST00000532456, ENST00000539648, ENST00000528499, ENST00000263574, ENST00000345598, ENST00000338167, ENST00000278756, ENST00000543137, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 5 X 8 X 3=120 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST14 [Title/Abstract] AND APLP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ST14 | GO:0006508 | proteolysis | 19911255 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-8265-01A | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| TCGA | RV | UCEC | TCGA-B5-A3S1-01A | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000278742 | ENST00000532456 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000539648 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000528499 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000263574 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000345598 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000338167 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000278756 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-5UTR | ENST00000278742 | ENST00000543137 | ST14 | chr11 | 130029955 | + | APLP2 | chr11 | 129979324 | + |
| 5CDS-intron | ENST00000278742 | ENST00000532456 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000539648 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000528499 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000263574 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000345598 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000338167 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000278756 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
| 5CDS-intron | ENST00000278742 | ENST00000543137 | ST14 | chr11 | 130078579 | + | APLP2 | chr11 | 130010293 | + |
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FusionProtFeatures for ST14_APLP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST14 | APLP2 |
| Degrades extracellular matrix. Proposed to play a rolein breast cancer invasion and metastasis. Exhibits trypsin-likeactivity as defined by cleavage of synthetic substrates with Argor Lys as the P1 site. Involved in the terminal differentiation ofkeratinocytes through prostasin (PRSS8) activation and filaggrin(FLG) processing. {ECO:0000269|PubMed:18843291}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ST14_APLP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ST14_APLP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ST14 | SPINT1, PDGFC, RGS16, AKT1, APC, CASP8, CDKN2C, CHEK2, NOTCH2, PHB, RAD51, STK11, TGFB1 | APLP2 | BRCA1, SFN, DAB2, DAB1, APBB1, APBB3, HGS, JUN, RYK, HDAC5, KAT5, ELAVL1, BAG6, VKORC1, ZNF512B, MAPK8, RPL26, DEDD, ETS1, JUNB, KLK2, APBB2, PTPN1, PTPN2, VAV1, APBA3, FCGRT, DKKL1, NKTR, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ST14_APLP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ST14 | Q9Y5Y6 | DB00013 | Urokinase | Suppressor of tumorigenicity 14 protein | biotech | approved|investigational|withdrawn |
| Tgene | APLP2 | Q06481 | DB01593 | Zinc | Amyloid-like protein 2 | small molecule | approved|investigational |
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RelatedDiseases for ST14_APLP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ST14 | C1835851 | Ichthyosis with hypotrichosis, autosomal recessive | 2 | CTD_human;ORPHANET;UNIPROT |
| Hgene | ST14 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ST14 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ST14 | C0265962 | Ichthyosis linearis circumflexa | 1 | CTD_human |
| Tgene | APLP2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | APLP2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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