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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36211

FusionGeneSummary for SSX2IP_WDPCP

check button Fusion gene summary
Fusion gene informationFusion gene name: SSX2IP_WDPCP
Fusion gene ID: 36211
HgeneTgene
Gene symbol

SSX2IP

WDPCP

Gene ID

117178

51057

Gene nameSSX family member 2 interacting proteinWD repeat containing planar cell polarity effector
SynonymsADIP|hMsd1BBS15|C2orf86|CHDTHP|CPLANE5|FRITZ|FRTZ
Cytomap

1p22.3

2p15

Type of geneprotein-codingprotein-coding
Descriptionafadin- and alpha-actinin-binding proteinSSX2-interacting proteinafadin DIL domain-interacting proteinsynovial sarcoma, X breakpoint 2 interacting proteinWD repeat-containing and planar cell polarity effector protein fritz homologBardet-Biedl syndrome 15 proteinWD repeat-containing protein C2orf86ciliogenesis and planar polarity effector 5
Modification date2018052220180523
UniProtAcc

Q9Y2D8

O95876

Ensembl transtripts involved in fusion geneENST00000437941, ENST00000342203, 
ENST00000605755, ENST00000603677, 
ENST00000370612, 
ENST00000272321, 
ENST00000409199, ENST00000409120, 
ENST00000398544, ENST00000409562, 
ENST00000409835, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 2 X 3=18
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SSX2IP [Title/Abstract] AND WDPCP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-N8-A4PP-01ASSX2IPchr1

85155837

-WDPCPchr2

63938725

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000437941ENST00000272321SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000437941ENST00000409199SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000437941ENST00000409120SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000437941ENST00000398544SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000437941ENST00000409562SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000437941ENST00000409835SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000272321SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000409199SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000409120SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000398544SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000409562SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000342203ENST00000409835SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000272321SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000409199SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000409120SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000398544SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000409562SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000605755ENST00000409835SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000272321SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000409199SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000409120SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000398544SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000409562SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
5UTR-intronENST00000603677ENST00000409835SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000272321SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000409199SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000409120SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000398544SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000409562SSX2IPchr1

85155837

-WDPCPchr2

63938725

-
intron-intronENST00000370612ENST00000409835SSX2IPchr1

85155837

-WDPCPchr2

63938725

-

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FusionProtFeatures for SSX2IP_WDPCP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSX2IP

Q9Y2D8

WDPCP

O95876

Probable effector of the planar cell polarity signalingpathway which regulates the septin cytoskeleton in bothciliogenesis and collective cell movements. Together with FUZ andWDPCP proposed to function as core component of the CPLANE(ciliogenesis and planar polarity effectors) complex involved inthe recruitment of peripheral IFT-A proteins to basal bodies (Bysimilarity). {ECO:0000250|UniProtKB:Q32NR9,ECO:0000250|UniProtKB:Q8C456}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSX2IP_WDPCP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSX2IP_WDPCP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SSX2IPMLLT4, ACTN1, USP11, ELAVL1, CDC42, CCNH, YWHAZ, IKBKG, YWHAQ, LATS2, KDM1A, PRMT6, ARNT2, NDN, CEP250, XIAP, BYSL, DAXX, PHC2, EHHADH, EIF4A2, GEM, KRT15, KRT31, LMO2, MFAP1, MOS, TRIM37, DRG1, PRKAA1, PKN1, PSMA1, SSX2, TBP, TEAD4, TP53BP2, ZNF3, ZNF124, ZRSR2, NAA10, CDC23, AP1M1, TOP3B, LATS1, ZSCAN12, ZBTB24, SSX3, KAT5, WDR5, ABLIM3, TFIP11, PRPF31, POLL, C11orf54, SYT17, FAM64A, CCHCR1, CHCHD3, FANCL, CEP55, C14orf105, C19orf66, CDCA7L, FAM214A, TRIM54, KLHL42, ZNF250, KIF9, CARD9, AEN, TTC23, SCNM1, C20orf195, NOL12, FAM124B, INO80B, FAM161A, ZGPAT, BEX2, ZNF587, FBF1, MRPL53, SSX2IP, MORN4, FRMD6, KRT40, ZNF792, ZNF417, ZMAT2, TRIM42, KRTAP10-7, GOLGA8F, BRCA1, WRAP73, BTRC, MED4, HERC2, CEP128, LCA5, CEP290, CEP162, PCM1, PTCD3, IPO7, CEP131, MIB1, TUBA1A, NAP1L4, TUBB2A, CCDC138, DNAJA3, CCAR1, NTPCR, NUMA1, SCLT1, RCN1, SREK1, AHI1, AKTIP, CAMSAP1, CCDC85C, CCT7, CENPH, CEP350, CEP85, CKAP2, DVL1, DVL2, DVL3, ECH1, FAM120A, FAM21A, FMR1, GPATCH1, HAUS3, HAUS4, HAUS6, HAUS8, HOOK3, IFT74, KANK2, KATNA1, KATNB1, KIAA0753, KIAA1671, LRRC49, LUZP1, NEDD1, OFD1, PIBF1, PLEKHG1, PPP1R13B, RINT1, SDCCAG3, TCHP, TNRC6B, TP53, TPGS1, TRIM26, TTK, TXLNG, WDR83, XRN1, ABLIM1, ADSL, C19orf25, CNOT1, CSPP1, DHX35, EIF4ENIF1, HAUS1, IPO8, IRAK1, KIF7, LIMD1, MAP7D3, NDEL1, NME7, OCRL, PDLIM5, PTAR1, SEC24B, SIPA1L2, SMG7, TAB1, TBK1, TNIP1, TNRC6A, TNRC6C, TRIM9, TRIP6, VCPIP1, TBC1D31, CC2D2A, CEP104, CEP120, SPICE1, CEP135, CEP63, CEP89, CNTRL, NIN, ODF2, RPGRIP1L, POC5, SASS6, STIL, CENPJ, ZFYVE26, ZNF71, NIF3L1, XPO1, XRCC3, DYNLL1, FGFR1OP, MAPRE1, SDHAF2, CCDC14, TGS1, PTPN22, TPTE2, LZTS2, CRNNWDPCPTRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSX2IP_WDPCP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSX2IP_WDPCP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDPCPC1857587Orstavik Lindemann Solberg syndrome1UNIPROT