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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36185

FusionGeneSummary for SSR2_ACOT11

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR2_ACOT11
Fusion gene ID: 36185
HgeneTgene
Gene symbol

SSR2

ACOT11

Gene ID

6746

26027

Gene namesignal sequence receptor subunit 2acyl-CoA thioesterase 11
SynonymsHSD25|TLAP|TRAP-BETA|TRAPBBFIT|STARD14|THEA|THEM1
Cytomap

1q22

1p32.3

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein betaacyl-coenzyme A thioesterase 11START domain containing 14StAR-related lipid transfer (START) domain containing 14acyl-CoA thioester hydrolase 11adipose-associated thioesterasebrown fat-inducible thioesterasethioesterase superfamily member 1thioeste
Modification date2018052320180523
UniProtAcc

P43308

Q8WXI4

Ensembl transtripts involved in fusion geneENST00000295702, ENST00000529008, 
ENST00000496742, ENST00000480567, 
ENST00000481208, ENST00000343744, 
ENST00000371316, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 2=18
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SSR2 [Title/Abstract] AND ACOT11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A07O-01ASSR2chr1

155987923

-ACOT11chr1

55073615

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000295702ENST00000481208SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000295702ENST00000343744SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000295702ENST00000371316SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000529008ENST00000481208SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000529008ENST00000343744SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000529008ENST00000371316SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000496742ENST00000481208SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000496742ENST00000343744SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000496742ENST00000371316SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000480567ENST00000481208SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000480567ENST00000343744SSR2chr1

155987923

-ACOT11chr1

55073615

+
intron-3UTRENST00000480567ENST00000371316SSR2chr1

155987923

-ACOT11chr1

55073615

+

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FusionProtFeatures for SSR2_ACOT11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSR2

P43308

ACOT11

Q8WXI4

TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins. Has acyl-CoA thioesterase activity towards medium (C12)and long-chain (C18) fatty acyl-CoA substrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSR2_ACOT11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR2_ACOT11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SSR2SRPR, NXF1, RPN1, ATP1A1, UQCRC2ACOT11ACOT11, THUMPD3, TEKT2, ACOT12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSR2_ACOT11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSR2_ACOT11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSSR2C0033578Prostatic Neoplasms1CTD_human