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Fusion gene ID: 36185 |
FusionGeneSummary for SSR2_ACOT11 |
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Fusion gene information | Fusion gene name: SSR2_ACOT11 | Fusion gene ID: 36185 | Hgene | Tgene | Gene symbol | SSR2 | ACOT11 | Gene ID | 6746 | 26027 |
Gene name | signal sequence receptor subunit 2 | acyl-CoA thioesterase 11 | |
Synonyms | HSD25|TLAP|TRAP-BETA|TRAPB | BFIT|STARD14|THEA|THEM1 | |
Cytomap | 1q22 | 1p32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta | acyl-coenzyme A thioesterase 11START domain containing 14StAR-related lipid transfer (START) domain containing 14acyl-CoA thioester hydrolase 11adipose-associated thioesterasebrown fat-inducible thioesterasethioesterase superfamily member 1thioeste | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P43308 | Q8WXI4 | |
Ensembl transtripts involved in fusion gene | ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567, | ENST00000481208, ENST00000343744, ENST00000371316, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 2=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SSR2 [Title/Abstract] AND ACOT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A07O-01A | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000295702 | ENST00000481208 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000295702 | ENST00000343744 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000295702 | ENST00000371316 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000529008 | ENST00000481208 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000529008 | ENST00000343744 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000529008 | ENST00000371316 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000496742 | ENST00000481208 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000496742 | ENST00000343744 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000496742 | ENST00000371316 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000480567 | ENST00000481208 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000480567 | ENST00000343744 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
intron-3UTR | ENST00000480567 | ENST00000371316 | SSR2 | chr1 | 155987923 | - | ACOT11 | chr1 | 55073615 | + |
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FusionProtFeatures for SSR2_ACOT11 |
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Hgene | Tgene |
SSR2 | ACOT11 |
TRAP proteins are part of a complex whose function is tobind calcium to the ER membrane and thereby regulate the retentionof ER resident proteins. | Has acyl-CoA thioesterase activity towards medium (C12)and long-chain (C18) fatty acyl-CoA substrates. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SSR2_ACOT11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SSR2_ACOT11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SSR2 | SRPR, NXF1, RPN1, ATP1A1, UQCRC2 | ACOT11 | ACOT11, THUMPD3, TEKT2, ACOT12 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SSR2_ACOT11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SSR2_ACOT11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SSR2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |