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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36210

FusionGeneSummary for SSX2IP_LPAR3

check button Fusion gene summary
Fusion gene informationFusion gene name: SSX2IP_LPAR3
Fusion gene ID: 36210
HgeneTgene
Gene symbol

SSX2IP

LPAR3

Gene ID

117178

23566

Gene nameSSX family member 2 interacting proteinlysophosphatidic acid receptor 3
SynonymsADIP|hMsd1EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3
Cytomap

1p22.3

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionafadin- and alpha-actinin-binding proteinSSX2-interacting proteinafadin DIL domain-interacting proteinsynovial sarcoma, X breakpoint 2 interacting proteinlysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysoph
Modification date2018052220180519
UniProtAcc

Q9Y2D8

Q9UBY5

Ensembl transtripts involved in fusion geneENST00000437941, ENST00000342203, 
ENST00000605755, ENST00000603677, 
ENST00000370612, 
ENST00000440886, 
ENST00000370611, ENST00000491034, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SSX2IP [Title/Abstract] AND LPAR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1736-01BSSX2IPchr1

85155837

-LPAR3chr1

85279854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000437941ENST00000440886SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
5UTR-3CDSENST00000437941ENST00000370611SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
5UTR-5UTRENST00000437941ENST00000491034SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000342203ENST00000440886SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000342203ENST00000370611SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-5UTRENST00000342203ENST00000491034SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000605755ENST00000440886SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000605755ENST00000370611SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-5UTRENST00000605755ENST00000491034SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
5UTR-3CDSENST00000603677ENST00000440886SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
5UTR-3CDSENST00000603677ENST00000370611SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
5UTR-5UTRENST00000603677ENST00000491034SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000370612ENST00000440886SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-3CDSENST00000370612ENST00000370611SSX2IPchr1

85155837

-LPAR3chr1

85279854

-
intron-5UTRENST00000370612ENST00000491034SSX2IPchr1

85155837

-LPAR3chr1

85279854

-

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FusionProtFeatures for SSX2IP_LPAR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSX2IP

Q9Y2D8

LPAR3

Q9UBY5

Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSX2IP_LPAR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSX2IP_LPAR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SSX2IPMLLT4, ACTN1, USP11, ELAVL1, CDC42, CCNH, YWHAZ, IKBKG, YWHAQ, LATS2, KDM1A, PRMT6, ARNT2, NDN, CEP250, XIAP, BYSL, DAXX, PHC2, EHHADH, EIF4A2, GEM, KRT15, KRT31, LMO2, MFAP1, MOS, TRIM37, DRG1, PRKAA1, PKN1, PSMA1, SSX2, TBP, TEAD4, TP53BP2, ZNF3, ZNF124, ZRSR2, NAA10, CDC23, AP1M1, TOP3B, LATS1, ZSCAN12, ZBTB24, SSX3, KAT5, WDR5, ABLIM3, TFIP11, PRPF31, POLL, C11orf54, SYT17, FAM64A, CCHCR1, CHCHD3, FANCL, CEP55, C14orf105, C19orf66, CDCA7L, FAM214A, TRIM54, KLHL42, ZNF250, KIF9, CARD9, AEN, TTC23, SCNM1, C20orf195, NOL12, FAM124B, INO80B, FAM161A, ZGPAT, BEX2, ZNF587, FBF1, MRPL53, SSX2IP, MORN4, FRMD6, KRT40, ZNF792, ZNF417, ZMAT2, TRIM42, KRTAP10-7, GOLGA8F, BRCA1, WRAP73, BTRC, MED4, HERC2, CEP128, LCA5, CEP290, CEP162, PCM1, PTCD3, IPO7, CEP131, MIB1, TUBA1A, NAP1L4, TUBB2A, CCDC138, DNAJA3, CCAR1, NTPCR, NUMA1, SCLT1, RCN1, SREK1, AHI1, AKTIP, CAMSAP1, CCDC85C, CCT7, CENPH, CEP350, CEP85, CKAP2, DVL1, DVL2, DVL3, ECH1, FAM120A, FAM21A, FMR1, GPATCH1, HAUS3, HAUS4, HAUS6, HAUS8, HOOK3, IFT74, KANK2, KATNA1, KATNB1, KIAA0753, KIAA1671, LRRC49, LUZP1, NEDD1, OFD1, PIBF1, PLEKHG1, PPP1R13B, RINT1, SDCCAG3, TCHP, TNRC6B, TP53, TPGS1, TRIM26, TTK, TXLNG, WDR83, XRN1, ABLIM1, ADSL, C19orf25, CNOT1, CSPP1, DHX35, EIF4ENIF1, HAUS1, IPO8, IRAK1, KIF7, LIMD1, MAP7D3, NDEL1, NME7, OCRL, PDLIM5, PTAR1, SEC24B, SIPA1L2, SMG7, TAB1, TBK1, TNIP1, TNRC6A, TNRC6C, TRIM9, TRIP6, VCPIP1, TBC1D31, CC2D2A, CEP104, CEP120, SPICE1, CEP135, CEP63, CEP89, CNTRL, NIN, ODF2, RPGRIP1L, POC5, SASS6, STIL, CENPJ, ZFYVE26, ZNF71, NIF3L1, XPO1, XRCC3, DYNLL1, FGFR1OP, MAPRE1, SDHAF2, CCDC14, TGS1, PTPN22, TPTE2, LZTS2, CRNNLPAR3APP, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSX2IP_LPAR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSX2IP_LPAR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource