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Fusion gene ID: 36210 |
FusionGeneSummary for SSX2IP_LPAR3 |
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Fusion gene information | Fusion gene name: SSX2IP_LPAR3 | Fusion gene ID: 36210 | Hgene | Tgene | Gene symbol | SSX2IP | LPAR3 | Gene ID | 117178 | 23566 |
Gene name | SSX family member 2 interacting protein | lysophosphatidic acid receptor 3 | |
Synonyms | ADIP|hMsd1 | EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3 | |
Cytomap | 1p22.3 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | afadin- and alpha-actinin-binding proteinSSX2-interacting proteinafadin DIL domain-interacting proteinsynovial sarcoma, X breakpoint 2 interacting protein | lysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysoph | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9Y2D8 | Q9UBY5 | |
Ensembl transtripts involved in fusion gene | ENST00000437941, ENST00000342203, ENST00000605755, ENST00000603677, ENST00000370612, | ENST00000440886, ENST00000370611, ENST00000491034, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SSX2IP [Title/Abstract] AND LPAR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-1736-01B | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000437941 | ENST00000440886 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
5UTR-3CDS | ENST00000437941 | ENST00000370611 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
5UTR-5UTR | ENST00000437941 | ENST00000491034 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000342203 | ENST00000440886 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000342203 | ENST00000370611 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-5UTR | ENST00000342203 | ENST00000491034 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000605755 | ENST00000440886 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000605755 | ENST00000370611 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-5UTR | ENST00000605755 | ENST00000491034 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
5UTR-3CDS | ENST00000603677 | ENST00000440886 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
5UTR-3CDS | ENST00000603677 | ENST00000370611 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
5UTR-5UTR | ENST00000603677 | ENST00000491034 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000370612 | ENST00000440886 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-3CDS | ENST00000370612 | ENST00000370611 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
intron-5UTR | ENST00000370612 | ENST00000491034 | SSX2IP | chr1 | 85155837 | - | LPAR3 | chr1 | 85279854 | - |
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FusionProtFeatures for SSX2IP_LPAR3 |
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Hgene | Tgene |
SSX2IP | LPAR3 |
Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSX2IP_LPAR3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSX2IP_LPAR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SSX2IP | MLLT4, ACTN1, USP11, ELAVL1, CDC42, CCNH, YWHAZ, IKBKG, YWHAQ, LATS2, KDM1A, PRMT6, ARNT2, NDN, CEP250, XIAP, BYSL, DAXX, PHC2, EHHADH, EIF4A2, GEM, KRT15, KRT31, LMO2, MFAP1, MOS, TRIM37, DRG1, PRKAA1, PKN1, PSMA1, SSX2, TBP, TEAD4, TP53BP2, ZNF3, ZNF124, ZRSR2, NAA10, CDC23, AP1M1, TOP3B, LATS1, ZSCAN12, ZBTB24, SSX3, KAT5, WDR5, ABLIM3, TFIP11, PRPF31, POLL, C11orf54, SYT17, FAM64A, CCHCR1, CHCHD3, FANCL, CEP55, C14orf105, C19orf66, CDCA7L, FAM214A, TRIM54, KLHL42, ZNF250, KIF9, CARD9, AEN, TTC23, SCNM1, C20orf195, NOL12, FAM124B, INO80B, FAM161A, ZGPAT, BEX2, ZNF587, FBF1, MRPL53, SSX2IP, MORN4, FRMD6, KRT40, ZNF792, ZNF417, ZMAT2, TRIM42, KRTAP10-7, GOLGA8F, BRCA1, WRAP73, BTRC, MED4, HERC2, CEP128, LCA5, CEP290, CEP162, PCM1, PTCD3, IPO7, CEP131, MIB1, TUBA1A, NAP1L4, TUBB2A, CCDC138, DNAJA3, CCAR1, NTPCR, NUMA1, SCLT1, RCN1, SREK1, AHI1, AKTIP, CAMSAP1, CCDC85C, CCT7, CENPH, CEP350, CEP85, CKAP2, DVL1, DVL2, DVL3, ECH1, FAM120A, FAM21A, FMR1, GPATCH1, HAUS3, HAUS4, HAUS6, HAUS8, HOOK3, IFT74, KANK2, KATNA1, KATNB1, KIAA0753, KIAA1671, LRRC49, LUZP1, NEDD1, OFD1, PIBF1, PLEKHG1, PPP1R13B, RINT1, SDCCAG3, TCHP, TNRC6B, TP53, TPGS1, TRIM26, TTK, TXLNG, WDR83, XRN1, ABLIM1, ADSL, C19orf25, CNOT1, CSPP1, DHX35, EIF4ENIF1, HAUS1, IPO8, IRAK1, KIF7, LIMD1, MAP7D3, NDEL1, NME7, OCRL, PDLIM5, PTAR1, SEC24B, SIPA1L2, SMG7, TAB1, TBK1, TNIP1, TNRC6A, TNRC6C, TRIM9, TRIP6, VCPIP1, TBC1D31, CC2D2A, CEP104, CEP120, SPICE1, CEP135, CEP63, CEP89, CNTRL, NIN, ODF2, RPGRIP1L, POC5, SASS6, STIL, CENPJ, ZFYVE26, ZNF71, NIF3L1, XPO1, XRCC3, DYNLL1, FGFR1OP, MAPRE1, SDHAF2, CCDC14, TGS1, PTPN22, TPTE2, LZTS2, CRNN | LPAR3 | APP, LMNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSX2IP_LPAR3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSX2IP_LPAR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |