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Fusion gene ID: 36187 |
FusionGeneSummary for SSR2_SUPT16H |
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Fusion gene information | Fusion gene name: SSR2_SUPT16H | Fusion gene ID: 36187 | Hgene | Tgene | Gene symbol | SSR2 | SUPT16H | Gene ID | 6746 | 11198 |
Gene name | signal sequence receptor subunit 2 | SPT16 homolog, facilitates chromatin remodeling subunit | |
Synonyms | HSD25|TLAP|TRAP-BETA|TRAPB | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
Cytomap | 1q22 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P43308 | Q9Y5B9 | |
Ensembl transtripts involved in fusion gene | ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567, | ENST00000216297, ENST00000555943, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 37 X 4 X 15=2220 |
# samples | 5 | 40 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(40/2220*10)=-2.47248777146274 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SSR2 [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8687-01A | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000295702 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
5CDS-intron | ENST00000295702 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000529008 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000529008 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000496742 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000496742 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000480567 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
intron-intron | ENST00000480567 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
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FusionProtFeatures for SSR2_SUPT16H |
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Hgene | Tgene |
SSR2 | SUPT16H |
TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins. | Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). {ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006,ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704,ECO:0000269|PubMed:9836642}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSR2_SUPT16H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSR2_SUPT16H |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SSR2 | SRPR, NXF1, RPN1, ATP1A1, UQCRC2 | SUPT16H | BRCC3, PRKAA1, POLR1A, POLR1E, SSRP1, CHD1L, MCM4, PAF1, PARP1, H2AFX, MKL1, H3F3A, TRIM33, TAL1, CDK9, SUPT16H, MMS22L, TONSL, SMARCAD1, SREK1, SOX2, HDGF, ELAVL1, XRCC5, CUL3, CDK2, CAND1, FYTTD1, CSNK2A1, CSNK2B, SAP18, RTF1, LEO1, TOP1, DHX15, CTR9, IK, PRPF4B, SNRPD2, NCSTN, S100A9, HNRNPM, NHP2L1, DDX21, PRPF6, SF3A1, SNRPD1, PRPF3, ACIN1, EEF1A1, RBM25, MSH6, PRPF8, USP39, MSH2, PSIP1, CENPA, ESR1, FMNL1, VCP, PNKP, CD81, IGSF8, ICAM1, SRPK2, FTH1, QRICH1, RNF20, ATRX, HIST1H2AB, MOV10, NXF1, BRCA1, CUL7, OBSL1, EED, RNF2, BMI1, SUMO2, ABCE1, RPA4, SPIN2B, RPA2, SPIN1, TIPIN, RNF146, POLB, APLF, HIST1H2BA, MAFF, FBXW11, BRD3, CDK12, HMGB1, IWS1, NAP1L1, PES1, SRRM1, CDK11A, HMGB2, HMGB3, KRI1, TOP2B, ZC3H18, SFN, NTRK1, IFI16, MED4, EWSR1, CEP97, CNTROB, SPICE1, CEP164, DCTN1, POC1B, STIL, HIST1H3E, DAXX, HNRNPU, NPM1, RPL10, ETAA1, CENPQ, NF2, NANOG, UBR5, SBF1, HIST1H3A, MACROD1, H2AFY2, XPC, XRCC6, HIST1H4A, NAA40, WDR76, ALX3, TEAD2, L3MBTL1, CETN1, SIX2, POLL, RPA3, WRN, COX15, DLD, PDHA1, VDAC1, TRIM25, YAP1, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSR2_SUPT16H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSR2_SUPT16H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SSR2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |